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ASSOCIATION BETWEEN FATIGUE AND EXERCISE CAPACITY IN PATIENTS WITH CHRONIC LIVER DISEASE AWAITING LIVER TRANSPLANTATION.
Arq Gastroenterol 2019; 56(3):252-255AG

Abstract

BACKGROUND

Fatigue is highly prevalent in end stage liver disease, the studies about its association with exercise capacity in cirrhotic patients before liver are scarse.

OBJECTIVE

In this study, we evaluated fatigue in 95 in end stage liver disease patients awaiting transplantation, compared to healthy volunteers, and tested the association between exercise capacity and fatigue.

METHODS

Cross-sectional study of patients with chronic liver disease treated at a referral center in Fortaleza, Brazil. Fatigue was quantified with the Fatigue Severity Scale. The patients were submitted to the 6-min walk test, the 6-min step test, the Hospital Anxiety and Depression Scale, C-reative protein measurement and hematocrit count, measurement of dyspnea among other tests. Fatigue data were obtained from healthy individuals for comparison with patients.

RESULTS

The mean age of patients was 45.9±12.3 years, and 53.7% were male. Fatigue, anxiety and depression levels were higher among end stage liver disease patients than among controls. A negative correlation was observed between 6 min step test and Fatigue Severity Scale score (r= -0.2; P=0.02) and between hematocrit count and Fatigue Severity Scale score (r= -0.24; P=0.002). Dyspnea on the Borg scale and fatigue were positively correlated (r=31; P=0.002). In the multivariate analysis, low 6-min step test values and high levels of dyspnea were associated with fatigue.

CONCLUSION

Fatigue was more prevalent and severe in end stage liver disease patients than in healthy controls. Low 6MST values and high levels of dyspnea were associated with fatigue in this scenario.

Authors+Show Affiliations

Universidade Federal do Ceará, Departamento de Cirurgia, Fortaleza, CE, Brasil.Universidade Federal do Ceará, Departamento de Medicina, Fortaleza, CE, Brasil.Universidade Federal do Ceará, Departamento de Cirurgia, Fortaleza, CE, Brasil. Universidade Federal do Ceará, Hospital Universitário Walter Cantídio (HUWC), Centro de Transplante de Fígado, CE, Brasil.Universidade Federal do Ceará, Hospital Universitário Walter Cantídio (HUWC), Centro de Transplante de Fígado, CE, Brasil.Universidade Federal do Ceará, Hospital Universitário Walter Cantídio (HUWC), Centro de Transplante de Fígado, CE, Brasil.Universidade Federal do Ceará, Departamento de Medicina, Fortaleza, CE, Brasil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31633720

Citation

Lima, Yolanda de B., et al. "ASSOCIATION BETWEEN FATIGUE and EXERCISE CAPACITY in PATIENTS WITH CHRONIC LIVER DISEASE AWAITING LIVER TRANSPLANTATION." Arquivos De Gastroenterologia, vol. 56, no. 3, 2019, pp. 252-255.
Lima YB, Magalhães CBA, Garcia JHP, et al. ASSOCIATION BETWEEN FATIGUE AND EXERCISE CAPACITY IN PATIENTS WITH CHRONIC LIVER DISEASE AWAITING LIVER TRANSPLANTATION. Arq Gastroenterol. 2019;56(3):252-255.
Lima, Y. B., Magalhães, C. B. A., Garcia, J. H. P., Viana, C. F. G., Prudente, G. F. G., & Pereira, E. D. B. (2019). ASSOCIATION BETWEEN FATIGUE AND EXERCISE CAPACITY IN PATIENTS WITH CHRONIC LIVER DISEASE AWAITING LIVER TRANSPLANTATION. Arquivos De Gastroenterologia, 56(3), pp. 252-255. doi:10.1590/S0004-2803.201900000-47.
Lima YB, et al. ASSOCIATION BETWEEN FATIGUE and EXERCISE CAPACITY in PATIENTS WITH CHRONIC LIVER DISEASE AWAITING LIVER TRANSPLANTATION. Arq Gastroenterol. 2019;56(3):252-255. PubMed PMID: 31633720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ASSOCIATION BETWEEN FATIGUE AND EXERCISE CAPACITY IN PATIENTS WITH CHRONIC LIVER DISEASE AWAITING LIVER TRANSPLANTATION. AU - Lima,Yolanda de B, AU - Magalhães,Clarissa B A, AU - Garcia,José Huygens P, AU - Viana,Cyntia F G, AU - Prudente,Geisyani Francisca G, AU - Pereira,Eanes D B, Y1 - 2019/09/30/ PY - 2019/01/16/received PY - 2019/07/17/accepted PY - 2019/10/22/entrez PY - 2019/10/22/pubmed PY - 2019/10/22/medline SP - 252 EP - 255 JF - Arquivos de gastroenterologia JO - Arq Gastroenterol VL - 56 IS - 3 N2 - BACKGROUND: Fatigue is highly prevalent in end stage liver disease, the studies about its association with exercise capacity in cirrhotic patients before liver are scarse. OBJECTIVE: In this study, we evaluated fatigue in 95 in end stage liver disease patients awaiting transplantation, compared to healthy volunteers, and tested the association between exercise capacity and fatigue. METHODS: Cross-sectional study of patients with chronic liver disease treated at a referral center in Fortaleza, Brazil. Fatigue was quantified with the Fatigue Severity Scale. The patients were submitted to the 6-min walk test, the 6-min step test, the Hospital Anxiety and Depression Scale, C-reative protein measurement and hematocrit count, measurement of dyspnea among other tests. Fatigue data were obtained from healthy individuals for comparison with patients. RESULTS: The mean age of patients was 45.9±12.3 years, and 53.7% were male. Fatigue, anxiety and depression levels were higher among end stage liver disease patients than among controls. A negative correlation was observed between 6 min step test and Fatigue Severity Scale score (r= -0.2; P=0.02) and between hematocrit count and Fatigue Severity Scale score (r= -0.24; P=0.002). Dyspnea on the Borg scale and fatigue were positively correlated (r=31; P=0.002). In the multivariate analysis, low 6-min step test values and high levels of dyspnea were associated with fatigue. CONCLUSION: Fatigue was more prevalent and severe in end stage liver disease patients than in healthy controls. Low 6MST values and high levels of dyspnea were associated with fatigue in this scenario. SN - 1678-4219 UR - https://www.unboundmedicine.com/medline/citation/31633720/ASSOCIATION_BETWEEN_FATIGUE_AND_EXERCISE_CAPACITY_IN_PATIENTS_WITH_CHRONIC_LIVER_DISEASE_AWAITING_LIVER_TRANSPLANTATION L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032019000300252&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -