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The relationship between resting electroencephalogram oscillatory abnormalities and schizotypal personality traits in the first-degree relatives of schizophrenia patients.
Neuroreport 2019; 30(17):1215-1221N

Abstract

Although a large amount of studies have manifested resting state electroencephalogram oscillatory abnormalities in schizophrenia and their first-degree relatives and in schizotype, the results are far from consistent and no research found any relationship between electroencephalograph (EEG) abnormalities and schizotypal personality in first-degree relatives. The present study is to verify the modifications of EEG power spectra in eyes-open resting state of schizophrenia and first-degree relatives, and to investigate associations between EEG band power and schizotypal personality traits in first-degree relatives of schizophrenia patients. Participant samples in this study consisted of 33 healthy normal controls, 35 unaffected first-degree relatives of schizophrenia patients and 35 schizophrenia patients. Group differences in resting EEG band power were examined via repeated-measures analysis of variance, and correlation between EEG power and schizotypal personality traits via Pearson Correlation analysis. The results showed that patients with schizophrenia exhibited increased delta, theta and alpha activity over anterior and central regions in eyes-open resting state compared with that of normal control. Gamma band power was found for the first time to be negatively correlated to schizotypal personality traits in first-degree relatives of schizophrenia patients. To conclusion, these findings suggested that low-frequency EEG activity might be neural manifestations of pathophysiological changes in the brain of schizophrenia, and gamma band activity might be an approach to measure the genetic liability of the disorder.

Authors+Show Affiliations

Department of Military Medical Psychology, Fourth Military Medical University (Air Force Medical University), Xi'an.Department of Military Medical Psychology, Fourth Military Medical University (Air Force Medical University), Xi'an.Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, No. 988 Hospital of Joint Logistic Support Force of PLA, Jiaozuo.The Fourth Department of Psychiatry, No. 984 Hospital of Joint Logistic Support Force of PLA, Beijing.Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, No. 988 Hospital of Joint Logistic Support Force of PLA, Jiaozuo.Department of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, No. 987 Hospital of Joint Logistic Support Force of PLA, Baoji.No affiliation info availableYouth and Children's Psychological Center, No. 904 Hospital of Joint Logistic Support Force of PLA, Changzhou.Department of Military Medical Psychology, Fourth Military Medical University (Air Force Medical University), Xi'an.Department of Mental Health, Xi'an Medical University, Xi'an, China.Department of Military Medical Psychology, Fourth Military Medical University (Air Force Medical University), Xi'an.Department of Military Medical Psychology, Fourth Military Medical University (Air Force Medical University), Xi'an.Department of Military Medical Psychology, Fourth Military Medical University (Air Force Medical University), Xi'an.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31634240

Citation

Chen, Chen, et al. "The Relationship Between Resting Electroencephalogram Oscillatory Abnormalities and Schizotypal Personality Traits in the First-degree Relatives of Schizophrenia Patients." Neuroreport, vol. 30, no. 17, 2019, pp. 1215-1221.
Chen C, Huang W, Chen X, et al. The relationship between resting electroencephalogram oscillatory abnormalities and schizotypal personality traits in the first-degree relatives of schizophrenia patients. Neuroreport. 2019;30(17):1215-1221.
Chen, C., Huang, W., Chen, X., Shi, X., Zhu, X., Ma, W., ... Liu, X. (2019). The relationship between resting electroencephalogram oscillatory abnormalities and schizotypal personality traits in the first-degree relatives of schizophrenia patients. Neuroreport, 30(17), pp. 1215-1221. doi:10.1097/WNR.0000000000001350.
Chen C, et al. The Relationship Between Resting Electroencephalogram Oscillatory Abnormalities and Schizotypal Personality Traits in the First-degree Relatives of Schizophrenia Patients. Neuroreport. 2019 Dec 10;30(17):1215-1221. PubMed PMID: 31634240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between resting electroencephalogram oscillatory abnormalities and schizotypal personality traits in the first-degree relatives of schizophrenia patients. AU - Chen,Chen, AU - Huang,Wei, AU - Chen,Xianjun, AU - Shi,Xiufang, AU - Zhu,Xiquan, AU - Ma,Wentao, AU - Wang,Yapei, AU - Kang,Qi, AU - Wang,Xiuchao, AU - Guan,Muzhen, AU - Huang,He, AU - Wu,Shengjun, AU - Liu,Xufeng, PY - 2019/10/22/pubmed PY - 2019/10/22/medline PY - 2019/10/22/entrez SP - 1215 EP - 1221 JF - Neuroreport JO - Neuroreport VL - 30 IS - 17 N2 - Although a large amount of studies have manifested resting state electroencephalogram oscillatory abnormalities in schizophrenia and their first-degree relatives and in schizotype, the results are far from consistent and no research found any relationship between electroencephalograph (EEG) abnormalities and schizotypal personality in first-degree relatives. The present study is to verify the modifications of EEG power spectra in eyes-open resting state of schizophrenia and first-degree relatives, and to investigate associations between EEG band power and schizotypal personality traits in first-degree relatives of schizophrenia patients. Participant samples in this study consisted of 33 healthy normal controls, 35 unaffected first-degree relatives of schizophrenia patients and 35 schizophrenia patients. Group differences in resting EEG band power were examined via repeated-measures analysis of variance, and correlation between EEG power and schizotypal personality traits via Pearson Correlation analysis. The results showed that patients with schizophrenia exhibited increased delta, theta and alpha activity over anterior and central regions in eyes-open resting state compared with that of normal control. Gamma band power was found for the first time to be negatively correlated to schizotypal personality traits in first-degree relatives of schizophrenia patients. To conclusion, these findings suggested that low-frequency EEG activity might be neural manifestations of pathophysiological changes in the brain of schizophrenia, and gamma band activity might be an approach to measure the genetic liability of the disorder. SN - 1473-558X UR - https://www.unboundmedicine.com/medline/citation/31634240/The_relationship_between_resting_electroencephalogram_oscillatory_abnormalities_and_schizotypal_personality_traits_in_the_first-degree_relatives_of_schizophrenia_patients L2 - http://dx.doi.org/10.1097/WNR.0000000000001350 DB - PRIME DP - Unbound Medicine ER -