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Regulatory cytokines prescribe the outcome of the inflammation in the process of PEX production.

Abstract

BACKGROUND

The purpose of this study is to reveal the participation of different regulatory cytokines within the process of pseudoexfoliation (PEX).

METHODS

Our study included 140 patients referred to cataract surgery with early and late stage of pseudoexfoliation syndrome (XFS) or pseudoexfoliation glaucoma (XFG). Humor and serum levels of cytokines TGF-β, PDGF, EGF, IGF, IL-8 and ITAC were measured in a sample using high sensitivity enzyme-linked immunoabsorbent assay (ELISA) kit.

RESULTS

Our results indicate that profibrotic action induced by increasing TGF-β and PDGF locally activates fibrous tissue production in the early XFS with a prolonged effect of PDGF (late XFS) and finally (XFG stage) it is dominantly controlled by EGF and IGF. ITAC overrides angiogenetic effects of IL-8 in XFG.

CONCLUSION

Based on our findings local chronic inflammation in the eye is accompanied by the secretion of different profibrotic cytokines (TGF-β, PDGF, EGF, IGF, IL-8) without angiogenesis due to effects of ITAC.

Authors+Show Affiliations

Department of Ophthalmology, Faculty of Medical Sciences, Clinical Center Kragujevac, University of Kragujevac, Serbia.Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, Serbia.University Union- Nikola Tesla, Belgrade, Serbia and The Balkans Scientific Center of the Russian Academy of Natural Sciences, Belgrade, Serbia.Department of Internal medicine, Faculty of Medical Sciences, Clinical Center Kragujevac, University of Kragujevac, Serbia.Department of Ophthalmology, Faculty of Medical Sciences, Clinical Center Kragujevac, University of Kragujevac, Serbia.Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Serbia and The Balkans Scientific Center of the Russian Academy of Natural Sciences, Belgrade, Serbia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31634339

Citation

Sarenac Vulovic, Tatjana, et al. "Regulatory Cytokines Prescribe the Outcome of the Inflammation in the Process of PEX Production." Journal of the Chinese Medical Association : JCMA, 2019.
Sarenac Vulovic T, Pavlovic S, Lutovac M, et al. Regulatory cytokines prescribe the outcome of the inflammation in the process of PEX production. J Chin Med Assoc. 2019.
Sarenac Vulovic, T., Pavlovic, S., Lutovac, M., Zdravkovic, V., Sreckovic, S., & Zdravkovic, N. (2019). Regulatory cytokines prescribe the outcome of the inflammation in the process of PEX production. Journal of the Chinese Medical Association : JCMA, doi:10.1097/JCMA.0000000000000214.
Sarenac Vulovic T, et al. Regulatory Cytokines Prescribe the Outcome of the Inflammation in the Process of PEX Production. J Chin Med Assoc. 2019 Oct 14; PubMed PMID: 31634339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulatory cytokines prescribe the outcome of the inflammation in the process of PEX production. AU - Sarenac Vulovic,Tatjana, AU - Pavlovic,Sladjana, AU - Lutovac,Mitar, AU - Zdravkovic,Vladimir, AU - Sreckovic,Suncica, AU - Zdravkovic,Nemanja, Y1 - 2019/10/14/ PY - 2019/10/22/entrez PY - 2019/10/22/pubmed PY - 2019/10/22/medline JF - Journal of the Chinese Medical Association : JCMA JO - J Chin Med Assoc N2 - BACKGROUND: The purpose of this study is to reveal the participation of different regulatory cytokines within the process of pseudoexfoliation (PEX). METHODS: Our study included 140 patients referred to cataract surgery with early and late stage of pseudoexfoliation syndrome (XFS) or pseudoexfoliation glaucoma (XFG). Humor and serum levels of cytokines TGF-β, PDGF, EGF, IGF, IL-8 and ITAC were measured in a sample using high sensitivity enzyme-linked immunoabsorbent assay (ELISA) kit. RESULTS: Our results indicate that profibrotic action induced by increasing TGF-β and PDGF locally activates fibrous tissue production in the early XFS with a prolonged effect of PDGF (late XFS) and finally (XFG stage) it is dominantly controlled by EGF and IGF. ITAC overrides angiogenetic effects of IL-8 in XFG. CONCLUSION: Based on our findings local chronic inflammation in the eye is accompanied by the secretion of different profibrotic cytokines (TGF-β, PDGF, EGF, IGF, IL-8) without angiogenesis due to effects of ITAC. SN - 1728-7731 UR - https://www.unboundmedicine.com/medline/citation/31634339/Regulatory_cytokines_prescribe_the_outcome_of_the_inflammation_in_the_process_of_PEX_production L2 - http://dx.doi.org/10.1097/JCMA.0000000000000214 DB - PRIME DP - Unbound Medicine ER -