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Serum endocan and preoperative systemic inflammatory markers in patients with epilepsy.

Abstract

OBJECTIVE

The mechanisms underlying epileptogenesis are still a focus of experimental and clinical research. Inflammation and angiogenesis are the two main topics that have been an area of interest recently. The present study assessed serum levels of endocan, an inflammatory and angiogenesis-promoting molecule, and of preoperative inflammatory markers (neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR)) in adult patients undergoing epilepsy surgery.

METHODS

Twenty-one patients with epilepsy and 21 healthy controls were included. From patients, serum was collected twice: before and within a week after surgery. From controls, serum was collected once. Serum endocan was studied by ELISA and preoperative NLR and PLR were obtained from preoperative hemogram parameters.

RESULTS

Preoperative serum endocan levels in patients were significantly higher than in controls. There was no difference between patients and controls regarding preoperative NLR and PLR. After surgery, serum endocan levels decreased in patients, with no further difference compared to controls. Serum endocan levels, NLR and PLR correlated positively, but not significantly, with epilepsy duration and seizure frequency.

CONCLUSIONS

Angiogenesis and low-grade inflammation may play a role in the development and progression of epilepsy. We suggest that larger cohort of epilepsy patients with longer-term follow-up should be studied.

Authors+Show Affiliations

Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: dr.ahmetfarukozdemir@gmail.com.Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: rakemerdere@yahoo.com.Clinical Biochemistry Laboratory, Istanbul Training and Research Hospital, Istanbul, Turkey. Electronic address: bagnuorhan@gmail.com.Clinical Biochemistry Laboratory, Istanbul Training and Research Hospital, Istanbul, Turkey. Electronic address: hmyozemre@gmail.com.Clinical Biochemistry Laboratory, Istanbul Training and Research Hospital, Istanbul, Turkey. Electronic address: drberrininal@gmail.com.Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: kayhanmd@gmail.com.Department of Neurology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: snaz@istanbul.edu.tr.Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address: tanerato2000@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31634507

Citation

Faruk Ozdemir, A, et al. "Serum Endocan and Preoperative Systemic Inflammatory Markers in Patients With Epilepsy." Neuro-Chirurgie, 2019.
Faruk Ozdemir A, Kemerdere R, Orhan B, et al. Serum endocan and preoperative systemic inflammatory markers in patients with epilepsy. Neurochirurgie. 2019.
Faruk Ozdemir, A., Kemerdere, R., Orhan, B., Ozturk Emre, H., Bercik Inal, B., Kayhan, A., ... Tanriverdi, T. (2019). Serum endocan and preoperative systemic inflammatory markers in patients with epilepsy. Neuro-Chirurgie, doi:10.1016/j.neuchi.2019.09.025.
Faruk Ozdemir A, et al. Serum Endocan and Preoperative Systemic Inflammatory Markers in Patients With Epilepsy. Neurochirurgie. 2019 Oct 18; PubMed PMID: 31634507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum endocan and preoperative systemic inflammatory markers in patients with epilepsy. AU - Faruk Ozdemir,A, AU - Kemerdere,R, AU - Orhan,B, AU - Ozturk Emre,H, AU - Bercik Inal,B, AU - Kayhan,A, AU - Naz Yeni,S, AU - Tanriverdi,T, Y1 - 2019/10/18/ PY - 2019/04/17/received PY - 2019/08/02/revised PY - 2019/09/10/accepted PY - 2019/10/22/pubmed PY - 2019/10/22/medline PY - 2019/10/22/entrez KW - Angiogenesis KW - Endocan KW - Epilepsy KW - Inflammation KW - Preoperative inflammatory marker JF - Neuro-Chirurgie JO - Neurochirurgie N2 - OBJECTIVE: The mechanisms underlying epileptogenesis are still a focus of experimental and clinical research. Inflammation and angiogenesis are the two main topics that have been an area of interest recently. The present study assessed serum levels of endocan, an inflammatory and angiogenesis-promoting molecule, and of preoperative inflammatory markers (neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR)) in adult patients undergoing epilepsy surgery. METHODS: Twenty-one patients with epilepsy and 21 healthy controls were included. From patients, serum was collected twice: before and within a week after surgery. From controls, serum was collected once. Serum endocan was studied by ELISA and preoperative NLR and PLR were obtained from preoperative hemogram parameters. RESULTS: Preoperative serum endocan levels in patients were significantly higher than in controls. There was no difference between patients and controls regarding preoperative NLR and PLR. After surgery, serum endocan levels decreased in patients, with no further difference compared to controls. Serum endocan levels, NLR and PLR correlated positively, but not significantly, with epilepsy duration and seizure frequency. CONCLUSIONS: Angiogenesis and low-grade inflammation may play a role in the development and progression of epilepsy. We suggest that larger cohort of epilepsy patients with longer-term follow-up should be studied. SN - 1773-0619 UR - https://www.unboundmedicine.com/medline/citation/31634507/Serum_Endocan_and_Preoperative_Systemic_Inflammatory_Markers_in_Patients_with_Epilepsy L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3770(19)30240-1 DB - PRIME DP - Unbound Medicine ER -