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Antimicrobial susceptibility profiles of anaerobic bacteria, isolated from human clinical specimens, within different European and surrounding countries. A joint ESGAI study.
Anaerobe 2019; 61:102111A

Abstract

OBJECTIVES

Studies on the antimicrobial susceptibility profile of anaerobic bacteria are underrepresented in the literature. Within this study we aim to give an extensive overview of the differences in antimicrobial susceptibility profiles between different European and surrounding countries.

METHODS

Minimal inhibitory concentration (MIC) data of different antibiotics were collected from 10 participating laboratories, representing an equal number of countries. All MIC's were determined using Etest, according to the protocol used by the participating laboratory. Anaerobic genera represented by at least 10 clinical isolates were included in the study.

RESULTS

Each country tested different antibiotics, sometimes depending on the kind of infection and/or the anaerobic species isolated. All countries tested clindamycin and metronidazole. Resistance rates differed remarkably between the different countries. Especially in Kuwait, resistance was high for all tested antibiotics. Unexpected metronidazole resistance was observed for Finegoldia magna isolates, Peptoniphilus isolates and Eggerthella lenta isolates.

CONCLUSIONS

Due to the extensive differences in antimicrobial susceptibility profile of anaerobic bacteria isolated within different countries, we strongly recommend to perform this kind of study on a regular basis.

Authors+Show Affiliations

University of Groningen, University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, the Netherlands. Electronic address: a.c.m.veloo@umcg.nl.Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of Medical Microbiology, Istanbul, Turkey.Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France; MIVEGEC, IRD, CNRS, Université de Montpellier, Montpellier, France.Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France; MIVEGEC, IRD, CNRS, Université de Montpellier, Montpellier, France.Institute for Microbiology and Immunology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.Analyses et Diagnostics Médicaux (ADMed) Microbiologie, La Chaux-de-Fonds, Switzerland.University Hospital Center of Split, University of Split, School of Medicine, Split, Croatia.Institute for Medical Microbiology and Epidemiology of Infectious Diseases, Leipzig University Hospital, Leipzig, Germany.Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.Department of Microbiology and Infection Control, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium.Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31634565

Citation

Veloo, A C M., et al. "Antimicrobial Susceptibility Profiles of Anaerobic Bacteria, Isolated From Human Clinical Specimens, Within Different European and Surrounding Countries. a Joint ESGAI Study." Anaerobe, vol. 61, 2019, p. 102111.
Veloo ACM, Tokman HB, Jean-Pierre H, et al. Antimicrobial susceptibility profiles of anaerobic bacteria, isolated from human clinical specimens, within different European and surrounding countries. A joint ESGAI study. Anaerobe. 2019;61:102111.
Veloo, A. C. M., Tokman, H. B., Jean-Pierre, H., Dumont, Y., Jeverica, S., Lienhard, R., ... Nagy, E. (2019). Antimicrobial susceptibility profiles of anaerobic bacteria, isolated from human clinical specimens, within different European and surrounding countries. A joint ESGAI study. Anaerobe, 61, p. 102111. doi:10.1016/j.anaerobe.2019.102111.
Veloo ACM, et al. Antimicrobial Susceptibility Profiles of Anaerobic Bacteria, Isolated From Human Clinical Specimens, Within Different European and Surrounding Countries. a Joint ESGAI Study. Anaerobe. 2019 Oct 18;61:102111. PubMed PMID: 31634565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial susceptibility profiles of anaerobic bacteria, isolated from human clinical specimens, within different European and surrounding countries. A joint ESGAI study. AU - Veloo,A C M, AU - Tokman,H Bahar, AU - Jean-Pierre,H, AU - Dumont,Y, AU - Jeverica,S, AU - Lienhard,R, AU - Novak,A, AU - Rodloff,A, AU - Rotimi,V, AU - Wybo,I, AU - Nagy,E, AU - ,, Y1 - 2019/10/18/ PY - 2019/09/17/received PY - 2019/10/14/revised PY - 2019/10/15/accepted PY - 2019/10/22/pubmed PY - 2019/10/22/medline PY - 2019/10/22/entrez KW - Anaerobic bacteria KW - Antibiotics KW - ESGAI study KW - Europe KW - Resistance profile SP - 102111 EP - 102111 JF - Anaerobe JO - Anaerobe VL - 61 N2 - OBJECTIVES: Studies on the antimicrobial susceptibility profile of anaerobic bacteria are underrepresented in the literature. Within this study we aim to give an extensive overview of the differences in antimicrobial susceptibility profiles between different European and surrounding countries. METHODS: Minimal inhibitory concentration (MIC) data of different antibiotics were collected from 10 participating laboratories, representing an equal number of countries. All MIC's were determined using Etest, according to the protocol used by the participating laboratory. Anaerobic genera represented by at least 10 clinical isolates were included in the study. RESULTS: Each country tested different antibiotics, sometimes depending on the kind of infection and/or the anaerobic species isolated. All countries tested clindamycin and metronidazole. Resistance rates differed remarkably between the different countries. Especially in Kuwait, resistance was high for all tested antibiotics. Unexpected metronidazole resistance was observed for Finegoldia magna isolates, Peptoniphilus isolates and Eggerthella lenta isolates. CONCLUSIONS: Due to the extensive differences in antimicrobial susceptibility profile of anaerobic bacteria isolated within different countries, we strongly recommend to perform this kind of study on a regular basis. SN - 1095-8274 UR - https://www.unboundmedicine.com/medline/citation/31634565/Antimicrobial_susceptibility_profiles_of_anaerobic_bacteria,_isolated_from_human_clinical_specimens,_within_different_European_and_surrounding_countries._A_joint_ESGAI_study L2 - https://linkinghub.elsevier.com/retrieve/pii/S1075-9964(19)30183-0 DB - PRIME DP - Unbound Medicine ER -