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Further galphimines from a new population of Galphimia glauca.
Phytochemistry 2019; 169:112180P

Abstract

Both DNA barcoding and phylogenetic data of the studied botanical material suggested the existence a new population of Galphimia glauca. Their leaves afforded three new nor-3,4-seco-friedelanes named galphimines M-O, together with known galphimines D, E, G, and I. Galphimines M and N possess bicyclic orthoacetates which are the first examples of orthoesters found in the Malpighiaceae family, while galphimine O has a 27,20-δ-lactone moiety. The structures elucidation followed from spectroscopic means and the absolute configuration followed from single crystal X-ray diffraction analyses. Tests for antibacterial and antifungal activities of galphimines N and M showed no promising effects.

Authors+Show Affiliations

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Mexico City, 04510, Mexico.CONACYT-Consorcio de Investigación Innovación y Desarrollo para las Zonas Áridas, Instituto Potosino de Investigación Científica y Tecnológica A. C., Camino a la Presa San José 2055, San Luis Potosí, 78216, Mexico.Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apartado 14-740, Mexico City, 07000, Mexico.CONACYT-Consorcio de Investigación Innovación y Desarrollo para las Zonas Áridas, Instituto Potosino de Investigación Científica y Tecnológica A. C., Camino a la Presa San José 2055, San Luis Potosí, 78216, Mexico.Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Mexico City, 04510, Mexico.Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apartado 14-740, Mexico City, 07000, Mexico.CONACYT-Consorcio de Investigación Innovación y Desarrollo para las Zonas Áridas, Instituto Potosino de Investigación Científica y Tecnológica A. C., Camino a la Presa San José 2055, San Luis Potosí, 78216, Mexico.CONACYT-Consorcio de Investigación Innovación y Desarrollo para las Zonas Áridas, Instituto Potosino de Investigación Científica y Tecnológica A. C., Camino a la Presa San José 2055, San Luis Potosí, 78216, Mexico. Electronic address: francisco.bautista@ipicyt.edu.mx.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31634725

Citation

Ortega, Alfredo, et al. "Further Galphimines From a New Population of Galphimia Glauca." Phytochemistry, vol. 169, 2019, p. 112180.
Ortega A, Pastor-Palacios G, Ortiz-Pastrana N, et al. Further galphimines from a new population of Galphimia glauca. Phytochemistry. 2019;169:112180.
Ortega, A., Pastor-Palacios, G., Ortiz-Pastrana, N., Ávila-Cabezas, E., Toscano, R. A., Joseph-Nathan, P., ... Bautista, E. (2019). Further galphimines from a new population of Galphimia glauca. Phytochemistry, 169, p. 112180. doi:10.1016/j.phytochem.2019.112180.
Ortega A, et al. Further Galphimines From a New Population of Galphimia Glauca. Phytochemistry. 2019 Oct 18;169:112180. PubMed PMID: 31634725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further galphimines from a new population of Galphimia glauca. AU - Ortega,Alfredo, AU - Pastor-Palacios,Guillermo, AU - Ortiz-Pastrana,Naytzé, AU - Ávila-Cabezas,Emmanuel, AU - Toscano,Rubén A, AU - Joseph-Nathan,Pedro, AU - Morales-Jiménez,Jesús, AU - Bautista,Elihú, Y1 - 2019/10/18/ PY - 2019/05/08/received PY - 2019/10/07/revised PY - 2019/10/12/accepted PY - 2019/10/22/pubmed PY - 2019/10/22/medline PY - 2019/10/22/entrez KW - Absolute configuration KW - Bicyclic orthoesters KW - DNA barcoding KW - Galphimia glauca KW - Galphimines KW - Malpighiaceae KW - Single crystal X-ray diffraction SP - 112180 EP - 112180 JF - Phytochemistry JO - Phytochemistry VL - 169 N2 - Both DNA barcoding and phylogenetic data of the studied botanical material suggested the existence a new population of Galphimia glauca. Their leaves afforded three new nor-3,4-seco-friedelanes named galphimines M-O, together with known galphimines D, E, G, and I. Galphimines M and N possess bicyclic orthoacetates which are the first examples of orthoesters found in the Malpighiaceae family, while galphimine O has a 27,20-δ-lactone moiety. The structures elucidation followed from spectroscopic means and the absolute configuration followed from single crystal X-ray diffraction analyses. Tests for antibacterial and antifungal activities of galphimines N and M showed no promising effects. SN - 1873-3700 UR - https://www.unboundmedicine.com/medline/citation/31634725/Further_galphimines_from_a_new_population_of_Galphimia_glauca L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9422(19)30412-1 DB - PRIME DP - Unbound Medicine ER -