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TRPing the homeostatic alarm - Melanoma cells are selectively vulnerable to TRPML1 deletion.
Cell Calcium 2019; 84:102082CC

Abstract

To thrive in otherwise inhospitable conditions, cancer cells utilize endolysosomes to impose homeostatic control over cellular metabolism and growth. In a recent study, Kasitinon et al. demonstrate a requirement for the endolysosomal channel, TRPML1, in proliferation and survival of melanoma cells. This study adds to a growing list of cancers that exhibit selective vulnerability to the loss of TRPML1.

Authors+Show Affiliations

Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX 77030, USA.Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX 77030, USA; Graduate Program in Biochemistry and Cell Biology, MD Anderson Cancer Center and UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address: kartik.venkatachalam@uth.tmc.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31634759

Citation

Jung, Jewon, and Kartik Venkatachalam. "TRPing the Homeostatic Alarm - Melanoma Cells Are Selectively Vulnerable to TRPML1 Deletion." Cell Calcium, vol. 84, 2019, p. 102082.
Jung J, Venkatachalam K. TRPing the homeostatic alarm - Melanoma cells are selectively vulnerable to TRPML1 deletion. Cell Calcium. 2019;84:102082.
Jung, J., & Venkatachalam, K. (2019). TRPing the homeostatic alarm - Melanoma cells are selectively vulnerable to TRPML1 deletion. Cell Calcium, 84, p. 102082. doi:10.1016/j.ceca.2019.102082.
Jung J, Venkatachalam K. TRPing the Homeostatic Alarm - Melanoma Cells Are Selectively Vulnerable to TRPML1 Deletion. Cell Calcium. 2019 Oct 1;84:102082. PubMed PMID: 31634759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRPing the homeostatic alarm - Melanoma cells are selectively vulnerable to TRPML1 deletion. AU - Jung,Jewon, AU - Venkatachalam,Kartik, Y1 - 2019/10/01/ PY - 2019/09/17/received PY - 2019/09/18/revised PY - 2019/09/20/accepted PY - 2019/10/22/pubmed PY - 2019/10/22/medline PY - 2019/10/22/entrez SP - 102082 EP - 102082 JF - Cell calcium JO - Cell Calcium VL - 84 N2 - To thrive in otherwise inhospitable conditions, cancer cells utilize endolysosomes to impose homeostatic control over cellular metabolism and growth. In a recent study, Kasitinon et al. demonstrate a requirement for the endolysosomal channel, TRPML1, in proliferation and survival of melanoma cells. This study adds to a growing list of cancers that exhibit selective vulnerability to the loss of TRPML1. SN - 1532-1991 UR - https://www.unboundmedicine.com/medline/citation/31634759/TRPing_the_homeostatic_alarm_-_Melanoma_cells_are_selectively_vulnerable_to_TRPML1_deletion L2 - https://linkinghub.elsevier.com/retrieve/pii/S0143-4160(19)30149-6 DB - PRIME DP - Unbound Medicine ER -