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Sales data as a measure of antibiotics usage: Concepts, examples and discussion of influencing factors.

Abstract

Monitoring and surveillance of antimicrobial usage in animals is a public health concern and different methods are currently discussed widely in public, science and politics. The objective of the paper is to present the available methods of monitoring and to discuss possible differences in the assessment of the antibiotics treatment. Sales data are expressed as the average amount of substance per animal or kg live weight (e.g. population-corrected unit, PCU). The number of Defined Daily Doses (nDDDvet) is calculated by extrapolating sales data with average animal weights and defined drug doses to a number of treatments theoretically applied to animals. In contrast, the number of Used Daily Doses (nUDDvet) displays the actual number of treatments which have been applied. As sales data are relatively easily obtained, they are frequently used. However, their results are influenced by the composition of the population and by the dose of the substances. As both may vary strongly between countries, direct comparison of sales data between countries may be misleading. The concept of analysing sales data is shown by exemplarily using the methods in the ESVAC report 2015. The presentation of usage data in terms of nDDDvet or of nUDDvet increases the comparability of the data from different countries or time periods. Furthermore, fluoroquinolones and third-/fourth-generation cephalosporins which, among other substances, bare a potential risk for human health, are used at low doses. Hence, their use contributes to a sales reduction while contrasting the guidelines of prudent use. nDDDvet or nUDDvet have the ability to better reflect the treatment frequency and thus to better link antibiotics use to public health concerns. Quantification of antibiotics should assist to focus on prudent use of antimicrobials to reduce the burden of resistant bacteria and, thus, enhance public health, animal health and animal welfare.

Authors+Show Affiliations

Institute for Veterinary Epidemiology and Biostatistics, Freie Universität Berlin, Berlin, Germany.PHW-Zentrallabor, Visbek, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31634982

Citation

Merle, Roswitha, and Borris Meyer-Kühling. "Sales Data as a Measure of Antibiotics Usage: Concepts, Examples and Discussion of Influencing Factors." Veterinary Medicine and Science, 2019.
Merle R, Meyer-Kühling B. Sales data as a measure of antibiotics usage: Concepts, examples and discussion of influencing factors. Vet Med Sci. 2019.
Merle, R., & Meyer-Kühling, B. (2019). Sales data as a measure of antibiotics usage: Concepts, examples and discussion of influencing factors. Veterinary Medicine and Science, doi:10.1002/vms3.205.
Merle R, Meyer-Kühling B. Sales Data as a Measure of Antibiotics Usage: Concepts, Examples and Discussion of Influencing Factors. Vet Med Sci. 2019 Oct 21; PubMed PMID: 31634982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sales data as a measure of antibiotics usage: Concepts, examples and discussion of influencing factors. AU - Merle,Roswitha, AU - Meyer-Kühling,Borris, Y1 - 2019/10/21/ PY - 2019/10/22/entrez PY - 2019/10/22/pubmed PY - 2019/10/22/medline KW - PCU KW - antimicrobial consumption KW - cephalosporins KW - farm animals KW - quinolones KW - technical units JF - Veterinary medicine and science JO - Vet Med Sci N2 - Monitoring and surveillance of antimicrobial usage in animals is a public health concern and different methods are currently discussed widely in public, science and politics. The objective of the paper is to present the available methods of monitoring and to discuss possible differences in the assessment of the antibiotics treatment. Sales data are expressed as the average amount of substance per animal or kg live weight (e.g. population-corrected unit, PCU). The number of Defined Daily Doses (nDDDvet) is calculated by extrapolating sales data with average animal weights and defined drug doses to a number of treatments theoretically applied to animals. In contrast, the number of Used Daily Doses (nUDDvet) displays the actual number of treatments which have been applied. As sales data are relatively easily obtained, they are frequently used. However, their results are influenced by the composition of the population and by the dose of the substances. As both may vary strongly between countries, direct comparison of sales data between countries may be misleading. The concept of analysing sales data is shown by exemplarily using the methods in the ESVAC report 2015. The presentation of usage data in terms of nDDDvet or of nUDDvet increases the comparability of the data from different countries or time periods. Furthermore, fluoroquinolones and third-/fourth-generation cephalosporins which, among other substances, bare a potential risk for human health, are used at low doses. Hence, their use contributes to a sales reduction while contrasting the guidelines of prudent use. nDDDvet or nUDDvet have the ability to better reflect the treatment frequency and thus to better link antibiotics use to public health concerns. Quantification of antibiotics should assist to focus on prudent use of antimicrobials to reduce the burden of resistant bacteria and, thus, enhance public health, animal health and animal welfare. SN - 2053-1095 UR - https://www.unboundmedicine.com/medline/citation/31634982/Sales_data_as_a_measure_of_antibiotics_usage:_Concepts,_examples_and_discussion_of_influencing_factors L2 - https://doi.org/10.1002/vms3.205 DB - PRIME DP - Unbound Medicine ER -