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The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study.
J Orthop Surg Res. 2019 Oct 21; 14(1):328.JO

Abstract

BACKGROUND

Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear. Pathologically, many KBD changes are similar to those of osteoarthritis (OA). Therefore, this study aimed to identify changes in the levels of potential urinary biomarkers for OA, including C-telopeptide of type II collagen (uCTX-II), type II collagen cleavage neoepitope (uC2C), pyridinoline (uPYD), and uHelix-II, among adults with KBD.

METHODS

Urinary samples of 83 external control (EC) subjects, 91 KBD patients, and 86 internal control (IC) subjects were tested by ELISA after the subjects completed a questionnaire and X-ray examination.

RESULTS

The medians of the four markers in the KBD group were higher than those in the EC group and those in the IC group. The medians in the grade II KBD group were higher than those in the grade I group but were not statistically significant (P = 0.301, P = 0.408, P = 0.204, and P = 0.898 for uCTX-II, uC2C, uPYD, and uHelix-II, respectively). The area under the curve (AUC) of uCTX-II (0.775) was higher than that of the others (0.672, 0.639, and 0.628 for uC2C, uPYD, and uHelix-II, respectively).

CONCLUSION

The levels of uCTX-II, uC2C, uPYD, and uHelix-II were elevated in adults with KBD and showed an increasing trend as the severity of KBD increased. The prediction accuracy of uCTX-II was more useful than that of the others for assisting in the diagnosis of KBD.

Authors+Show Affiliations

Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China. Department of Human Resource, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen, 361004, Fujian, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, Heilongjiang, China.Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang, China. 6yujun@126.com. Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, 23618504, Heilongjiang, China. 6yujun@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31639015

Citation

Song, Quan Quan, et al. "The Urinary Levels of CTX-II, C2C, PYD, and Helix-II Increased Among Adults With KBD: a Cross-sectional Study." Journal of Orthopaedic Surgery and Research, vol. 14, no. 1, 2019, p. 328.
Song QQ, Sun LY, Li CH, et al. The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study. J Orthop Surg Res. 2019;14(1):328.
Song, Q. Q., Sun, L. Y., Li, C. H., Liu, Y. J., Cui, S. L., Liu, Y. Q., Cao, Y. H., Pei, J. R., Wang, Y., Lian, W., Jiao, Z., Deng, Q., & Yu, J. (2019). The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study. Journal of Orthopaedic Surgery and Research, 14(1), 328. https://doi.org/10.1186/s13018-019-1392-6
Song QQ, et al. The Urinary Levels of CTX-II, C2C, PYD, and Helix-II Increased Among Adults With KBD: a Cross-sectional Study. J Orthop Surg Res. 2019 Oct 21;14(1):328. PubMed PMID: 31639015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study. AU - Song,Quan Quan, AU - Sun,Li Yan, AU - Li,Chun Hui, AU - Liu,Yu Jiao, AU - Cui,Si Lu, AU - Liu,Yun Qi, AU - Cao,Yan Hong, AU - Pei,Jun Rui, AU - Wang,Yue, AU - Lian,Wei, AU - Jiao,Zhe, AU - Deng,Qing, AU - Yu,Jun, Y1 - 2019/10/21/ PY - 2019/04/09/received PY - 2019/09/24/accepted PY - 2019/10/23/entrez PY - 2019/10/23/pubmed PY - 2020/3/31/medline KW - Kashin-Beck disease KW - Osteoarthritis KW - Urinary biomarkers SP - 328 EP - 328 JF - Journal of orthopaedic surgery and research JO - J Orthop Surg Res VL - 14 IS - 1 N2 - BACKGROUND: Kashin-Beck disease (KBD) is an endemic osteoarthropathy, and its pathogenesis is still not entirely clear. Pathologically, many KBD changes are similar to those of osteoarthritis (OA). Therefore, this study aimed to identify changes in the levels of potential urinary biomarkers for OA, including C-telopeptide of type II collagen (uCTX-II), type II collagen cleavage neoepitope (uC2C), pyridinoline (uPYD), and uHelix-II, among adults with KBD. METHODS: Urinary samples of 83 external control (EC) subjects, 91 KBD patients, and 86 internal control (IC) subjects were tested by ELISA after the subjects completed a questionnaire and X-ray examination. RESULTS: The medians of the four markers in the KBD group were higher than those in the EC group and those in the IC group. The medians in the grade II KBD group were higher than those in the grade I group but were not statistically significant (P = 0.301, P = 0.408, P = 0.204, and P = 0.898 for uCTX-II, uC2C, uPYD, and uHelix-II, respectively). The area under the curve (AUC) of uCTX-II (0.775) was higher than that of the others (0.672, 0.639, and 0.628 for uC2C, uPYD, and uHelix-II, respectively). CONCLUSION: The levels of uCTX-II, uC2C, uPYD, and uHelix-II were elevated in adults with KBD and showed an increasing trend as the severity of KBD increased. The prediction accuracy of uCTX-II was more useful than that of the others for assisting in the diagnosis of KBD. SN - 1749-799X UR - https://www.unboundmedicine.com/medline/citation/31639015/The_urinary_levels_of_CTX-II,_C2C,_PYD,_and_Helix-II_increased_among_adults_with_KBD:_a_cross-sectional_study L2 - https://josr-online.biomedcentral.com/articles/10.1186/s13018-019-1392-6 DB - PRIME DP - Unbound Medicine ER -