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Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases.
Biochim Biophys Acta Rev Cancer 2020; 1873(1):188316BB

Abstract

The regulation of the pleiotropic transcription factor, nuclear factor-κB (NF-κB) by miRNAs and proteins is extensively studied. More recently, the NF-κB signaling was also reported to be regulated by several long non-coding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-κB associated lncRNAs include NKILA, HOTAIR, MALAT1, ANRIL, Lethe, MIR31HG, and PACER. The lncRNA and NF-κB signaling crosstalk during cancer and other diseases such as cardiomyopathy, celiac disease, cerebral infarction, chronic kidney disease, diabetes mellitus, Kawasaki disease, pregnancy loss, and rheumatoid arthritis. Some NF-κB related lncRNAs can affect gene expression without modulating NF-κB signaling. Most of the lncRNAs with a potential to modulate NF-κB signaling are regulated by NF-κB itself suggesting a feedback regulation. The discovery of lncRNAs have provided a new type of regulation for the NF-κB signaling and thus could be explored for therapeutic interventions. The manner in which lncRNA and NF-κB crosstalk affects human pathophysiology is discussed in this review. The challenges associated with the therapeutic interventions of this crosstalk are also discussed.

Authors+Show Affiliations

Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India. Electronic address: sgupta@bhu.ac.in.Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India.Department of Biochemistry & Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.Pediatric Oncology Laboratory, Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.Department of Biochemistry & Molecular Biology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: kishore.challagundla@unmc.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31639408

Citation

Gupta, Subash C., et al. "Long Non-coding RNAs and Nuclear factor-κB Crosstalk in Cancer and Other Human Diseases." Biochimica Et Biophysica Acta. Reviews On Cancer, vol. 1873, no. 1, 2020, p. 188316.
Gupta SC, Awasthee N, Rai V, et al. Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases. Biochim Biophys Acta Rev Cancer. 2020;1873(1):188316.
Gupta, S. C., Awasthee, N., Rai, V., Chava, S., Gunda, V., & Challagundla, K. B. (2020). Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases. Biochimica Et Biophysica Acta. Reviews On Cancer, 1873(1), p. 188316. doi:10.1016/j.bbcan.2019.188316.
Gupta SC, et al. Long Non-coding RNAs and Nuclear factor-κB Crosstalk in Cancer and Other Human Diseases. Biochim Biophys Acta Rev Cancer. 2020;1873(1):188316. PubMed PMID: 31639408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases. AU - Gupta,Subash C, AU - Awasthee,Nikee, AU - Rai,Vipin, AU - Chava,Srinivas, AU - Gunda,Venugopal, AU - Challagundla,Kishore B, Y1 - 2019/10/19/ PY - 2019/08/13/received PY - 2019/09/23/revised PY - 2019/09/23/accepted PY - 2019/10/23/pubmed PY - 2019/10/23/medline PY - 2019/10/23/entrez KW - Cancer KW - Chronic disease KW - LncRNA KW - NF-κB KW - Non-coding RNA SP - 188316 EP - 188316 JF - Biochimica et biophysica acta. Reviews on cancer JO - Biochim Biophys Acta Rev Cancer VL - 1873 IS - 1 N2 - The regulation of the pleiotropic transcription factor, nuclear factor-κB (NF-κB) by miRNAs and proteins is extensively studied. More recently, the NF-κB signaling was also reported to be regulated by several long non-coding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-κB associated lncRNAs include NKILA, HOTAIR, MALAT1, ANRIL, Lethe, MIR31HG, and PACER. The lncRNA and NF-κB signaling crosstalk during cancer and other diseases such as cardiomyopathy, celiac disease, cerebral infarction, chronic kidney disease, diabetes mellitus, Kawasaki disease, pregnancy loss, and rheumatoid arthritis. Some NF-κB related lncRNAs can affect gene expression without modulating NF-κB signaling. Most of the lncRNAs with a potential to modulate NF-κB signaling are regulated by NF-κB itself suggesting a feedback regulation. The discovery of lncRNAs have provided a new type of regulation for the NF-κB signaling and thus could be explored for therapeutic interventions. The manner in which lncRNA and NF-κB crosstalk affects human pathophysiology is discussed in this review. The challenges associated with the therapeutic interventions of this crosstalk are also discussed. SN - 1879-2561 UR - https://www.unboundmedicine.com/medline/citation/31639408/Long_non-coding_RNAs_and_nuclear_factor-κB_crosstalk_in_cancer_and_other_human_diseases L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-419X(19)30127-1 DB - PRIME DP - Unbound Medicine ER -