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Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to obesity: A population-based study.
Environ Int 2019; 133(Pt B):105191EI

Abstract

BACKGROUND

Perchlorate, nitrate, and thiocyanate are well-known thyroid disrupters and may contribute to changes in body weight. However, the associations between environmental exposure to these chemicals and obesity-related outcomes remain unclear.

OBJECTIVES

We aim to examine the urinary levels of perchlorate, nitrate, and thiocyanate and their associations with obesity and abdominal obesity in the U.S.

RESULTS

Overall, 5794 (35.6%) cases of obesity and 9090 cases (55.9%) of abdominal obesity were observed among the participants. In multivariable-adjusted logistic regression models, urinary nitrate was inversely associated with obesity (p = 0.0022 for trend), while urinary thiocyanate was positively related to obesity (p < 0.001 for trend). Compared with the lowest quartile, the odds ratios with 95% confidence intervals (CIs) across increasing quartiles were 0.95 (95% CI, 0.83-1.08), 0.88 (0.75-1.03), and 0.74 (0.60-0.90) for urinary nitrate and 1.31 (1.16-1.48), 1.53 (1.36-1.73), and 1.73 (1.47-2.03) for urinary thiocyanate. Urinary perchlorate was not correlated with obesity. Similar associations were also found between exposure to these chemicals and abdominal obesity.

CONCLUSIONS

A higher exposure to urinary nitrate was associated with a lower risk of obesity, while a positive association was observed for urinary thiocyanate. These findings emphasize the need to longitudinally evaluate environmental exposure to perchlorate, nitrate, and thiocyanate with respect to their effect on obesity in humans.

Authors+Show Affiliations

National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang, China.National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang, China.Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang, China.Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: y_zhang@zju.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31639604

Citation

Zhu, Fanghuan, et al. "Environmental Exposure to Perchlorate, Nitrate, and Thiocyanate in Relation to Obesity: a Population-based Study." Environment International, vol. 133, no. Pt B, 2019, p. 105191.
Zhu F, Huang M, Jiao J, et al. Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to obesity: A population-based study. Environ Int. 2019;133(Pt B):105191.
Zhu, F., Huang, M., Jiao, J., Zhuang, P., Mao, L., & Zhang, Y. (2019). Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to obesity: A population-based study. Environment International, 133(Pt B), p. 105191. doi:10.1016/j.envint.2019.105191.
Zhu F, et al. Environmental Exposure to Perchlorate, Nitrate, and Thiocyanate in Relation to Obesity: a Population-based Study. Environ Int. 2019;133(Pt B):105191. PubMed PMID: 31639604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to obesity: A population-based study. AU - Zhu,Fanghuan, AU - Huang,Mengmeng, AU - Jiao,Jingjing, AU - Zhuang,Pan, AU - Mao,Lei, AU - Zhang,Yu, Y1 - 2019/10/19/ PY - 2019/05/11/received PY - 2019/09/05/revised PY - 2019/09/13/accepted PY - 2019/10/23/pubmed PY - 2019/10/23/medline PY - 2019/10/23/entrez KW - Abdominal obesity KW - National Health and Nutrition Examination Survey KW - Nitrate KW - Obesity KW - Perchlorate KW - Thiocyanate SP - 105191 EP - 105191 JF - Environment international JO - Environ Int VL - 133 IS - Pt B N2 - BACKGROUND: Perchlorate, nitrate, and thiocyanate are well-known thyroid disrupters and may contribute to changes in body weight. However, the associations between environmental exposure to these chemicals and obesity-related outcomes remain unclear. OBJECTIVES: We aim to examine the urinary levels of perchlorate, nitrate, and thiocyanate and their associations with obesity and abdominal obesity in the U.S. RESULTS: Overall, 5794 (35.6%) cases of obesity and 9090 cases (55.9%) of abdominal obesity were observed among the participants. In multivariable-adjusted logistic regression models, urinary nitrate was inversely associated with obesity (p = 0.0022 for trend), while urinary thiocyanate was positively related to obesity (p < 0.001 for trend). Compared with the lowest quartile, the odds ratios with 95% confidence intervals (CIs) across increasing quartiles were 0.95 (95% CI, 0.83-1.08), 0.88 (0.75-1.03), and 0.74 (0.60-0.90) for urinary nitrate and 1.31 (1.16-1.48), 1.53 (1.36-1.73), and 1.73 (1.47-2.03) for urinary thiocyanate. Urinary perchlorate was not correlated with obesity. Similar associations were also found between exposure to these chemicals and abdominal obesity. CONCLUSIONS: A higher exposure to urinary nitrate was associated with a lower risk of obesity, while a positive association was observed for urinary thiocyanate. These findings emphasize the need to longitudinally evaluate environmental exposure to perchlorate, nitrate, and thiocyanate with respect to their effect on obesity in humans. SN - 1873-6750 UR - https://www.unboundmedicine.com/medline/citation/31639604/Environmental_exposure_to_perchlorate,_nitrate,_and_thiocyanate_in_relation_to_obesity:_A_population-based_study L2 - https://linkinghub.elsevier.com/retrieve/pii/S0160-4120(19)31593-4 DB - PRIME DP - Unbound Medicine ER -