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The LIBRA Index in Relation to Cognitive Function, Functional Independence, and Psycho-Behavioral Symptoms in a Sample of Non-Institutionalized Seniors at Risk of Dementia.
J Alzheimers Dis. 2019; 72(3):717-731.JA

Abstract

BACKGROUND

Alzheimer's disease is the principal cause of dementia and is determined, in at least one third cases, by modifiable risk factors (MRF). The "Lifestyle for Brain Health (LIBRA)" index was recently developed to quantify the individual risk of progression to dementia ascribable to MRF.

OBJECTIVE

The aim of this study was to investigate the association between LIBRA scores and markers of cognitive performance, functional independence, and psycho-behavioral symptoms in a community-based sample of Italian elders.

METHODS

308 senior participants with mild cognitive impairment (MCI) or subjective cognitive decline (SCD) were evaluated with a complete neuropsychological battery and semi-structured interviews for the assessment of depression, apathy, and functional autonomy. All the 12 LIBRA MRF were available for the calculation of LIBRA scores. A modified version of the index (LIBRA-2) was calculated by removing depression weight from the LIBRA index. Partial correlation analyses, controlling for age and education, assessed the association between LIBRA indices and cognitive, functional, and behavioral outcomes. Separate analyses were repeated in the MCI and SCD subgroups.

RESULTS

In participants with SCD (SCDp), significant correlations existed between LIBRA and markers of impairment in global cognition, visuo-spatial attention, and semantic fluency. LIBRA-2 associated with psycho-behavioral symptoms in the whole sample and in SCDp. LIBRA-2 only associated with apathy in the MCI subgroup.

CONCLUSIONS

The LIBRA index might be useful to determine the lifestyle-attributable risk of cognitive and psycho-behavioral decline in Italian seniors at risk, while in those with overt cognitive impairment, these outcomes are presumably mainly associated with non-modifiable factors.

Authors+Show Affiliations

Department of Clinical and Behavioral Neurology, Santa Lucia Foundation IRCCS, Rome, Italy. Department of Neuroscience, University of Rome "Tor Vergata", Rome, Italy.Institute of Biomedical Technologies, National Research Council, Milan, Italy.Department of Clinical and Behavioral Neurology, Santa Lucia Foundation IRCCS, Rome, Italy.Department of Surgical Sciences, University of Rome "Tor Vergata", Rome, Italy.Department of Clinical and Behavioral Neurology, Santa Lucia Foundation IRCCS, Rome, Italy.Department of Clinical and Behavioral Neurology, Santa Lucia Foundation IRCCS, Rome, Italy. Department of Neuroscience, University of Rome "Tor Vergata", Rome, Italy.Department of Clinical and Behavioral Neurology, Santa Lucia Foundation IRCCS, Rome, Italy. Department of Neuroscience, University of Rome "Tor Vergata", Rome, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31640092

Citation

Franchini, Flaminia, et al. "The LIBRA Index in Relation to Cognitive Function, Functional Independence, and Psycho-Behavioral Symptoms in a Sample of Non-Institutionalized Seniors at Risk of Dementia." Journal of Alzheimer's Disease : JAD, vol. 72, no. 3, 2019, pp. 717-731.
Franchini F, Musicco M, Ratto F, et al. The LIBRA Index in Relation to Cognitive Function, Functional Independence, and Psycho-Behavioral Symptoms in a Sample of Non-Institutionalized Seniors at Risk of Dementia. J Alzheimers Dis. 2019;72(3):717-731.
Franchini, F., Musicco, M., Ratto, F., Storti, G., Shofany, J., Caltagirone, C., & Di Santo, S. G. (2019). The LIBRA Index in Relation to Cognitive Function, Functional Independence, and Psycho-Behavioral Symptoms in a Sample of Non-Institutionalized Seniors at Risk of Dementia. Journal of Alzheimer's Disease : JAD, 72(3), 717-731. https://doi.org/10.3233/JAD-190495
Franchini F, et al. The LIBRA Index in Relation to Cognitive Function, Functional Independence, and Psycho-Behavioral Symptoms in a Sample of Non-Institutionalized Seniors at Risk of Dementia. J Alzheimers Dis. 2019;72(3):717-731. PubMed PMID: 31640092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The LIBRA Index in Relation to Cognitive Function, Functional Independence, and Psycho-Behavioral Symptoms in a Sample of Non-Institutionalized Seniors at Risk of Dementia. AU - Franchini,Flaminia, AU - Musicco,Massimo, AU - Ratto,Federica, AU - Storti,Gabriele, AU - Shofany,Jacob, AU - Caltagirone,Carlo, AU - Di Santo,Simona Gabriella, PY - 2019/10/24/pubmed PY - 2020/12/1/medline PY - 2019/10/24/entrez KW - Alzheimer’s disease KW - LIBRA Index KW - apathy KW - depression KW - mild cognitive impairment KW - modifiable risk factors KW - neuropsychological tests KW - subjective cognitive decline SP - 717 EP - 731 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 72 IS - 3 N2 - BACKGROUND: Alzheimer's disease is the principal cause of dementia and is determined, in at least one third cases, by modifiable risk factors (MRF). The "Lifestyle for Brain Health (LIBRA)" index was recently developed to quantify the individual risk of progression to dementia ascribable to MRF. OBJECTIVE: The aim of this study was to investigate the association between LIBRA scores and markers of cognitive performance, functional independence, and psycho-behavioral symptoms in a community-based sample of Italian elders. METHODS: 308 senior participants with mild cognitive impairment (MCI) or subjective cognitive decline (SCD) were evaluated with a complete neuropsychological battery and semi-structured interviews for the assessment of depression, apathy, and functional autonomy. All the 12 LIBRA MRF were available for the calculation of LIBRA scores. A modified version of the index (LIBRA-2) was calculated by removing depression weight from the LIBRA index. Partial correlation analyses, controlling for age and education, assessed the association between LIBRA indices and cognitive, functional, and behavioral outcomes. Separate analyses were repeated in the MCI and SCD subgroups. RESULTS: In participants with SCD (SCDp), significant correlations existed between LIBRA and markers of impairment in global cognition, visuo-spatial attention, and semantic fluency. LIBRA-2 associated with psycho-behavioral symptoms in the whole sample and in SCDp. LIBRA-2 only associated with apathy in the MCI subgroup. CONCLUSIONS: The LIBRA index might be useful to determine the lifestyle-attributable risk of cognitive and psycho-behavioral decline in Italian seniors at risk, while in those with overt cognitive impairment, these outcomes are presumably mainly associated with non-modifiable factors. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/31640092/The_LIBRA_Index_in_Relation_to_Cognitive_Function_Functional_Independence_and_Psycho_Behavioral_Symptoms_in_a_Sample_of_Non_Institutionalized_Seniors_at_Risk_of_Dementia_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-190495 DB - PRIME DP - Unbound Medicine ER -