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Identification of Opioids and Related Substances using Handheld Raman Spectrometers.
J Forensic Sci. 2020 Mar; 65(2):421-427.JF

Abstract

This study describes the performance of handheld Raman devices for detecting one hundred opioids and related substances including fentanyl and several analogs. Using a single "parent" device, signatures (spectra) with excellent signal-to-noise ratios were generated using <5 mg of most compounds. The signatures were added to a method (library), which was electronically transferred to three "daughter" devices. The devices were able to discriminate different salt forms and isomers. On average, the daughter devices yielded a true-positive rate of 97.3% for generating an alarm for opioids and were 93.3% effective for correctly identifying the opioid. The devices yielded true-negative, false-positive and false-negative rates of 100%, 0%, and 2.7%, respectively, where false negatives were due to weak signal and fluorescence. These data demonstrate that the parent-daughter electronic transfer method was successful and effective, which permits the ability to develop methods in the laboratory that can be seamlessly pushed out to field devices.

Authors+Show Affiliations

Forensic Chemistry Center, Office of Regulatory Science, Office of Regulatory Affairs, U.S. Food & Drug Administration, Cincinnati, OH, 45237.Forensic Chemistry Center, Office of Regulatory Science, Office of Regulatory Affairs, U.S. Food & Drug Administration, Cincinnati, OH, 45237.Forensic Chemistry Center, Office of Regulatory Science, Office of Regulatory Affairs, U.S. Food & Drug Administration, Cincinnati, OH, 45237.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31643087

Citation

Lanzarotta, Adam, et al. "Identification of Opioids and Related Substances Using Handheld Raman Spectrometers." Journal of Forensic Sciences, vol. 65, no. 2, 2020, pp. 421-427.
Lanzarotta A, Witkowski M, Batson J. Identification of Opioids and Related Substances using Handheld Raman Spectrometers. J Forensic Sci. 2020;65(2):421-427.
Lanzarotta, A., Witkowski, M., & Batson, J. (2020). Identification of Opioids and Related Substances using Handheld Raman Spectrometers. Journal of Forensic Sciences, 65(2), 421-427. https://doi.org/10.1111/1556-4029.14217
Lanzarotta A, Witkowski M, Batson J. Identification of Opioids and Related Substances Using Handheld Raman Spectrometers. J Forensic Sci. 2020;65(2):421-427. PubMed PMID: 31643087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of Opioids and Related Substances using Handheld Raman Spectrometers. AU - Lanzarotta,Adam, AU - Witkowski,Mark, AU - Batson,JaCinta, Y1 - 2019/10/23/ PY - 2019/08/01/received PY - 2019/09/10/revised PY - 2019/09/30/accepted PY - 2019/10/24/pubmed PY - 2020/3/12/medline PY - 2019/10/24/entrez KW - FDA KW - fentanyl KW - field testing KW - forensic science KW - handheld Raman KW - opioids SP - 421 EP - 427 JF - Journal of forensic sciences JO - J Forensic Sci VL - 65 IS - 2 N2 - This study describes the performance of handheld Raman devices for detecting one hundred opioids and related substances including fentanyl and several analogs. Using a single "parent" device, signatures (spectra) with excellent signal-to-noise ratios were generated using <5 mg of most compounds. The signatures were added to a method (library), which was electronically transferred to three "daughter" devices. The devices were able to discriminate different salt forms and isomers. On average, the daughter devices yielded a true-positive rate of 97.3% for generating an alarm for opioids and were 93.3% effective for correctly identifying the opioid. The devices yielded true-negative, false-positive and false-negative rates of 100%, 0%, and 2.7%, respectively, where false negatives were due to weak signal and fluorescence. These data demonstrate that the parent-daughter electronic transfer method was successful and effective, which permits the ability to develop methods in the laboratory that can be seamlessly pushed out to field devices. SN - 1556-4029 UR - https://www.unboundmedicine.com/medline/citation/31643087/Identification_of_Opioids_and_Related_Substances_using_Handheld_Raman_Spectrometers_ L2 - https://doi.org/10.1111/1556-4029.14217 DB - PRIME DP - Unbound Medicine ER -