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Characteristics of the Foveal Microvasculature in Asian Patients with Dry Age-Related Macular Degeneration: An Optical Coherence Tomography Angiography Study.
Ophthalmologica. 2020; 243(2):145-153.O

Abstract

PURPOSE

To evaluate changes in the foveal microvasculature in patients with dry age-related macular degeneration (dry AMD) using optical coherence tomography angiography (OCTA).

METHODS

Eighty-three eyes with dry AMD and 83 age- and sex-matched normal eyes were enrolled. A 3 × 3 mm2 OCTA (Zeiss HD-OCT 5000 with AngioPlex; Carl Zeiss Meditec, Dublin, CA, USA) scan was used to acquire images. Vessel density (VD), perfusion density (PD), and the foveal avascular zone (FAZ) of the superficial capillary plexus were analyzed.

RESULTS

The VD of the full area, central area, and inner ring of the dry AMD patients (18.61, 8.41, and 20.45, respectively) were significantly lower than those of the controls (20.06, 11.09, and 22.51, respectively). The PD of the full area, central area, and inner ring of the dry AMD patients (0.34, 0.15, and 0.37, respectively) were also significantly lower than those of the controls (0.36, 0.19, and 0.40, respectively). The FAZ area and perimeter in the dry AMD patients (0.29 mm2 and 2.47 mm, respectively) were larger than those in the controls (0.23 mm2 and 2.09 mm, respectively). The FAZ circularity index in the dry AMD patients was smaller than that in the controls (0.61 vs. 0.66). Using univariate linear regression, age, best-corrected visual acuity (BCVA), central macular thickness (CMT), and ganglion cell-inner plexiform layer (GC-IPL) thickness were associated with both VD and PD of the full area. Using multivariate analysis, only GC-IPL thickness was significantly associated with the VD and PD of the full area (p = 0.001 and p = 0.004, respectively).

CONCLUSIONS

OCTA revealed changes in the foveal microcirculation of patients with dry AMD. Age, BCVA, CMT, and GC-IPL thickness should be considered when analyzing the OCTA data of patients with dry AMD. GC-IPL thickness is particularly important during clinical evaluation of VD and PD in patients with dry AMD.

Authors+Show Affiliations

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea, kimjy@cnu.ac.kr.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

31645037

Citation

Shin, Yong-Il, et al. "Characteristics of the Foveal Microvasculature in Asian Patients With Dry Age-Related Macular Degeneration: an Optical Coherence Tomography Angiography Study." Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde, vol. 243, no. 2, 2020, pp. 145-153.
Shin YI, Kim JM, Lee MW, et al. Characteristics of the Foveal Microvasculature in Asian Patients with Dry Age-Related Macular Degeneration: An Optical Coherence Tomography Angiography Study. Ophthalmologica. 2020;243(2):145-153.
Shin, Y. I., Kim, J. M., Lee, M. W., Jo, Y. J., & Kim, J. Y. (2020). Characteristics of the Foveal Microvasculature in Asian Patients with Dry Age-Related Macular Degeneration: An Optical Coherence Tomography Angiography Study. Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde, 243(2), 145-153. https://doi.org/10.1159/000503295
Shin YI, et al. Characteristics of the Foveal Microvasculature in Asian Patients With Dry Age-Related Macular Degeneration: an Optical Coherence Tomography Angiography Study. Ophthalmologica. 2020;243(2):145-153. PubMed PMID: 31645037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of the Foveal Microvasculature in Asian Patients with Dry Age-Related Macular Degeneration: An Optical Coherence Tomography Angiography Study. AU - Shin,Yong-Il, AU - Kim,Ju Mi, AU - Lee,Min-Woo, AU - Jo,Young-Joon, AU - Kim,Jung-Yeul, Y1 - 2019/10/23/ PY - 2019/07/09/received PY - 2019/09/09/accepted PY - 2019/10/24/pubmed PY - 2021/1/29/medline PY - 2019/10/24/entrez KW - Dry age-related macular degeneration KW - Ganglion cell-inner plexiform layer KW - Optical coherence tomography angiography KW - Perfusion density KW - Vessel density SP - 145 EP - 153 JF - Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde JO - Ophthalmologica VL - 243 IS - 2 N2 - PURPOSE: To evaluate changes in the foveal microvasculature in patients with dry age-related macular degeneration (dry AMD) using optical coherence tomography angiography (OCTA). METHODS: Eighty-three eyes with dry AMD and 83 age- and sex-matched normal eyes were enrolled. A 3 × 3 mm2 OCTA (Zeiss HD-OCT 5000 with AngioPlex; Carl Zeiss Meditec, Dublin, CA, USA) scan was used to acquire images. Vessel density (VD), perfusion density (PD), and the foveal avascular zone (FAZ) of the superficial capillary plexus were analyzed. RESULTS: The VD of the full area, central area, and inner ring of the dry AMD patients (18.61, 8.41, and 20.45, respectively) were significantly lower than those of the controls (20.06, 11.09, and 22.51, respectively). The PD of the full area, central area, and inner ring of the dry AMD patients (0.34, 0.15, and 0.37, respectively) were also significantly lower than those of the controls (0.36, 0.19, and 0.40, respectively). The FAZ area and perimeter in the dry AMD patients (0.29 mm2 and 2.47 mm, respectively) were larger than those in the controls (0.23 mm2 and 2.09 mm, respectively). The FAZ circularity index in the dry AMD patients was smaller than that in the controls (0.61 vs. 0.66). Using univariate linear regression, age, best-corrected visual acuity (BCVA), central macular thickness (CMT), and ganglion cell-inner plexiform layer (GC-IPL) thickness were associated with both VD and PD of the full area. Using multivariate analysis, only GC-IPL thickness was significantly associated with the VD and PD of the full area (p = 0.001 and p = 0.004, respectively). CONCLUSIONS: OCTA revealed changes in the foveal microcirculation of patients with dry AMD. Age, BCVA, CMT, and GC-IPL thickness should be considered when analyzing the OCTA data of patients with dry AMD. GC-IPL thickness is particularly important during clinical evaluation of VD and PD in patients with dry AMD. SN - 1423-0267 UR - https://www.unboundmedicine.com/medline/citation/31645037/Characteristics_of_the_Foveal_Microvasculature_in_Asian_Patients_with_Dry_Age_Related_Macular_Degeneration:_An_Optical_Coherence_Tomography_Angiography_Study_ L2 - https://www.karger.com?DOI=10.1159/000503295 DB - PRIME DP - Unbound Medicine ER -