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Parental tobacco smoking and risk of childhood leukemia in Costa Rica: A population-based case-control study.
Environ Res. 2020 01; 180:108827.ER

Abstract

INTRODUCTION

The role of environmental and behavioral exposures on childhood leukemia etiology is poorly understood. We examined the association of maternal and paternal tobacco smoking at different time points with the risk of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in Costa Rican children.

MATERIALS AND METHODS

We conducted a population-based case-control study on childhood leukemia in Costa Rica. Cases (n ALL = 252; n AML = 40) were diagnosed between 1995 and 2000 (aged <15 years at diagnosis) and identified from the Costa Rican Cancer Registry and the National Children's Hospital. A total of 578 frequency-matched population controls were sampled from the National Birth Registry. Parental tobacco smoking was assessed via face-to-face interviews. We used logistic regression models to examine the association of paternal and maternal tobacco smoking before conception, during pregnancy, and after birth with childhood ALL and AML risk, adjusted for child sex, birth year, maternal/paternal age, and parental education.

RESULTS

Paternal smoking before conception, during pregnancy, and after birth was associated with an increased risk of childhood AML (Odds Ratio (OR): 2.51, 95% CI: 1.21-5.17; OR: 3.21, 95% CI: 1.56-6.60; and OR: 2.83, 95% CI: 1.36-5.90, respectively). Maternal smoking during pregnancy was also associated with a modest, but imprecise increase in AML risk. We observed null associations of maternal and paternal smoking with ALL in the offspring.

CONCLUSION

Our results suggest an association between parental smoking and risk of AML, but not ALL, in Costa Rican children. These findings add to the established evidence of numerous health risks associated with smoking and highlight the potential harm of smoking during sensitive windows of the development of fetus and child.

Authors+Show Affiliations

Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.Department of Occupational Medicine, Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden.Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health, Aarhus University and University Hospital, Aarhus, Denmark.Central American Institute for Studies on Toxic Substances (IRET), Universidad Nacional, Heredia, Costa Rica; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA. Electronic address: ana.mora.mora@una.cr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31655332

Citation

Frederiksen, Line Elmerdahl, et al. "Parental Tobacco Smoking and Risk of Childhood Leukemia in Costa Rica: a Population-based Case-control Study." Environmental Research, vol. 180, 2020, p. 108827.
Frederiksen LE, Erdmann F, Wesseling C, et al. Parental tobacco smoking and risk of childhood leukemia in Costa Rica: A population-based case-control study. Environ Res. 2020;180:108827.
Frederiksen, L. E., Erdmann, F., Wesseling, C., Winther, J. F., & Mora, A. M. (2020). Parental tobacco smoking and risk of childhood leukemia in Costa Rica: A population-based case-control study. Environmental Research, 180, 108827. https://doi.org/10.1016/j.envres.2019.108827
Frederiksen LE, et al. Parental Tobacco Smoking and Risk of Childhood Leukemia in Costa Rica: a Population-based Case-control Study. Environ Res. 2020;180:108827. PubMed PMID: 31655332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental tobacco smoking and risk of childhood leukemia in Costa Rica: A population-based case-control study. AU - Frederiksen,Line Elmerdahl, AU - Erdmann,Friederike, AU - Wesseling,Catharina, AU - Winther,Jeanette Falck, AU - Mora,Ana M, Y1 - 2019/10/16/ PY - 2019/06/28/received PY - 2019/10/11/revised PY - 2019/10/15/accepted PY - 2019/10/28/pubmed PY - 2020/9/5/medline PY - 2019/10/27/entrez KW - Childhood leukemia KW - Costa Rica KW - Early-life exposures KW - Hispanics KW - Parental smoking KW - Tobacco exposure SP - 108827 EP - 108827 JF - Environmental research JO - Environ Res VL - 180 N2 - INTRODUCTION: The role of environmental and behavioral exposures on childhood leukemia etiology is poorly understood. We examined the association of maternal and paternal tobacco smoking at different time points with the risk of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) in Costa Rican children. MATERIALS AND METHODS: We conducted a population-based case-control study on childhood leukemia in Costa Rica. Cases (n ALL = 252; n AML = 40) were diagnosed between 1995 and 2000 (aged <15 years at diagnosis) and identified from the Costa Rican Cancer Registry and the National Children's Hospital. A total of 578 frequency-matched population controls were sampled from the National Birth Registry. Parental tobacco smoking was assessed via face-to-face interviews. We used logistic regression models to examine the association of paternal and maternal tobacco smoking before conception, during pregnancy, and after birth with childhood ALL and AML risk, adjusted for child sex, birth year, maternal/paternal age, and parental education. RESULTS: Paternal smoking before conception, during pregnancy, and after birth was associated with an increased risk of childhood AML (Odds Ratio (OR): 2.51, 95% CI: 1.21-5.17; OR: 3.21, 95% CI: 1.56-6.60; and OR: 2.83, 95% CI: 1.36-5.90, respectively). Maternal smoking during pregnancy was also associated with a modest, but imprecise increase in AML risk. We observed null associations of maternal and paternal smoking with ALL in the offspring. CONCLUSION: Our results suggest an association between parental smoking and risk of AML, but not ALL, in Costa Rican children. These findings add to the established evidence of numerous health risks associated with smoking and highlight the potential harm of smoking during sensitive windows of the development of fetus and child. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/31655332/Parental_tobacco_smoking_and_risk_of_childhood_leukemia_in_Costa_Rica:_A_population_based_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(19)30624-3 DB - PRIME DP - Unbound Medicine ER -