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Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine.

Abstract

Background

Paraneoplastic chorea is typically a subacute progressive hyperkinetic movement disorder. The mainstay of treatment is managing the underlying neoplasm. However, the clinical course may be variable, and effective symptomatic management can precede the start of cancer treatment.

Case report

A 63-year-old man presented with insidious onset, slowly progressive generalized chorea for 1 year, later diagnosed as anti-CV2/CRMP5 autoantibody positive paraneoplastic chorea. His chorea was markedly improved with intravenous amantadine.

Discussion

In patients with anti-CV2/CRMP5 autoantibody-related chorea, sequential follow-up of brain magnetic resonance imaging reveals progression from active inflammation to atrophy. Our report highlights the efficacy of intravenous amantadine in paraneoplastic chorea.

Authors+Show Affiliations

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KR. Neuroscience Center, Samsung Medical Center, Seoul, KR.Department of Neurology, Dongshin Hospital, Seoul, KR.Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KR. Neuroscience Center, Samsung Medical Center, Seoul, KR.Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KR. Neuroscience Center, Samsung Medical Center, Seoul, KR.Department of Neurology, Dong-A University College of Medicine, Busan, KR.Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, KR.Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KR. Neuroscience Center, Samsung Medical Center, Seoul, KR.Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KR. Neuroscience Center, Samsung Medical Center, Seoul, KR.Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KR. Neuroscience Center, Samsung Medical Center, Seoul, KR.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31656691

Citation

Ha, Jongmok, et al. "Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed With Intravenous Amantadine." Tremor and Other Hyperkinetic Movements (New York, N.Y.), vol. 9, 2019.
Ha J, Na BS, Ahn JH, et al. Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine. Tremor Other Hyperkinet Mov (N Y). 2019;9.
Ha, J., Na, B. S., Ahn, J. H., Kim, M., Kim, J. W., Lee, J. H., Cho, J. W., Kim, J. S., & Youn, J. (2019). Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine. Tremor and Other Hyperkinetic Movements (New York, N.Y.), 9. https://doi.org/10.7916/tohm.v0.701
Ha J, et al. Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed With Intravenous Amantadine. Tremor Other Hyperkinet Mov (N Y). 2019;9 PubMed PMID: 31656691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-CV2/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine. AU - Ha,Jongmok, AU - Na,Boo Suk, AU - Ahn,Jong Hyeon, AU - Kim,Minkyeong, AU - Kim,Jae Woo, AU - Lee,Jae Hyeok, AU - Cho,Jin Whan, AU - Kim,Ji Sun, AU - Youn,Jinyoung, Y1 - 2019/10/10/ PY - 2019/07/04/received PY - 2019/09/16/accepted PY - 2019/10/29/entrez PY - 2019/10/28/pubmed PY - 2020/9/20/medline KW - CRMP5 KW - CV2 KW - Paraneoplastic KW - autoimmune KW - chorea JF - Tremor and other hyperkinetic movements (New York, N.Y.) JO - Tremor Other Hyperkinet Mov (N Y) VL - 9 N2 - Background: Paraneoplastic chorea is typically a subacute progressive hyperkinetic movement disorder. The mainstay of treatment is managing the underlying neoplasm. However, the clinical course may be variable, and effective symptomatic management can precede the start of cancer treatment. Case report: A 63-year-old man presented with insidious onset, slowly progressive generalized chorea for 1 year, later diagnosed as anti-CV2/CRMP5 autoantibody positive paraneoplastic chorea. His chorea was markedly improved with intravenous amantadine. Discussion: In patients with anti-CV2/CRMP5 autoantibody-related chorea, sequential follow-up of brain magnetic resonance imaging reveals progression from active inflammation to atrophy. Our report highlights the efficacy of intravenous amantadine in paraneoplastic chorea. SN - 2160-8288 UR - https://www.unboundmedicine.com/medline/citation/31656691/Anti_CV2/CRMP5_Paraneoplastic_Chorea_Effectively_Managed_with_Intravenous_Amantadine_ L2 - http://dx.doi.org/doi:10.7916/tohm.v0.701 DB - PRIME DP - Unbound Medicine ER -