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Effects of resveratrol on intestinal oxidative status and inflammation in heat-stressed rats.
J Therm Biol. 2019 Oct; 85:102415.JT

Abstract

Heat stress, experienced by humans and animals under high ambient temperatures, is known to induce oxidative stress and inflammation, which endangers human health as well as animal welfare and production. The gastrointestinal tract is predominantly responsive to heat stress and compromised intestinal functions can contribute to multi-organ injury under heat environment. Resveratrol (RSV) has significant antioxidant and anti-inflammatory activities. The aim of this study was to investigate the potential effects of RSV on intestinal function (digestion and barrier), oxidative stress and inflammation in heat-stressed rats. Male Sprague-Dawley rats were orally fed with 100 mg RSV/kg body weight/day prior to daily heat stress (40 °C per day for 1.5 h) exposure for 3 consecutive days. The results showed that RSV reversed the increased serum cortisol level and diamine oxidase activity, the altered jejunal morphology, the decreased jejunal disaccharidase activities, the elevated malondialdehyde and tumor necrosis factor alpha concentrations and antioxidant enzymes activities in the jejunum, as well as the increased jejunal mRNA expression of toll-like receptor 4, cytokines, antioxidant enzymes and tight junction proteins in heat-stressed rats, to various degrees. In conclusion, RSV could alleviate intestinal injury and dysfunctions by improving oxidative status and suppressing inflammation in heat-stressed rats.

Authors+Show Affiliations

College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China.College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of China. Electronic address: tianwangnjau@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31657756

Citation

Cheng, Kang, et al. "Effects of Resveratrol On Intestinal Oxidative Status and Inflammation in Heat-stressed Rats." Journal of Thermal Biology, vol. 85, 2019, p. 102415.
Cheng K, Song Z, Li S, et al. Effects of resveratrol on intestinal oxidative status and inflammation in heat-stressed rats. J Therm Biol. 2019;85:102415.
Cheng, K., Song, Z., Li, S., Yan, E., Zhang, H., Zhang, L., Wang, C., & Wang, T. (2019). Effects of resveratrol on intestinal oxidative status and inflammation in heat-stressed rats. Journal of Thermal Biology, 85, 102415. https://doi.org/10.1016/j.jtherbio.2019.102415
Cheng K, et al. Effects of Resveratrol On Intestinal Oxidative Status and Inflammation in Heat-stressed Rats. J Therm Biol. 2019;85:102415. PubMed PMID: 31657756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of resveratrol on intestinal oxidative status and inflammation in heat-stressed rats. AU - Cheng,Kang, AU - Song,Zhihua, AU - Li,Simian, AU - Yan,Enfa, AU - Zhang,Hao, AU - Zhang,Lili, AU - Wang,Chao, AU - Wang,Tian, Y1 - 2019/09/10/ PY - 2019/05/06/received PY - 2019/07/07/revised PY - 2019/09/09/accepted PY - 2019/10/29/entrez PY - 2019/10/29/pubmed PY - 2020/3/19/medline KW - Heat stress KW - Inflammation KW - Intestine KW - Oxidative status KW - Rats KW - Resveratrol SP - 102415 EP - 102415 JF - Journal of thermal biology JO - J. Therm. Biol. VL - 85 N2 - Heat stress, experienced by humans and animals under high ambient temperatures, is known to induce oxidative stress and inflammation, which endangers human health as well as animal welfare and production. The gastrointestinal tract is predominantly responsive to heat stress and compromised intestinal functions can contribute to multi-organ injury under heat environment. Resveratrol (RSV) has significant antioxidant and anti-inflammatory activities. The aim of this study was to investigate the potential effects of RSV on intestinal function (digestion and barrier), oxidative stress and inflammation in heat-stressed rats. Male Sprague-Dawley rats were orally fed with 100 mg RSV/kg body weight/day prior to daily heat stress (40 °C per day for 1.5 h) exposure for 3 consecutive days. The results showed that RSV reversed the increased serum cortisol level and diamine oxidase activity, the altered jejunal morphology, the decreased jejunal disaccharidase activities, the elevated malondialdehyde and tumor necrosis factor alpha concentrations and antioxidant enzymes activities in the jejunum, as well as the increased jejunal mRNA expression of toll-like receptor 4, cytokines, antioxidant enzymes and tight junction proteins in heat-stressed rats, to various degrees. In conclusion, RSV could alleviate intestinal injury and dysfunctions by improving oxidative status and suppressing inflammation in heat-stressed rats. SN - 0306-4565 UR - https://www.unboundmedicine.com/medline/citation/31657756/Effects_of_resveratrol_on_intestinal_oxidative_status_and_inflammation_in_heat-stressed_rats L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4565(19)30249-9 DB - PRIME DP - Unbound Medicine ER -