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Polyneuropathy and the sural/radial sensory nerve action potential ratio in primary Sjögren's syndrome.
Neurol Res. 2020 Jan; 42(1):17-21.NR

Abstract

Objectives:

Polyneuropathy is the most common neurological complication in primary Sjögren's syndrome (pSS). A ratio of sural nerve and superficial radial nerve sensorial action potential amplitudes (SRARs) of <0.4 is an indicator for early axonal neuropathy. We evaluated the polyneuropathies and SRARs in pSS patients.Method: Fifty-two female patients who were diagnosed with pSS according to the European-American Consensus Criteria and 45 healthy controls were enrolled. Nerve conduction studies were performed to diagnose polyneuropathy. Sensory axonal polyneuropathy was diagnosed in three patients, so SRARs were compared in 49 patients and 50 healthy controls.

Results:

Fifty-two patients with pSS underwent nerve conduction tests. The sural sensory nerve action potential (SNAP) was <6 µV in threepatients and they were diagnosed with sensory axonal neuropathy. SRARs were evaluated in 49 female patients, with a mean age of 51.98 ± 10.79 years and 50 healthy controls with a mean age of 50.52 ± 12.55 years. The mean disease duration was 7.59 ± 6.17 years. The SRAR values were different between the patient and control groups. SRAR was <0.4 in 20.4% of the patient group and <0.4 in 6% of the control group. The SRAR value was not statistically different within the patient group based on anti-Ro and anti-La.Discussion: The potential for neurological involvement in patients with pSS who have no signs or injury should be evaluated because nervous system involvement in pSS is a negative prognostic factor. SRAR in patients with pSS can be used as a marker for the early detection of axonal neuropathy.

Authors+Show Affiliations

Diskapi Yildirim Beyazit Training and Research Hospital, Neurology, Health Sciences University, Ankara, Turkey.Diskapi Yildirim Beyazit Training and Research Hospital, Neurology, Health Sciences University, Ankara, Turkey.Diskapi Yildirim Beyazit Training and Research Hospital, Rheumatology, Health Sciences University, Ankara, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31661424

Citation

Eren, Yasemin, et al. "Polyneuropathy and the Sural/radial Sensory Nerve Action Potential Ratio in Primary Sjögren's Syndrome." Neurological Research, vol. 42, no. 1, 2020, pp. 17-21.
Eren Y, Yavasoglu NG, Ozisler C. Polyneuropathy and the sural/radial sensory nerve action potential ratio in primary Sjögren's syndrome. Neurol Res. 2020;42(1):17-21.
Eren, Y., Yavasoglu, N. G., & Ozisler, C. (2020). Polyneuropathy and the sural/radial sensory nerve action potential ratio in primary Sjögren's syndrome. Neurological Research, 42(1), 17-21. https://doi.org/10.1080/01616412.2019.1680126
Eren Y, Yavasoglu NG, Ozisler C. Polyneuropathy and the Sural/radial Sensory Nerve Action Potential Ratio in Primary Sjögren's Syndrome. Neurol Res. 2020;42(1):17-21. PubMed PMID: 31661424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyneuropathy and the sural/radial sensory nerve action potential ratio in primary Sjögren's syndrome. AU - Eren,Yasemin, AU - Yavasoglu,Nese Gungor, AU - Ozisler,Cem, Y1 - 2019/10/29/ PY - 2019/10/30/pubmed PY - 2020/11/12/medline PY - 2019/10/30/entrez KW - Sjogren KW - polyneuropathy KW - sural-radial ratio SP - 17 EP - 21 JF - Neurological research JO - Neurol Res VL - 42 IS - 1 N2 - Objectives: Polyneuropathy is the most common neurological complication in primary Sjögren's syndrome (pSS). A ratio of sural nerve and superficial radial nerve sensorial action potential amplitudes (SRARs) of <0.4 is an indicator for early axonal neuropathy. We evaluated the polyneuropathies and SRARs in pSS patients.Method: Fifty-two female patients who were diagnosed with pSS according to the European-American Consensus Criteria and 45 healthy controls were enrolled. Nerve conduction studies were performed to diagnose polyneuropathy. Sensory axonal polyneuropathy was diagnosed in three patients, so SRARs were compared in 49 patients and 50 healthy controls.Results: Fifty-two patients with pSS underwent nerve conduction tests. The sural sensory nerve action potential (SNAP) was <6 µV in threepatients and they were diagnosed with sensory axonal neuropathy. SRARs were evaluated in 49 female patients, with a mean age of 51.98 ± 10.79 years and 50 healthy controls with a mean age of 50.52 ± 12.55 years. The mean disease duration was 7.59 ± 6.17 years. The SRAR values were different between the patient and control groups. SRAR was <0.4 in 20.4% of the patient group and <0.4 in 6% of the control group. The SRAR value was not statistically different within the patient group based on anti-Ro and anti-La.Discussion: The potential for neurological involvement in patients with pSS who have no signs or injury should be evaluated because nervous system involvement in pSS is a negative prognostic factor. SRAR in patients with pSS can be used as a marker for the early detection of axonal neuropathy. SN - 1743-1328 UR - https://www.unboundmedicine.com/medline/citation/31661424/Polyneuropathy_and_the_sural/radial_sensory_nerve_action_potential_ratio_in_primary_Sjögren's_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.1080/01616412.2019.1680126 DB - PRIME DP - Unbound Medicine ER -