Tags

Type your tag names separated by a space and hit enter

Effects of a low saturated fat, low cholesterol fish oil supplement in hypertriglyceridemic patients. A placebo-controlled trial.
Ann Intern Med 1988; 109(6):465-70AIM

Abstract

STUDY OBJECTIVE

To determine the effects of fish oil supplements low in saturated fat and cholesterol on plasma lipid and lipoprotein levels in hypertriglyceridemic patients.

DESIGN

Single-blind, placebo-controlled (safflower oil), crossover trial with 6-week treatment periods.

SETTING

Outpatient lipid clinic in a university medical center.

PATIENTS

Eleven adult patients had isolated hypertriglyceridemia (type IV) and seven had concomitant hypercholesterolemia (Type IIb).

INTERVENTION

Twelve 1-g capsules of either fish oil or placebo (safflower oil) were taken daily during each treatment period.

MEASUREMENTS AND MAIN RESULTS

Blood was drawn at the fifth and sixth week of each period and analyzed for total lipids; cholesterol in very low, low (LDL), and high density (HDL) lipoproteins (mmol/L); and apoprotein B (mg/dL). Compared with the placebo, fish oil lowered plasma triglyceride levels (4.0 +/- 1.8 to 2.5 +/- 1.0), and raised LDL cholesterol levels (3.7 +/- 1.75 to 4.25 +/- 0.85), apolipoprotein B levels (122 +/- 29 to 140 +/- 34), and the ratio of LDL cholesterol to HDL cholesterol (4.0 +/- 0.9 to 4.7 +/- 1.4) (P less than 0.05; mean +/- SD). No significant changes were seen in levels of HDL or HDL cholesterol subfractions. Similar responses were seen in patients with both type IIb and IV lipoprotein phenotypes.

CONCLUSIONS

Because the fish oil supplement contributed negligible amounts of cholesterol and saturated fat to the diet, the n-3 fatty acids most likely caused the observed effects. These findings indicate that relatively small amounts of fish oil can have beneficial effects on plasma triglyceride levels in hypertriglyceridemic patients, but the increase in LDL cholesterol and apoprotein B levels, and in the LDL cholesterol to HDL cholesterol ratio suggests the need for careful monitoring of plasma lipoprotein changes during fish oil supplementation, and for a careful evaluation of their long-term benefits.

Authors+Show Affiliations

University of Kansas Medical Center, Kansas City.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3166357

Citation

Harris, W S., et al. "Effects of a Low Saturated Fat, Low Cholesterol Fish Oil Supplement in Hypertriglyceridemic Patients. a Placebo-controlled Trial." Annals of Internal Medicine, vol. 109, no. 6, 1988, pp. 465-70.
Harris WS, Dujovne CA, Zucker M, et al. Effects of a low saturated fat, low cholesterol fish oil supplement in hypertriglyceridemic patients. A placebo-controlled trial. Ann Intern Med. 1988;109(6):465-70.
Harris, W. S., Dujovne, C. A., Zucker, M., & Johnson, B. (1988). Effects of a low saturated fat, low cholesterol fish oil supplement in hypertriglyceridemic patients. A placebo-controlled trial. Annals of Internal Medicine, 109(6), pp. 465-70.
Harris WS, et al. Effects of a Low Saturated Fat, Low Cholesterol Fish Oil Supplement in Hypertriglyceridemic Patients. a Placebo-controlled Trial. Ann Intern Med. 1988 Sep 15;109(6):465-70. PubMed PMID: 3166357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a low saturated fat, low cholesterol fish oil supplement in hypertriglyceridemic patients. A placebo-controlled trial. AU - Harris,W S, AU - Dujovne,C A, AU - Zucker,M, AU - Johnson,B, PY - 1988/9/15/pubmed PY - 1988/9/15/medline PY - 1988/9/15/entrez SP - 465 EP - 70 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 109 IS - 6 N2 - STUDY OBJECTIVE: To determine the effects of fish oil supplements low in saturated fat and cholesterol on plasma lipid and lipoprotein levels in hypertriglyceridemic patients. DESIGN: Single-blind, placebo-controlled (safflower oil), crossover trial with 6-week treatment periods. SETTING: Outpatient lipid clinic in a university medical center. PATIENTS: Eleven adult patients had isolated hypertriglyceridemia (type IV) and seven had concomitant hypercholesterolemia (Type IIb). INTERVENTION: Twelve 1-g capsules of either fish oil or placebo (safflower oil) were taken daily during each treatment period. MEASUREMENTS AND MAIN RESULTS: Blood was drawn at the fifth and sixth week of each period and analyzed for total lipids; cholesterol in very low, low (LDL), and high density (HDL) lipoproteins (mmol/L); and apoprotein B (mg/dL). Compared with the placebo, fish oil lowered plasma triglyceride levels (4.0 +/- 1.8 to 2.5 +/- 1.0), and raised LDL cholesterol levels (3.7 +/- 1.75 to 4.25 +/- 0.85), apolipoprotein B levels (122 +/- 29 to 140 +/- 34), and the ratio of LDL cholesterol to HDL cholesterol (4.0 +/- 0.9 to 4.7 +/- 1.4) (P less than 0.05; mean +/- SD). No significant changes were seen in levels of HDL or HDL cholesterol subfractions. Similar responses were seen in patients with both type IIb and IV lipoprotein phenotypes. CONCLUSIONS: Because the fish oil supplement contributed negligible amounts of cholesterol and saturated fat to the diet, the n-3 fatty acids most likely caused the observed effects. These findings indicate that relatively small amounts of fish oil can have beneficial effects on plasma triglyceride levels in hypertriglyceridemic patients, but the increase in LDL cholesterol and apoprotein B levels, and in the LDL cholesterol to HDL cholesterol ratio suggests the need for careful monitoring of plasma lipoprotein changes during fish oil supplementation, and for a careful evaluation of their long-term benefits. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/3166357/Effects_of_a_low_saturated_fat_low_cholesterol_fish_oil_supplement_in_hypertriglyceridemic_patients__A_placebo_controlled_trial_ L2 - https://www.annals.org/aim/fullarticle/doi/10.7326/0003-4819-109-6-465 DB - PRIME DP - Unbound Medicine ER -