Tags

Type your tag names separated by a space and hit enter

Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence tomography in patients with mild cognitive impairment.
Alzheimers Dement (Amst). 2019 Dec; 11:659-669.AD

Abstract

Introduction

We compared peripapillary retinal nerve fiber layer and macular thickness measurements in patients with mild cognitive impairment (MCI) and control subjects using swept-source optical coherence tomography (SS-OCT). We also assessed the relationship between SS-OCT measurements and the severity of cognitive impairment.

Methods

Peripapillary retinal nerve fiber layer and macular thickness were measured in 23 patients and 24 control subjects using SS-OCT. Cognitive status was assessed using the Mini-Mental State Examination, the Montreal Cognitive Assessment, and the Pfeffer Questionnaire.

Results

Most inner retinal layer thickness parameters were significantly smaller in patients with MCI, especially macular ganglion cell complex thickness measurements. Mini-Mental State Examination and Montreal Cognitive Assessment findings were significantly correlated with most macular thickness parameters.

Discussion

The SS-OCT-measured inner retinal layers of patients with MCI displayed thinning, especially in the central macular area. SS-OCT technology can provide useful information on ocular involvement patterns and holds promise as an ocular biomarker in this patient population.

Authors+Show Affiliations

Department of Neurology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil.Department of Neurology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil.Department of Ophthalmology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil.Juiz de Fora Eye Hospital, Juiz de Fora, Minas Gerais, Brazil.Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.Department of Ophthalmology, Federal University of Juiz de Fora Medical School, Juiz de Fora, Minas Gerais, Brazil. Juiz de Fora Eye Hospital, Juiz de Fora, Minas Gerais, Brazil. Division of Ophthalmology, University of São Paulo Medical School, São Paulo, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31667327

Citation

Almeida, Ana L M., et al. "Correlation Between Cognitive Impairment and Retinal Neural Loss Assessed By Swept-source Optical Coherence Tomography in Patients With Mild Cognitive Impairment." Alzheimer's & Dementia (Amsterdam, Netherlands), vol. 11, 2019, pp. 659-669.
Almeida ALM, Pires LA, Figueiredo EA, et al. Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence tomography in patients with mild cognitive impairment. Alzheimers Dement (Amst). 2019;11:659-669.
Almeida, A. L. M., Pires, L. A., Figueiredo, E. A., Costa-Cunha, L. V. F., Zacharias, L. C., Preti, R. C., Monteiro, M. L. R., & Cunha, L. P. (2019). Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence tomography in patients with mild cognitive impairment. Alzheimer's & Dementia (Amsterdam, Netherlands), 11, 659-669. https://doi.org/10.1016/j.dadm.2019.08.006
Almeida ALM, et al. Correlation Between Cognitive Impairment and Retinal Neural Loss Assessed By Swept-source Optical Coherence Tomography in Patients With Mild Cognitive Impairment. Alzheimers Dement (Amst). 2019;11:659-669. PubMed PMID: 31667327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between cognitive impairment and retinal neural loss assessed by swept-source optical coherence tomography in patients with mild cognitive impairment. AU - Almeida,Ana L M, AU - Pires,Leopoldo A, AU - Figueiredo,Evelyn A, AU - Costa-Cunha,Luciana V F, AU - Zacharias,Leandro C, AU - Preti,Rony C, AU - Monteiro,Mário L R, AU - Cunha,Leonardo P, Y1 - 2019/09/25/ PY - 2019/11/1/entrez PY - 2019/11/2/pubmed PY - 2019/11/2/medline KW - Alzheimer's disease KW - Dementia KW - Ganglion cell layer KW - Macula KW - Mild cognitive impairment KW - Optic nerve KW - Optical coherence tomography KW - Retina KW - Retinal nerve fiber layer KW - Swept-source SP - 659 EP - 669 JF - Alzheimer's & dementia (Amsterdam, Netherlands) JO - Alzheimers Dement (Amst) VL - 11 N2 - Introduction: We compared peripapillary retinal nerve fiber layer and macular thickness measurements in patients with mild cognitive impairment (MCI) and control subjects using swept-source optical coherence tomography (SS-OCT). We also assessed the relationship between SS-OCT measurements and the severity of cognitive impairment. Methods: Peripapillary retinal nerve fiber layer and macular thickness were measured in 23 patients and 24 control subjects using SS-OCT. Cognitive status was assessed using the Mini-Mental State Examination, the Montreal Cognitive Assessment, and the Pfeffer Questionnaire. Results: Most inner retinal layer thickness parameters were significantly smaller in patients with MCI, especially macular ganglion cell complex thickness measurements. Mini-Mental State Examination and Montreal Cognitive Assessment findings were significantly correlated with most macular thickness parameters. Discussion: The SS-OCT-measured inner retinal layers of patients with MCI displayed thinning, especially in the central macular area. SS-OCT technology can provide useful information on ocular involvement patterns and holds promise as an ocular biomarker in this patient population. SN - 2352-8729 UR - https://www.unboundmedicine.com/medline/citation/31667327/Correlation_between_cognitive_impairment_and_retinal_neural_loss_assessed_by_swept_source_optical_coherence_tomography_in_patients_with_mild_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2352-8729(19)30064-8 DB - PRIME DP - Unbound Medicine ER -