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Risk of breast cancer in relation to reproductive factors in Denmark.
Br J Cancer 1988; 58(1):99-104BJ

Abstract

The effect of reproductive factors on breast cancer risk was evaluated in a population-based case-control study, including 1,486 breast cancer cases diagnosed over a one-year period in Denmark. They were identified from the files of the nationwide trial of the Danish Breast Cancer Co-operative group and the Danish Cancer Registry. The control group was an age-stratified random sample of 1,336 women from the general population. Data on risk factors were collected by self-administered (mailed) questionnaires. Significantly increased relative risks (RR) were associated with never being pregnant (RR = 1.47), an early terminated first pregnancy (RR = 1.43), and having a natural menopause after the age of 54 (RR = 1.67). Trends of decreasing risk were observed by increasing parity and age at menarche. These findings were independent of age at first full-term pregnancy which overall was not related to breast cancer risk, though a weak association appeared in women less than 50 years at diagnosis. The study confirmed that pregnancies must continue to term to offer protection against breast cancer.

Authors+Show Affiliations

Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3166899

Citation

Ewertz, M, and S W. Duffy. "Risk of Breast Cancer in Relation to Reproductive Factors in Denmark." British Journal of Cancer, vol. 58, no. 1, 1988, pp. 99-104.
Ewertz M, Duffy SW. Risk of breast cancer in relation to reproductive factors in Denmark. Br J Cancer. 1988;58(1):99-104.
Ewertz, M., & Duffy, S. W. (1988). Risk of breast cancer in relation to reproductive factors in Denmark. British Journal of Cancer, 58(1), pp. 99-104.
Ewertz M, Duffy SW. Risk of Breast Cancer in Relation to Reproductive Factors in Denmark. Br J Cancer. 1988;58(1):99-104. PubMed PMID: 3166899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of breast cancer in relation to reproductive factors in Denmark. AU - Ewertz,M, AU - Duffy,S W, PY - 1988/7/1/pubmed PY - 1988/7/1/medline PY - 1988/7/1/entrez KW - Abortion, Induced KW - Age Factors KW - Breast Cancer KW - Cancer KW - Comparative Studies KW - Demographic Factors KW - Denmark KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Fertility Control, Postconception KW - Incidence KW - Measurement KW - Neoplasms KW - Northern Europe KW - Population KW - Population Characteristics KW - Pregnancy--beneficial effects KW - Reproduction KW - Research Methodology KW - Scandinavia KW - Studies SP - 99 EP - 104 JF - British journal of cancer JO - Br. J. Cancer VL - 58 IS - 1 N2 - The effect of reproductive factors on breast cancer risk was evaluated in a population-based case-control study, including 1,486 breast cancer cases diagnosed over a one-year period in Denmark. They were identified from the files of the nationwide trial of the Danish Breast Cancer Co-operative group and the Danish Cancer Registry. The control group was an age-stratified random sample of 1,336 women from the general population. Data on risk factors were collected by self-administered (mailed) questionnaires. Significantly increased relative risks (RR) were associated with never being pregnant (RR = 1.47), an early terminated first pregnancy (RR = 1.43), and having a natural menopause after the age of 54 (RR = 1.67). Trends of decreasing risk were observed by increasing parity and age at menarche. These findings were independent of age at first full-term pregnancy which overall was not related to breast cancer risk, though a weak association appeared in women less than 50 years at diagnosis. The study confirmed that pregnancies must continue to term to offer protection against breast cancer. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/3166899/Risk_of_breast_cancer_in_relation_to_reproductive_factors_in_Denmark_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3166899/ DB - PRIME DP - Unbound Medicine ER -