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Preparation and evaluation of novel multi-channel orally disintegrating tablets.
Eur J Pharm Sci. 2020 Jan 15; 142:105108.EJ

Abstract

In this study, novel orally disintegrating tablets (ODTs) with multi-channel structure were designed to provide a rapid disintegration and subsequently drug dissolution. The ODTs were prepared using conventional wet compression through perforating channels with a special multi-channel mold. A modified sieve method was used in disintegration test as a quick screening tool during formulation evaluation. Moreover, physical properties, in vitro and in vivo disintegration time, dissolution rate and mouthfeel were also evaluated. The results demonstrated that developed multi-channel ODTs had good physical parameters, in vitro/in vivo correlation (IVIVC) of disintegration time and acceptable mouthfeel and dissolution. It also revealed that the presence of channels could accelerate the disintegration of ODTs because the channels could shorten the distance of water penetration and increased the specific surface area, resulting in a significant reduction in disintegration time. Above all, the introduction of novel multi-channel ODTs provided an alternative preparation method for ODTs and achieved good disintegration characteristics.

Authors+Show Affiliations

School of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, China; Affiliated Hospital of Hebei University, Baoding, China.Affiliated Hospital of Hebei University, Baoding, China.College of Medicine, Hebei University, Baoding, China; Affiliated Hospital of Hebei University, Baoding, China.College of Medicine, Hebei University, Baoding, China; Affiliated Hospital of Hebei University, Baoding, China.School of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, China.School of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, China.School of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, China; Affiliated Hospital of Hebei University, Baoding, China. Electronic address: gz1205@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31669391

Citation

Yu, Jiaojiao, et al. "Preparation and Evaluation of Novel Multi-channel Orally Disintegrating Tablets." European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, vol. 142, 2020, p. 105108.
Yu J, Shan X, Chen S, et al. Preparation and evaluation of novel multi-channel orally disintegrating tablets. Eur J Pharm Sci. 2020;142:105108.
Yu, J., Shan, X., Chen, S., Sun, X., Song, P., Zhao, R., & Hu, L. (2020). Preparation and evaluation of novel multi-channel orally disintegrating tablets. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 142, 105108. https://doi.org/10.1016/j.ejps.2019.105108
Yu J, et al. Preparation and Evaluation of Novel Multi-channel Orally Disintegrating Tablets. Eur J Pharm Sci. 2020 Jan 15;142:105108. PubMed PMID: 31669391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and evaluation of novel multi-channel orally disintegrating tablets. AU - Yu,Jiaojiao, AU - Shan,Xiaosong, AU - Chen,Shichao, AU - Sun,Xinli, AU - Song,Pengjin, AU - Zhao,Ruidong, AU - Hu,Liandong, Y1 - 2019/10/25/ PY - 2019/04/02/received PY - 2019/08/28/revised PY - 2019/10/13/accepted PY - 2019/11/2/pubmed PY - 2020/6/2/medline PY - 2019/11/1/entrez KW - Disintegration KW - Mouthfeel KW - Multi-channel KW - Orally disintegrating tablets SP - 105108 EP - 105108 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 142 N2 - In this study, novel orally disintegrating tablets (ODTs) with multi-channel structure were designed to provide a rapid disintegration and subsequently drug dissolution. The ODTs were prepared using conventional wet compression through perforating channels with a special multi-channel mold. A modified sieve method was used in disintegration test as a quick screening tool during formulation evaluation. Moreover, physical properties, in vitro and in vivo disintegration time, dissolution rate and mouthfeel were also evaluated. The results demonstrated that developed multi-channel ODTs had good physical parameters, in vitro/in vivo correlation (IVIVC) of disintegration time and acceptable mouthfeel and dissolution. It also revealed that the presence of channels could accelerate the disintegration of ODTs because the channels could shorten the distance of water penetration and increased the specific surface area, resulting in a significant reduction in disintegration time. Above all, the introduction of novel multi-channel ODTs provided an alternative preparation method for ODTs and achieved good disintegration characteristics. SN - 1879-0720 UR - https://www.unboundmedicine.com/medline/citation/31669391/Preparation_and_evaluation_of_novel_multi-channel_orally_disintegrating_tablets L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-0987(19)30381-1 DB - PRIME DP - Unbound Medicine ER -