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Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report.
Clin Psychopharmacol Neurosci. 2019 Nov 20; 17(4):559-563.CP

Abstract

Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails. In this report, a severe treatment-refractory schizophrenic patient who did not respond to clozapine even with ECT, but who recovered with asenapine monotherapy, is presented. Asenapine, considered a serotonin spectrum dopamine modulator, is a new atypical antipsychotic with unique pharmacological features that is used not only for schizophrenia, but also for bipolar disorder. The unique features of asenapine may be effective for some treatment-refractory schizophrenic patients.

Authors+Show Affiliations

Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon, Japan.Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon, Japan.Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon, Japan.Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon, Japan.Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon, Japan.Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31671497

Citation

Ochi, Shinichiro, et al. "Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined With Electroconvulsive Therapy: a Case Report." Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology, vol. 17, no. 4, 2019, pp. 559-563.
Ochi S, Inoue S, Yoshino Y, et al. Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. 2019;17(4):559-563.
Ochi, S., Inoue, S., Yoshino, Y., Shimizu, H., Iga, J. I., & Ueno, S. I. (2019). Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report. Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology, 17(4), 559-563. https://doi.org/10.9758/cpn.2019.17.4.559
Ochi S, et al. Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined With Electroconvulsive Therapy: a Case Report. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. 2019 Nov 20;17(4):559-563. PubMed PMID: 31671497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report. AU - Ochi,Shinichiro, AU - Inoue,Saori, AU - Yoshino,Yuta, AU - Shimizu,Hideaki, AU - Iga,Jun-Ichi, AU - Ueno,Shu-Ichi, PY - 2018/08/03/received PY - 2018/10/22/revised PY - 2018/11/19/accepted PY - 2019/11/2/entrez PY - 2019/11/2/pubmed PY - 2019/11/2/medline KW - Asenapine KW - Clozapine KW - Electroconvulsive therapy KW - Recurrence. KW - Suicide KW - Treatment-refractory schizophrenia SP - 559 EP - 563 JF - Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology VL - 17 IS - 4 N2 - Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails. In this report, a severe treatment-refractory schizophrenic patient who did not respond to clozapine even with ECT, but who recovered with asenapine monotherapy, is presented. Asenapine, considered a serotonin spectrum dopamine modulator, is a new atypical antipsychotic with unique pharmacological features that is used not only for schizophrenia, but also for bipolar disorder. The unique features of asenapine may be effective for some treatment-refractory schizophrenic patients. SN - 1738-1088 UR - https://www.unboundmedicine.com/medline/citation/31671497/Efficacy_of_Asenapine_in_Schizophrenia_Resistant_to_Clozapine_Combined_with_Electroconvulsive_Therapy:_A_Case_Report_ L2 - http://www.cpn.or.kr/journal/journal_view.html?year=2019&vol=17&num=4&page=559 DB - PRIME DP - Unbound Medicine ER -
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