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Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers.
Int J Mol Sci 2019; 20(21)IJ

Abstract

The homeostasis of the central nervous system (CNS) is ensured by the endothelial, epithelial, mesothelial and glial brain barriers, which strictly control the passage of molecules, solutes and immune cells. While the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB) have been extensively investigated, less is known about the epithelial and mesothelial arachnoid barrier and the glia limitans. Here, we summarize current knowledge of the cellular composition of the brain barriers with a specific focus on describing the molecular constituents of their junctional complexes. We propose that the brain barriers maintain CNS immune privilege by dividing the CNS into compartments that differ with regard to their role in immune surveillance of the CNS. We close by providing a brief overview on experimental tools allowing for reliable in vivo visualization of the brain barriers and their junctional complexes and thus the respective CNS compartments.

Authors+Show Affiliations

Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland. mariana.dias@tki.unibe.ch.Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland. josephine.mapunda@tki.unibe.ch.Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland. mykhailo.vladymyrov@tki.unibe.ch.Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland. bengel@tki.unibe.ch.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31671721

Citation

Castro Dias, Mariana, et al. "Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers." International Journal of Molecular Sciences, vol. 20, no. 21, 2019.
Castro Dias M, Mapunda JA, Vladymyrov M, et al. Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. Int J Mol Sci. 2019;20(21).
Castro Dias, M., Mapunda, J. A., Vladymyrov, M., & Engelhardt, B. (2019). Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. International Journal of Molecular Sciences, 20(21), doi:10.3390/ijms20215372.
Castro Dias M, et al. Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. Int J Mol Sci. 2019 Oct 29;20(21) PubMed PMID: 31671721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers. AU - Castro Dias,Mariana, AU - Mapunda,Josephine A, AU - Vladymyrov,Mykhailo, AU - Engelhardt,Britta, Y1 - 2019/10/29/ PY - 2019/10/14/received PY - 2019/10/25/revised PY - 2019/10/26/accepted PY - 2019/11/2/entrez PY - 2019/11/2/pubmed PY - 2019/11/2/medline KW - adherens junctions KW - arachnoid barrier KW - blood-brain barrier KW - blood-cerebrospinal fluid barrier KW - brain barriers KW - glia limitans KW - neurovascular unit KW - tight junctions JF - International journal of molecular sciences JO - Int J Mol Sci VL - 20 IS - 21 N2 - The homeostasis of the central nervous system (CNS) is ensured by the endothelial, epithelial, mesothelial and glial brain barriers, which strictly control the passage of molecules, solutes and immune cells. While the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB) have been extensively investigated, less is known about the epithelial and mesothelial arachnoid barrier and the glia limitans. Here, we summarize current knowledge of the cellular composition of the brain barriers with a specific focus on describing the molecular constituents of their junctional complexes. We propose that the brain barriers maintain CNS immune privilege by dividing the CNS into compartments that differ with regard to their role in immune surveillance of the CNS. We close by providing a brief overview on experimental tools allowing for reliable in vivo visualization of the brain barriers and their junctional complexes and thus the respective CNS compartments. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/31671721/Structure_and_Junctional_Complexes_of_Endothelial,_Epithelial_and_Glial_Brain_Barriers L2 - http://www.mdpi.com/resolver?pii=ijms20215372 DB - PRIME DP - Unbound Medicine ER -