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The toxicity of silver nanomaterials (NM 300K) is reduced when combined with N-Acetylcysteine: Hazard assessment on Enchytraeus crypticus.
Environ Pollut. 2020 Jan; 256:113484.EP

Abstract

The widespread production and use of silver nanomaterials (AgNMs) in consumer and medical products have been raising environmental concerns. Once in the environment, the soil is one of the major sinks of AgNMs due to e.g. sewage sludge applications, and invertebrates are directly exposed. In this study, we investigate the potential of N-acetylcysteine (NAC) to reduce the toxic effects of Ag NM300 K (and AgNO3) on the soil invertebrate Enchytraeus crypticus. Ag NM300 K induces mortality, reproduction impairment, and avoidance. The addition of NAC to the soil showed a remarkable reduction in the toxicity of Ag, indicating that NAC can act as a detoxifying agent for terrestrial organisms exposed to Ag materials. That the reduction in toxicity likely is caused by thiol groups, was confirmed by GSH and GSSH studies. Identifying the mechanisms and hence alternatives that allow the recovery of contaminated soils is an important mitigation measure to promote environmental safety and reduce the associated risks to human health. Further, it may inform on strategies to implement in safe-by-design industry development.

Authors+Show Affiliations

Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, 13083-970, Brazil; Department of Biology, CESAM, University of Aveiro, Aveiro, 3810-193, Portugal.Department of Biology, CESAM, University of Aveiro, Aveiro, 3810-193, Portugal.Department of Bioscience, Aarhus University, Silkeborg, DK-8600, Denmark.Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, 13083-970, Brazil.Department of Biology, CESAM, University of Aveiro, Aveiro, 3810-193, Portugal. Electronic address: mjamorim@ua.pt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31677872

Citation

Mendonça, Monique C P., et al. "The Toxicity of Silver Nanomaterials (NM 300K) Is Reduced when Combined With N-Acetylcysteine: Hazard Assessment On Enchytraeus Crypticus." Environmental Pollution (Barking, Essex : 1987), vol. 256, 2020, p. 113484.
Mendonça MCP, Rodrigues NP, Scott-Fordsmand JJ, et al. The toxicity of silver nanomaterials (NM 300K) is reduced when combined with N-Acetylcysteine: Hazard assessment on Enchytraeus crypticus. Environ Pollut. 2020;256:113484.
Mendonça, M. C. P., Rodrigues, N. P., Scott-Fordsmand, J. J., Jesus, M. B., & Amorim, M. J. B. (2020). The toxicity of silver nanomaterials (NM 300K) is reduced when combined with N-Acetylcysteine: Hazard assessment on Enchytraeus crypticus. Environmental Pollution (Barking, Essex : 1987), 256, 113484. https://doi.org/10.1016/j.envpol.2019.113484
Mendonça MCP, et al. The Toxicity of Silver Nanomaterials (NM 300K) Is Reduced when Combined With N-Acetylcysteine: Hazard Assessment On Enchytraeus Crypticus. Environ Pollut. 2020;256:113484. PubMed PMID: 31677872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The toxicity of silver nanomaterials (NM 300K) is reduced when combined with N-Acetylcysteine: Hazard assessment on Enchytraeus crypticus. AU - Mendonça,Monique C P, AU - Rodrigues,Natália P, AU - Scott-Fordsmand,Janeck J, AU - Jesus,Marcelo Bispo de, AU - Amorim,Mónica J B, Y1 - 2019/10/24/ PY - 2019/09/06/received PY - 2019/10/07/revised PY - 2019/10/23/accepted PY - 2019/11/5/pubmed PY - 2020/2/12/medline PY - 2019/11/4/entrez KW - Avoidance behaviour KW - Invertebrates KW - Nanomaterials KW - Safe-by-design KW - Thiol compounds SP - 113484 EP - 113484 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 256 N2 - The widespread production and use of silver nanomaterials (AgNMs) in consumer and medical products have been raising environmental concerns. Once in the environment, the soil is one of the major sinks of AgNMs due to e.g. sewage sludge applications, and invertebrates are directly exposed. In this study, we investigate the potential of N-acetylcysteine (NAC) to reduce the toxic effects of Ag NM300 K (and AgNO3) on the soil invertebrate Enchytraeus crypticus. Ag NM300 K induces mortality, reproduction impairment, and avoidance. The addition of NAC to the soil showed a remarkable reduction in the toxicity of Ag, indicating that NAC can act as a detoxifying agent for terrestrial organisms exposed to Ag materials. That the reduction in toxicity likely is caused by thiol groups, was confirmed by GSH and GSSH studies. Identifying the mechanisms and hence alternatives that allow the recovery of contaminated soils is an important mitigation measure to promote environmental safety and reduce the associated risks to human health. Further, it may inform on strategies to implement in safe-by-design industry development. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/31677872/The_toxicity_of_silver_nanomaterials__NM_300K__is_reduced_when_combined_with_N_Acetylcysteine:_Hazard_assessment_on_Enchytraeus_crypticus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(19)35094-8 DB - PRIME DP - Unbound Medicine ER -