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Cyclodextrin-based sorbents for solid phase extraction.
J Chromatogr A. 2020 Jan 04; 1609:460654.JC

Abstract

Cyclodestrins (CDs) are cyclic oligosaccharides well-known for their ability to form host-guest inclusion complexes with properly sized compounds. They have been used for decades as chiral selectors as well as drug delivery systems within the frameworks of separation science and pharmaceutical science. More recently, their use has been extended to the field of extractive science under the stimulus of additional advantageous characteristics, such as low-price, negligible environmental impact, non-toxicity, as arising from the fact that natural CDs are starch degradation products. To abate their solubility in water and generate novel sorbents for solid phase extraction, the following approaches have been employed: (i) immobilization onto inert materials (silica, attapulgite, etc.); (ii) immobilization onto nanomaterials (magnetic nanoparticles, titanium oxide, carbon nanotubes, graphene oxide, etc.); (iii) polymerisation with specific cross-linkers to form the so-called CD-based nanosponges. Particularly promising are these last ones for their selectivity, mesoporous structure, insolubility in aqueous media and good dispersibility. This review offers a concise overview on the state of art and future prospects of CDs in this important sector of the analytical chemistry, offering a critical perspective of the most significant applications.

Authors+Show Affiliations

Department of Chemistry, Faculty of Mathematical, Physical and Natural Sciences, "Sapienza" University of Rome, P.le A. Moro n° 5, 00185 Rome, Italy. Electronic address: alessandra.gentili@uniroma1.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31679713

Citation

Gentili, Alessandra. "Cyclodextrin-based Sorbents for Solid Phase Extraction." Journal of Chromatography. A, vol. 1609, 2020, p. 460654.
Gentili A. Cyclodextrin-based sorbents for solid phase extraction. J Chromatogr A. 2020;1609:460654.
Gentili, A. (2020). Cyclodextrin-based sorbents for solid phase extraction. Journal of Chromatography. A, 1609, 460654. https://doi.org/10.1016/j.chroma.2019.460654
Gentili A. Cyclodextrin-based Sorbents for Solid Phase Extraction. J Chromatogr A. 2020 Jan 4;1609:460654. PubMed PMID: 31679713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyclodextrin-based sorbents for solid phase extraction. A1 - Gentili,Alessandra, Y1 - 2019/10/24/ PY - 2019/09/21/received PY - 2019/10/20/revised PY - 2019/10/23/accepted PY - 2019/11/5/pubmed PY - 2020/2/28/medline PY - 2019/11/5/entrez KW - Cyclodextrin polymers KW - Cyclodextrin-based composite sorbents KW - Cyclodextrin-based nanosponges KW - Cyclodextrins KW - Green solvents KW - Solid phase extraction SP - 460654 EP - 460654 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1609 N2 - Cyclodestrins (CDs) are cyclic oligosaccharides well-known for their ability to form host-guest inclusion complexes with properly sized compounds. They have been used for decades as chiral selectors as well as drug delivery systems within the frameworks of separation science and pharmaceutical science. More recently, their use has been extended to the field of extractive science under the stimulus of additional advantageous characteristics, such as low-price, negligible environmental impact, non-toxicity, as arising from the fact that natural CDs are starch degradation products. To abate their solubility in water and generate novel sorbents for solid phase extraction, the following approaches have been employed: (i) immobilization onto inert materials (silica, attapulgite, etc.); (ii) immobilization onto nanomaterials (magnetic nanoparticles, titanium oxide, carbon nanotubes, graphene oxide, etc.); (iii) polymerisation with specific cross-linkers to form the so-called CD-based nanosponges. Particularly promising are these last ones for their selectivity, mesoporous structure, insolubility in aqueous media and good dispersibility. This review offers a concise overview on the state of art and future prospects of CDs in this important sector of the analytical chemistry, offering a critical perspective of the most significant applications. SN - 1873-3778 UR - https://www.unboundmedicine.com/medline/citation/31679713/Cyclodextrin-based_sorbents_for_solid_phase_extraction L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(19)31076-3 DB - PRIME DP - Unbound Medicine ER -