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Antifungal potency of Nigella sativa seeds extract against Rhizopus stolonifer and their effect of immunomodulatory against aflatoxin-fed mice.
Pak J Pharm Sci. 2019 Jul; 32(4(Supplementary)):1849-1854.PJ

Abstract

The present study describes the antifungal potency of Nigella sativa seeds extract and the effect of immunomodulatory of N. sativa against aflatoxin- fed mice. Disc diffusion method was used for antifungal efficacy of aqueous extract of N. sativa. In animal experiments, lymphoid cell count, total and differential counts of PEC, the phagocytic activity of PEC and detection of the plaque-forming were determined. E-rosette-forming cells (RFC), T-cell mitogenesis assay cells, ALT and AST were detected. The aqueous extract of N. sativa (50%) exhibited high inhibition zone with most of isolates of R. stolonifera.The results indicated that treatment of mice by using N. sativa showed marked rise in the number of cells from thymus and PLN with dose 0.50 g and absolute number and comparative ratio of macrophages (P < 0.01) with the doses 0.40 and 0.50 g. There is gradually rise in the scavenger activity of PEC with the dose 0.50 g at 60 min. Serum level of ALT was markedly reduced with dose 0.50 g as compared with a control group. These results indicated that N. sativa is promising modifier of biological response.

Authors+Show Affiliations

Biology Department, College of Science, Girls branch, King Khalid University, Abha. KSA.Biology Department, College of Science, Girls branch, King Khalid University, Abha. KSA.Biology Department, College of Science, Girls branch, King Khalid University, Abha. KSA.Plant and microbiology Department, College of Science, Girls Branch, Al Azhar University, Cairo, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31680082

Citation

Othman, Gehan Ahmed, et al. "Antifungal Potency of Nigella Sativa Seeds Extract Against Rhizopus Stolonifer and Their Effect of Immunomodulatory Against Aflatoxin-fed Mice." Pakistan Journal of Pharmaceutical Sciences, vol. 32, no. 4(Supplementary), 2019, pp. 1849-1854.
Othman GA, Alghamdi HA, Ahmed DAEM, et al. Antifungal potency of Nigella sativa seeds extract against Rhizopus stolonifer and their effect of immunomodulatory against aflatoxin-fed mice. Pak J Pharm Sci. 2019;32(4(Supplementary)):1849-1854.
Othman, G. A., Alghamdi, H. A., Ahmed, D. A. E. M., & Radwan, A. M. (2019). Antifungal potency of Nigella sativa seeds extract against Rhizopus stolonifer and their effect of immunomodulatory against aflatoxin-fed mice. Pakistan Journal of Pharmaceutical Sciences, 32(4(Supplementary)), 1849-1854.
Othman GA, et al. Antifungal Potency of Nigella Sativa Seeds Extract Against Rhizopus Stolonifer and Their Effect of Immunomodulatory Against Aflatoxin-fed Mice. Pak J Pharm Sci. 2019;32(4(Supplementary)):1849-1854. PubMed PMID: 31680082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal potency of Nigella sativa seeds extract against Rhizopus stolonifer and their effect of immunomodulatory against aflatoxin-fed mice. AU - Othman,Gehan Ahmed, AU - Alghamdi,Huda A, AU - Ahmed,Dalia Abd El Moneim, AU - Radwan,Asmaa Mahmoud, PY - 2019/11/5/entrez PY - 2019/11/5/pubmed PY - 2020/3/24/medline SP - 1849 EP - 1854 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 32 IS - 4(Supplementary) N2 - The present study describes the antifungal potency of Nigella sativa seeds extract and the effect of immunomodulatory of N. sativa against aflatoxin- fed mice. Disc diffusion method was used for antifungal efficacy of aqueous extract of N. sativa. In animal experiments, lymphoid cell count, total and differential counts of PEC, the phagocytic activity of PEC and detection of the plaque-forming were determined. E-rosette-forming cells (RFC), T-cell mitogenesis assay cells, ALT and AST were detected. The aqueous extract of N. sativa (50%) exhibited high inhibition zone with most of isolates of R. stolonifera.The results indicated that treatment of mice by using N. sativa showed marked rise in the number of cells from thymus and PLN with dose 0.50 g and absolute number and comparative ratio of macrophages (P < 0.01) with the doses 0.40 and 0.50 g. There is gradually rise in the scavenger activity of PEC with the dose 0.50 g at 60 min. Serum level of ALT was markedly reduced with dose 0.50 g as compared with a control group. These results indicated that N. sativa is promising modifier of biological response. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/31680082/Antifungal_potency_of_Nigella_sativa_seeds_extract_against_Rhizopus_stolonifer_and_their_effect_of_immunomodulatory_against_aflatoxin_fed_mice_ DB - PRIME DP - Unbound Medicine ER -