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Four new flavonol glycosides from the leaves of Ginkgo biloba.
Nat Prod Res. 2021 Aug; 35(15):2520-2525.NP

Abstract

Four new flavonol glycosides, 5, 7, 5'-trihydroxy-3', 4'-dimethoxyflavonol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (1), quercetin 3-O-(6-trans-feruloyl)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (2), kaempferol 3-O-(6-trans-caffeoyl)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (3), myricetin 3-O-(6-trans-p-coumaroyl)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (4), together with nine known flavonoids and two known lignans, were isolated from the leaves of Ginkgo biloba. Their structures were determined by extensive spectroscopic analyses. Their cardioprotective effects against H2O2-induced apoptosis in H9c2 cells were also evaluated. The flavonol glycosides had stronger activity than the acylated flavonol glycosides at the concentration of 50 µM.

Authors+Show Affiliations

Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, People's Republic of China. State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People's Republic of China. Modern Chinese Medicine Innovation Cluster and Digital Pharmaceutical Technology Platform, Lianyungang, People's Republic of China.Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, People's Republic of China. State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People's Republic of China. Modern Chinese Medicine Innovation Cluster and Digital Pharmaceutical Technology Platform, Lianyungang, People's Republic of China.Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, People's Republic of China. State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People's Republic of China. Modern Chinese Medicine Innovation Cluster and Digital Pharmaceutical Technology Platform, Lianyungang, People's Republic of China.Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, People's Republic of China. State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People's Republic of China. Modern Chinese Medicine Innovation Cluster and Digital Pharmaceutical Technology Platform, Lianyungang, People's Republic of China.Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, People's Republic of China. State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People's Republic of China. Modern Chinese Medicine Innovation Cluster and Digital Pharmaceutical Technology Platform, Lianyungang, People's Republic of China.Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, People's Republic of China. State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People's Republic of China. Modern Chinese Medicine Innovation Cluster and Digital Pharmaceutical Technology Platform, Lianyungang, People's Republic of China.Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, People's Republic of China. State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People's Republic of China. Modern Chinese Medicine Innovation Cluster and Digital Pharmaceutical Technology Platform, Lianyungang, People's Republic of China.Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, People's Republic of China. State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People's Republic of China. Modern Chinese Medicine Innovation Cluster and Digital Pharmaceutical Technology Platform, Lianyungang, People's Republic of China.Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, People's Republic of China. State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People's Republic of China. Modern Chinese Medicine Innovation Cluster and Digital Pharmaceutical Technology Platform, Lianyungang, People's Republic of China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31680566

Citation

Wang, Yongxiang, et al. "Four New Flavonol Glycosides From the Leaves of Ginkgo Biloba." Natural Product Research, vol. 35, no. 15, 2021, pp. 2520-2525.
Wang Y, Xie X, Liu L, et al. Four new flavonol glycosides from the leaves of Ginkgo biloba. Nat Prod Res. 2021;35(15):2520-2525.
Wang, Y., Xie, X., Liu, L., Zhang, H., Ni, F., Wen, J., Wu, Y., Wang, Z., & Xiao, W. (2021). Four new flavonol glycosides from the leaves of Ginkgo biloba. Natural Product Research, 35(15), 2520-2525. https://doi.org/10.1080/14786419.2019.1684282
Wang Y, et al. Four New Flavonol Glycosides From the Leaves of Ginkgo Biloba. Nat Prod Res. 2021;35(15):2520-2525. PubMed PMID: 31680566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Four new flavonol glycosides from the leaves of Ginkgo biloba. AU - Wang,Yongxiang, AU - Xie,Xue, AU - Liu,Lina, AU - Zhang,Hongda, AU - Ni,Fuyong, AU - Wen,Jianhui, AU - Wu,Yun, AU - Wang,Zhenzhong, AU - Xiao,Wei, Y1 - 2019/11/04/ PY - 2019/11/5/pubmed PY - 2021/10/7/medline PY - 2019/11/5/entrez KW - Ginkgo biloba KW - acylated flavonol glycoside KW - cardioprotective activity SP - 2520 EP - 2525 JF - Natural product research JO - Nat Prod Res VL - 35 IS - 15 N2 - Four new flavonol glycosides, 5, 7, 5'-trihydroxy-3', 4'-dimethoxyflavonol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (1), quercetin 3-O-(6-trans-feruloyl)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (2), kaempferol 3-O-(6-trans-caffeoyl)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (3), myricetin 3-O-(6-trans-p-coumaroyl)-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (4), together with nine known flavonoids and two known lignans, were isolated from the leaves of Ginkgo biloba. Their structures were determined by extensive spectroscopic analyses. Their cardioprotective effects against H2O2-induced apoptosis in H9c2 cells were also evaluated. The flavonol glycosides had stronger activity than the acylated flavonol glycosides at the concentration of 50 µM. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/31680566/Four_new_flavonol_glycosides_from_the_leaves_of_Ginkgo_biloba_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1684282 DB - PRIME DP - Unbound Medicine ER -