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GEO-PGS composite shows synergistic and complementary effect on Escherichia coli and improvement of intestinal dysfunction.
Food Chem Toxicol. 2020 Jan; 135:110936.FC

Abstract

Palygorskite (PGS) is a kind of clay minerals with the property of absorbent capacity, and ginger essential oil (GEO) is a kind of natural antibacterial substances. In the present study PGS was used as carrier of GEO, and thus, a kind of new anti-bacterial composite GEO-PGS has been obtained. Characterization, inhibitory effect of GEO-PGS on Escherichia coli (E. coli) and its function of improvement of intestinal health would be investigated. Results showed that characterization analysis of GEO-PGS (FTIR, TG-DSC, BET, Zeta potential, specific surface area, total pore volume and size, TEM observation) demonstrated combination of GEO and PGS, and GEO was absorbed on the surface of PGS, partially filled the micropores of PGS. GEO-PGS had obvious inhibitory effect on E.coli, in combination of the antibacterial activity of GEO and bacteria-absorbed capability of PGS. GEO-PGS also had ameliorating effect on enteritis and intestinal dysfunction in vivo, which might be related to the inhibition of gene expression of inflammatory cytokines (TLR2, IL-6, TNFα, and IL-8). In conclusion, the novel composite GEO-PGS has the potential usage as functional component having effect of improving intestinal health.

Authors+Show Affiliations

College of Food Science and Engineering / Collaborative Innovation Center for Modern Grain Circulation and Safety / Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing, 210023, China.School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.College of Food Science and Engineering / Collaborative Innovation Center for Modern Grain Circulation and Safety / Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing, 210023, China.College of Food Science and Engineering / Collaborative Innovation Center for Modern Grain Circulation and Safety / Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing, 210023, China.College of Food Science and Engineering / Collaborative Innovation Center for Modern Grain Circulation and Safety / Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing, 210023, China. Electronic address: leihong56@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31682933

Citation

Xu, Na, et al. "GEO-PGS Composite Shows Synergistic and Complementary Effect On Escherichia Coli and Improvement of Intestinal Dysfunction." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 135, 2020, p. 110936.
Xu N, Zhou R, Jiang Q, et al. GEO-PGS composite shows synergistic and complementary effect on Escherichia coli and improvement of intestinal dysfunction. Food Chem Toxicol. 2020;135:110936.
Xu, N., Zhou, R., Jiang, Q., Kong, L., & Lei, H. (2020). GEO-PGS composite shows synergistic and complementary effect on Escherichia coli and improvement of intestinal dysfunction. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 135, 110936. https://doi.org/10.1016/j.fct.2019.110936
Xu N, et al. GEO-PGS Composite Shows Synergistic and Complementary Effect On Escherichia Coli and Improvement of Intestinal Dysfunction. Food Chem Toxicol. 2020;135:110936. PubMed PMID: 31682933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - GEO-PGS composite shows synergistic and complementary effect on Escherichia coli and improvement of intestinal dysfunction. AU - Xu,Na, AU - Zhou,Renjie, AU - Jiang,Qian, AU - Kong,Lingyan, AU - Lei,Hong, Y1 - 2019/11/02/ PY - 2019/09/17/received PY - 2019/10/24/revised PY - 2019/10/29/accepted PY - 2019/11/5/pubmed PY - 2020/1/28/medline PY - 2019/11/5/entrez KW - Anti-bacterial effect KW - Characterization KW - Escherichia coli KW - Ginger essential oil-Palygorskite composite KW - Intestinal health SP - 110936 EP - 110936 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 135 N2 - Palygorskite (PGS) is a kind of clay minerals with the property of absorbent capacity, and ginger essential oil (GEO) is a kind of natural antibacterial substances. In the present study PGS was used as carrier of GEO, and thus, a kind of new anti-bacterial composite GEO-PGS has been obtained. Characterization, inhibitory effect of GEO-PGS on Escherichia coli (E. coli) and its function of improvement of intestinal health would be investigated. Results showed that characterization analysis of GEO-PGS (FTIR, TG-DSC, BET, Zeta potential, specific surface area, total pore volume and size, TEM observation) demonstrated combination of GEO and PGS, and GEO was absorbed on the surface of PGS, partially filled the micropores of PGS. GEO-PGS had obvious inhibitory effect on E.coli, in combination of the antibacterial activity of GEO and bacteria-absorbed capability of PGS. GEO-PGS also had ameliorating effect on enteritis and intestinal dysfunction in vivo, which might be related to the inhibition of gene expression of inflammatory cytokines (TLR2, IL-6, TNFα, and IL-8). In conclusion, the novel composite GEO-PGS has the potential usage as functional component having effect of improving intestinal health. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/31682933/GEO-PGS_composite_shows_synergistic_and_complementary_effect_on_Escherichia_coli_and_improvement_of_intestinal_dysfunction L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(19)30726-4 DB - PRIME DP - Unbound Medicine ER -