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An evaluation of measles serodiagnosis during an outbreak in a vaccinated community.
Clin Invest Med. 1988 Aug; 11(4):304-9.CI

Abstract

During an epidemic of measles in a vaccinated community, five serodiagnostic tests were performed on 67 persons on whom clinical and epidemiological data were available. The test found most suitable for a rapid diagnosis of measles infection was an Enzyme Linked Immuno Sorbent Assay for the detection of specific IgM antibodies. Only one false negative IgM was recorded. In a group of 45 persons who fulfilled the clinical definition of measles, specific IgM antibodies were detected in the acute phase serum of only 30 (66.6%), of whom 17 were vaccinated. When the convalescent sera were tested, specific IgM antibodies were detected in 25 of the 28 (89.2%) vaccinated, and in 17 of the 17 (100%) non vaccinated clinical cases. A convalescent blood should be tested in persons with a rash illness and no IgM antibodies in the acute phase serum. There were individual variations in the time of appearance of IgM. On the day of onset of rash, IgM antibodies were detected in 7 of the 12 (58.3%). A history of prior vaccination is not always associated with immunity nor with the presence of specific antibodies.

Authors+Show Affiliations

Cadham Provincial Laboratory, Winnipeg, Manitoba.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3168353

Citation

Sekla, L, et al. "An Evaluation of Measles Serodiagnosis During an Outbreak in a Vaccinated Community." Clinical and Investigative Medicine. Medecine Clinique Et Experimentale, vol. 11, no. 4, 1988, pp. 304-9.
Sekla L, Stackiw W, Eibisch G, et al. An evaluation of measles serodiagnosis during an outbreak in a vaccinated community. Clin Invest Med. 1988;11(4):304-9.
Sekla, L., Stackiw, W., Eibisch, G., & Johnson, I. (1988). An evaluation of measles serodiagnosis during an outbreak in a vaccinated community. Clinical and Investigative Medicine. Medecine Clinique Et Experimentale, 11(4), 304-9.
Sekla L, et al. An Evaluation of Measles Serodiagnosis During an Outbreak in a Vaccinated Community. Clin Invest Med. 1988;11(4):304-9. PubMed PMID: 3168353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An evaluation of measles serodiagnosis during an outbreak in a vaccinated community. AU - Sekla,L, AU - Stackiw,W, AU - Eibisch,G, AU - Johnson,I, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 304 EP - 9 JF - Clinical and investigative medicine. Medecine clinique et experimentale JO - Clin Invest Med VL - 11 IS - 4 N2 - During an epidemic of measles in a vaccinated community, five serodiagnostic tests were performed on 67 persons on whom clinical and epidemiological data were available. The test found most suitable for a rapid diagnosis of measles infection was an Enzyme Linked Immuno Sorbent Assay for the detection of specific IgM antibodies. Only one false negative IgM was recorded. In a group of 45 persons who fulfilled the clinical definition of measles, specific IgM antibodies were detected in the acute phase serum of only 30 (66.6%), of whom 17 were vaccinated. When the convalescent sera were tested, specific IgM antibodies were detected in 25 of the 28 (89.2%) vaccinated, and in 17 of the 17 (100%) non vaccinated clinical cases. A convalescent blood should be tested in persons with a rash illness and no IgM antibodies in the acute phase serum. There were individual variations in the time of appearance of IgM. On the day of onset of rash, IgM antibodies were detected in 7 of the 12 (58.3%). A history of prior vaccination is not always associated with immunity nor with the presence of specific antibodies. SN - 0147-958X UR - https://www.unboundmedicine.com/medline/citation/3168353/An_evaluation_of_measles_serodiagnosis_during_an_outbreak_in_a_vaccinated_community_ DB - PRIME DP - Unbound Medicine ER -