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Pleiotropic Effects of Modified Citrus Pectin.
Nutrients. 2019 Nov 01; 11(11)N

Abstract

Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models. Regarding cancer, MCP modulates several rate-limiting steps of the metastatic cascade. MCP can also affect cancer cell resistance to chemotherapy. Regarding fibrotic diseases, MCP modulates many of the steps involved in the pathogenesis of aortic stenosis. MCP also reduces fibrosis to the kidney, liver, and adipose tissue. Other benefits of MCP include detoxification and improved immune function. This review summarizes the pleiotropic effects of MCP.

Authors+Show Affiliations

Amitabha Medical Clinic and Healing Center, 398 Tesconi Ct, Santa Rosa, CA 95401, USA. isaac.eliaz@gmail.com.Departments of Oncology and Pathology, School of Medicine, Wayne State University and Barbara Ann Karmanos Cancer Institute, 4100 John R St, Detroit, MI 48201, USA. raza@karmanos.org.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31683865

Citation

Eliaz, Isaac, and Avraham Raz. "Pleiotropic Effects of Modified Citrus Pectin." Nutrients, vol. 11, no. 11, 2019.
Eliaz I, Raz A. Pleiotropic Effects of Modified Citrus Pectin. Nutrients. 2019;11(11).
Eliaz, I., & Raz, A. (2019). Pleiotropic Effects of Modified Citrus Pectin. Nutrients, 11(11). https://doi.org/10.3390/nu11112619
Eliaz I, Raz A. Pleiotropic Effects of Modified Citrus Pectin. Nutrients. 2019 Nov 1;11(11) PubMed PMID: 31683865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pleiotropic Effects of Modified Citrus Pectin. AU - Eliaz,Isaac, AU - Raz,Avraham, Y1 - 2019/11/01/ PY - 2019/09/24/received PY - 2019/10/24/revised PY - 2019/10/28/accepted PY - 2019/11/6/entrez PY - 2019/11/7/pubmed PY - 2020/4/3/medline KW - cancer KW - cardiovascular KW - fibrosis KW - galectin KW - inflammation KW - pectasol JF - Nutrients JO - Nutrients VL - 11 IS - 11 N2 - Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models. Regarding cancer, MCP modulates several rate-limiting steps of the metastatic cascade. MCP can also affect cancer cell resistance to chemotherapy. Regarding fibrotic diseases, MCP modulates many of the steps involved in the pathogenesis of aortic stenosis. MCP also reduces fibrosis to the kidney, liver, and adipose tissue. Other benefits of MCP include detoxification and improved immune function. This review summarizes the pleiotropic effects of MCP. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/31683865/Pleiotropic_Effects_of_Modified_Citrus_Pectin_ L2 - https://www.mdpi.com/resolver?pii=nu11112619 DB - PRIME DP - Unbound Medicine ER -