Citation
Jiang, Guang-Bin, et al. "New Ruthenium Polypyridyl Complexes Functionalized With Fluorine Atom or Furan: Synthesis, DNA-binding, Cytotoxicity and Antitumor Mechanism Studies." Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, vol. 227, 2020, p. 117534.
Jiang GB, Zhang WY, He M, et al. New ruthenium polypyridyl complexes functionalized with fluorine atom or furan: Synthesis, DNA-binding, cytotoxicity and antitumor mechanism studies. Spectrochim Acta A Mol Biomol Spectrosc. 2020;227:117534.
Jiang, G. B., Zhang, W. Y., He, M., Gu, Y. Y., Bai, L., Wang, Y. J., Yi, Q. Y., & Du, F. (2020). New ruthenium polypyridyl complexes functionalized with fluorine atom or furan: Synthesis, DNA-binding, cytotoxicity and antitumor mechanism studies. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 227, 117534. https://doi.org/10.1016/j.saa.2019.117534
Jiang GB, et al. New Ruthenium Polypyridyl Complexes Functionalized With Fluorine Atom or Furan: Synthesis, DNA-binding, Cytotoxicity and Antitumor Mechanism Studies. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Feb 15;227:117534. PubMed PMID: 31685424.
TY - JOUR
T1 - New ruthenium polypyridyl complexes functionalized with fluorine atom or furan: Synthesis, DNA-binding, cytotoxicity and antitumor mechanism studies.
AU - Jiang,Guang-Bin,
AU - Zhang,Wen-Yao,
AU - He,Miao,
AU - Gu,Yi-Ying,
AU - Bai,Lan,
AU - Wang,Yang-Jie,
AU - Yi,Qiao-Yan,
AU - Du,Fan,
Y1 - 2019/10/25/
PY - 2019/07/24/received
PY - 2019/08/27/revised
PY - 2019/09/13/accepted
PY - 2019/11/7/pubmed
PY - 2019/11/7/medline
PY - 2019/11/6/entrez
KW - Antitumor
KW - Cell cycle arrest
KW - DNA binding
KW - Reactive oxygen species
KW - Ru(II) polypyridyl complex
SP - 117534
EP - 117534
JF - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
JO - Spectrochim Acta A Mol Biomol Spectrosc
VL - 227
N2 - Two novel ruthenium(II) polypyridyl complexes, namely, [Ru(dmp)2(CAPIP)](ClO4)2 (Ru(II)-1) and [Ru(dmp)2(CFPIP)](ClO4)2 (Ru(II)-2), which respectively contain (E)-2-(2-(furan-2-yl)vinyl)-1H-imidazo[4,5-f][1,10]phen-anthroline (CAPIP) and (E)-2-(4-fluorostyryl)-1H-imidazo[4,5-f][1,10]phenanthroline. (CFPIP), were first designed and characterized (dmp = 2,9-dimethyl-1,10-phenanthroline). DNA binding experiments indicated that Ru(II) complexes interact with CT DNA through intercalative mode. In addition, the complexes Ru(II)-1 and Ru(II)-2, showed remarkable cell cytotoxicity, giving the respective IC50 values of 4.1 ± 1.4 μM and 6.1 ± 1.4 μM on the A549 cancer cells. These values indicated higher activity than CAPIP, CFPIP, cisplatin (8.2 ± 1.4 μM) and other corresponding Ru(II) polypyridyl complexes. Furthermore, the Ru(II) complexes could arrive the cytoplasm through the cell membrane and accumulate in the mitochondria. Significantly, complexes Ru(II)-1 and Ru(II)-2 induced A549 cells apoptosis was mediated by increase of ROS levels and dysfunction of mitochondria, and resulted in cell cycle arrest and increased anti-migration activity on A549 cells. Overall, these results indicated that complexes Ru(II)-1 and Ru(II)-2 could be suitable candidates for further investigation as a chemotherapeutic agent in the treatment of tumors.
SN - 1873-3557
UR - https://www.unboundmedicine.com/medline/citation/31685424/New_ruthenium_polypyridyl_complexes_functionalized_with_fluorine_atom_or_furan:_Synthesis_DNA_binding_cytotoxicity_and_antitumor_mechanism_studies_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-1425(19)30924-2
DB - PRIME
DP - Unbound Medicine
ER -
