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Vitamin D and Calcium Supplements: Helpful, Harmful, or Neutral for Cardiovascular Risk?
Methodist Debakey Cardiovasc J 2019 Jul-Sep; 15(3):207-213MD

Abstract

Vitamin D has traditionally been known as the "bone vitamin". However, a large body of observational data has also linked low concentrations of serum 25-hydroxyvitamin D (25[OH]D), the primary storage form of vitamin D, to an increased risk of incident cardiovascular disease (CVD) and mortality, garnering public excitement about the purported nonskeletal benefits of vitamin D. Despite this, more recent meta-analyses and randomized clinical trials have failed to find a beneficial effect of vitamin D supplements on CVD and cancer outcomes. These findings, along with the lack of consensus on optimal serum 25(OH)D concentrations, have dampened some of the initial enthusiasm for vitamin D supplements. Residual confounding or reverse causation may explain some of the discrepancy between the observational and trial results. At this time, vitamin D supplements should not be prescribed for the primary purpose of CVD prevention. Adding to this complexity is the fact that many adults take vitamin D and calcium supplements together for bone health, and there is some concern (albeit inconclusive) related to calcium use and increased CVD risk. In this light, it may be best to achieve the recommended daily allowances of calcium intake through food and reserve calcium supplementation only for those at risk for calcium intake deficiency, with the smallest dosage needed after dietary modifications have been exhausted. In this review, we discuss vitamin D and calcium supplementation and how they may affect cardiovascular health.

Authors+Show Affiliations

JOHNS HOPKINS SCHOOL OF MEDICINE, BALTIMORE, MARYLAND.JOHNS HOPKINS SCHOOL OF MEDICINE, BALTIMORE, MARYLAND.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31687100

Citation

Heravi, Amir S., and Erin D. Michos. "Vitamin D and Calcium Supplements: Helpful, Harmful, or Neutral for Cardiovascular Risk?" Methodist DeBakey Cardiovascular Journal, vol. 15, no. 3, 2019, pp. 207-213.
Heravi AS, Michos ED. Vitamin D and Calcium Supplements: Helpful, Harmful, or Neutral for Cardiovascular Risk? Methodist Debakey Cardiovasc J. 2019;15(3):207-213.
Heravi, A. S., & Michos, E. D. (2019). Vitamin D and Calcium Supplements: Helpful, Harmful, or Neutral for Cardiovascular Risk? Methodist DeBakey Cardiovascular Journal, 15(3), pp. 207-213. doi:10.14797/mdcj-15-3-207.
Heravi AS, Michos ED. Vitamin D and Calcium Supplements: Helpful, Harmful, or Neutral for Cardiovascular Risk. Methodist Debakey Cardiovasc J. 2019;15(3):207-213. PubMed PMID: 31687100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and Calcium Supplements: Helpful, Harmful, or Neutral for Cardiovascular Risk? AU - Heravi,Amir S, AU - Michos,Erin D, PY - 2019/11/6/entrez PY - 2019/11/7/pubmed PY - 2020/1/3/medline KW - calcium KW - cardiovascular risk KW - supplements KW - vitamin D SP - 207 EP - 213 JF - Methodist DeBakey cardiovascular journal JO - Methodist Debakey Cardiovasc J VL - 15 IS - 3 N2 - Vitamin D has traditionally been known as the "bone vitamin". However, a large body of observational data has also linked low concentrations of serum 25-hydroxyvitamin D (25[OH]D), the primary storage form of vitamin D, to an increased risk of incident cardiovascular disease (CVD) and mortality, garnering public excitement about the purported nonskeletal benefits of vitamin D. Despite this, more recent meta-analyses and randomized clinical trials have failed to find a beneficial effect of vitamin D supplements on CVD and cancer outcomes. These findings, along with the lack of consensus on optimal serum 25(OH)D concentrations, have dampened some of the initial enthusiasm for vitamin D supplements. Residual confounding or reverse causation may explain some of the discrepancy between the observational and trial results. At this time, vitamin D supplements should not be prescribed for the primary purpose of CVD prevention. Adding to this complexity is the fact that many adults take vitamin D and calcium supplements together for bone health, and there is some concern (albeit inconclusive) related to calcium use and increased CVD risk. In this light, it may be best to achieve the recommended daily allowances of calcium intake through food and reserve calcium supplementation only for those at risk for calcium intake deficiency, with the smallest dosage needed after dietary modifications have been exhausted. In this review, we discuss vitamin D and calcium supplementation and how they may affect cardiovascular health. SN - 1947-6108 UR - https://www.unboundmedicine.com/medline/citation/31687100/Vitamin_D_and_Calcium_Supplements:_Helpful_Harmful_or_Neutral_for_Cardiovascular_Risk L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31687100/ DB - PRIME DP - Unbound Medicine ER -