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Decreased retinal thickness in patients with Alzheimer's disease is correlated with disease severity.
PLoS One. 2019; 14(11):e0224180.Plos

Abstract

BACKGROUND AND PURPOSE

The loss of retinal ganglion cells observed in Alzheimer's disease (AD) may be attributable to a neurodegeneration of the neuro-retinal structure. Amnestic mild cognitive impairment (aMCI) has been considered a prodromal stage of AD. We evaluated retinal thicknesses in patients with aMCI and AD compared to healthy controls using spectral-domain optical coherence tomography (OCT) to investigate whether changes in retinal thickness are correlated with the clinical severity of dementia.

METHODS

Patients with aMCI (n = 14), mild to moderate AD (n = 7), severe AD (n = 9), and age-matched controls (n = 17) underwent neuro-ophthalmologic examinations. Global deterioration scale (GDS), clinical dementia rating (CDR), and mini-mental status examination (MMSE) were used to evaluate the clinical overall severity of dementia. The thicknesses of the peripapillary retinal nerve fiber layer (RNFL), total macula, and macular ganglion cell-inner plexiform layer (GC-IPL) were measured using Cirrus HD-OCT.

RESULTS

The severe AD group had overall significantly thinner GC-IPL, total macula, and peripapillary RNFL compared to the controls (p<0.05). In the mild to moderate AD group, the total macula, average RNFL, and superior RNFL thickness were each significantly reduced compared to controls (p<0.05). The aMCI group had reduced total macula, average RNFL, and inferior RNFL thickness, but there were no significant differences compared to the controls. The GDS and CDR scores had a negative correlation with the thickness of the GC-IPL and the total macula. The MMSE scores had a positive correlation with both the total macular and average RNFL thickness, when adjusted for age (p<0.05).

CONCLUSIONS

This study confirmed that retinal thickness is decreased in AD patients. There is a correlation between reduced retinal thickness and the clinical severity of dementia.

Authors+Show Affiliations

Department of Neurology, Dankook University College of Medicine, Dankook University Hospital, Cheonan, Korea.Department of Neurology, Dankook University College of Medicine, Dankook University Hospital, Cheonan, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31689310

Citation

Kim, Jae-Il, and Bong-Hui Kang. "Decreased Retinal Thickness in Patients With Alzheimer's Disease Is Correlated With Disease Severity." PloS One, vol. 14, no. 11, 2019, pp. e0224180.
Kim JI, Kang BH. Decreased retinal thickness in patients with Alzheimer's disease is correlated with disease severity. PLoS One. 2019;14(11):e0224180.
Kim, J. I., & Kang, B. H. (2019). Decreased retinal thickness in patients with Alzheimer's disease is correlated with disease severity. PloS One, 14(11), e0224180. https://doi.org/10.1371/journal.pone.0224180
Kim JI, Kang BH. Decreased Retinal Thickness in Patients With Alzheimer's Disease Is Correlated With Disease Severity. PLoS One. 2019;14(11):e0224180. PubMed PMID: 31689310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased retinal thickness in patients with Alzheimer's disease is correlated with disease severity. AU - Kim,Jae-Il, AU - Kang,Bong-Hui, Y1 - 2019/11/05/ PY - 2019/06/19/received PY - 2019/10/07/accepted PY - 2019/11/6/entrez PY - 2019/11/7/pubmed PY - 2020/4/3/medline SP - e0224180 EP - e0224180 JF - PloS one JO - PLoS One VL - 14 IS - 11 N2 - BACKGROUND AND PURPOSE: The loss of retinal ganglion cells observed in Alzheimer's disease (AD) may be attributable to a neurodegeneration of the neuro-retinal structure. Amnestic mild cognitive impairment (aMCI) has been considered a prodromal stage of AD. We evaluated retinal thicknesses in patients with aMCI and AD compared to healthy controls using spectral-domain optical coherence tomography (OCT) to investigate whether changes in retinal thickness are correlated with the clinical severity of dementia. METHODS: Patients with aMCI (n = 14), mild to moderate AD (n = 7), severe AD (n = 9), and age-matched controls (n = 17) underwent neuro-ophthalmologic examinations. Global deterioration scale (GDS), clinical dementia rating (CDR), and mini-mental status examination (MMSE) were used to evaluate the clinical overall severity of dementia. The thicknesses of the peripapillary retinal nerve fiber layer (RNFL), total macula, and macular ganglion cell-inner plexiform layer (GC-IPL) were measured using Cirrus HD-OCT. RESULTS: The severe AD group had overall significantly thinner GC-IPL, total macula, and peripapillary RNFL compared to the controls (p<0.05). In the mild to moderate AD group, the total macula, average RNFL, and superior RNFL thickness were each significantly reduced compared to controls (p<0.05). The aMCI group had reduced total macula, average RNFL, and inferior RNFL thickness, but there were no significant differences compared to the controls. The GDS and CDR scores had a negative correlation with the thickness of the GC-IPL and the total macula. The MMSE scores had a positive correlation with both the total macular and average RNFL thickness, when adjusted for age (p<0.05). CONCLUSIONS: This study confirmed that retinal thickness is decreased in AD patients. There is a correlation between reduced retinal thickness and the clinical severity of dementia. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/31689310/Decreased_retinal_thickness_in_patients_with_Alzheimer's_disease_is_correlated_with_disease_severity_ L2 - https://dx.plos.org/10.1371/journal.pone.0224180 DB - PRIME DP - Unbound Medicine ER -