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Association between Helicobacter pylori infection and nonalcoholic fatty liver: A meta-analysis.
Medicine (Baltimore). 2019 Nov; 98(44):e17781.M

Abstract

BACKGROUND

Opinion regarding whether Helicobacter pylori infection can promote the occurrence and development of nonalcoholic fatty liver (NAFLD) is divided. Therefore, we aimed to assess the exact relationship between H pylori infection and NAFLD by integrating all available data.

METHODS

The articles about H pylori infection and NAFLD were collected by searching the databases of PubMed, Embase, Web of Science, Scopus, China National Knowledge Infrastructure, and WanFang. The random-effects model was used for data analysis, followed by subgroup analysis and meta-regression to explore sources of heterogeneity.

RESULTS

Twenty-one articles were included in the study. Pooled analysis showed that H pylori infection indeed promoted NAFLD. Subgroup analysis and regression analysis showed that case-control ratio may be one of the sources of heterogeneity.

CONCLUSIONS

H pylori infection is indeed one of the factors that promotes the progression of NAFLD for the Asian population. This provides new approaches for clinical prevention and treatment for NAFLD.

Authors+Show Affiliations

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University.Biological Therapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

31689846

Citation

Liu, Rongqiang, et al. "Association Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver: a Meta-analysis." Medicine, vol. 98, no. 44, 2019, pp. e17781.
Liu R, Liu Q, He Y, et al. Association between Helicobacter pylori infection and nonalcoholic fatty liver: A meta-analysis. Medicine (Baltimore). 2019;98(44):e17781.
Liu, R., Liu, Q., He, Y., Shi, W., Xu, Q., Yuan, Q., Lin, Q., Li, B., Ye, L., Min, Y., Zhu, P., & Shao, Y. (2019). Association between Helicobacter pylori infection and nonalcoholic fatty liver: A meta-analysis. Medicine, 98(44), e17781. https://doi.org/10.1097/MD.0000000000017781
Liu R, et al. Association Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver: a Meta-analysis. Medicine (Baltimore). 2019;98(44):e17781. PubMed PMID: 31689846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Helicobacter pylori infection and nonalcoholic fatty liver: A meta-analysis. AU - Liu,Rongqiang, AU - Liu,Qiuli, AU - He,Ying, AU - Shi,Wenqing, AU - Xu,Qianhui, AU - Yuan,Qing, AU - Lin,Qi, AU - Li,Biao, AU - Ye,Lei, AU - Min,Youlan, AU - Zhu,Peiwen, AU - Shao,Yi, PY - 2019/11/7/entrez PY - 2019/11/7/pubmed PY - 2019/11/26/medline SP - e17781 EP - e17781 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 44 N2 - BACKGROUND: Opinion regarding whether Helicobacter pylori infection can promote the occurrence and development of nonalcoholic fatty liver (NAFLD) is divided. Therefore, we aimed to assess the exact relationship between H pylori infection and NAFLD by integrating all available data. METHODS: The articles about H pylori infection and NAFLD were collected by searching the databases of PubMed, Embase, Web of Science, Scopus, China National Knowledge Infrastructure, and WanFang. The random-effects model was used for data analysis, followed by subgroup analysis and meta-regression to explore sources of heterogeneity. RESULTS: Twenty-one articles were included in the study. Pooled analysis showed that H pylori infection indeed promoted NAFLD. Subgroup analysis and regression analysis showed that case-control ratio may be one of the sources of heterogeneity. CONCLUSIONS: H pylori infection is indeed one of the factors that promotes the progression of NAFLD for the Asian population. This provides new approaches for clinical prevention and treatment for NAFLD. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/31689846/Association_between_Helicobacter_pylori_infection_and_nonalcoholic_fatty_liver:_A_meta_analysis_ L2 - https://doi.org/10.1097/MD.0000000000017781 DB - PRIME DP - Unbound Medicine ER -