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A case of hypersensitivity pneumonitis in a worker exposed to terephthalic acid in the production of polyethylene terephthalate.
Int J Occup Med Environ Health 2020; 33(1):119-123IJ

Abstract

Occupational hypersensitivity pneumonitis (OHP) is an interstitial lung disease caused by sensitization to an inhaled antigen. Polyethylene terephthalate (PET) is mainly used for disposable beverage bottles. A clinical case of hypersensitivity pneumonitis (HP) in a 66-year-old patient in the follow-up as a worker formerly exposed to asbestos is presented. At the first visit in 2012 a diagnosis of asbestosis and pleural plaques was formulated. In 2017 the high resolution computed tomography was performed demonstrating a slight progression of the pulmonary fibrosis, while physical examinations revealed inspiratory crackles on auscultation, and lung function tests showed a decreased diffusing capacity for carbon monoxide. The radiological and histological pictures were compatible with HP. From 1992 to 2013 the patient worked in a chemical company that produced PET for disposable beverage bottles. A diagnosis of OHP was made, and the most likely causative agents were terephthalic acid and dimethyl terephthalate. To the best of the authors' knowledge, this is the first report of an OHP case in PET production. Int J Occup Med Environ Health. 2020;33(1):119-23.

Authors+Show Affiliations

University of Siena, Siena, Italy (Department of Medical Biotechnology, Unit of Occupational Medicine, University Hospital of Siena).University of Siena, Siena, Italy (Department of Medical Biotechnology, Unit of Occupational Medicine, University Hospital of Siena).University Hospital of Siena, Siena, Italy (Unit of Pathology).University of Siena, Siena, Italy (Department of Medicine, Surgery and Neuroscience, Unit of Diagnostic Imaging, University Hospital of Siena).University of Siena, Siena, Italy (Department of Medicine, Surgery and Neuroscience, Unit of Diagnostic Imaging, University Hospital of Siena).

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31691678

Citation

Sartorelli, Pietro, et al. "A Case of Hypersensitivity Pneumonitis in a Worker Exposed to Terephthalic Acid in the Production of Polyethylene Terephthalate." International Journal of Occupational Medicine and Environmental Health, vol. 33, no. 1, 2020, pp. 119-123.
Sartorelli P, d'Hauw G, Spina D, et al. A case of hypersensitivity pneumonitis in a worker exposed to terephthalic acid in the production of polyethylene terephthalate. Int J Occup Med Environ Health. 2020;33(1):119-123.
Sartorelli, P., d'Hauw, G., Spina, D., Volterrani, L., & Mazzei, M. A. (2020). A case of hypersensitivity pneumonitis in a worker exposed to terephthalic acid in the production of polyethylene terephthalate. International Journal of Occupational Medicine and Environmental Health, 33(1), pp. 119-123. doi:10.13075/ijomeh.1896.01465.
Sartorelli P, et al. A Case of Hypersensitivity Pneumonitis in a Worker Exposed to Terephthalic Acid in the Production of Polyethylene Terephthalate. Int J Occup Med Environ Health. 2020 Jan 17;33(1):119-123. PubMed PMID: 31691678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of hypersensitivity pneumonitis in a worker exposed to terephthalic acid in the production of polyethylene terephthalate. AU - Sartorelli,Pietro, AU - d'Hauw,Gabriele, AU - Spina,Donatella, AU - Volterrani,Luca, AU - Mazzei,Maria Antonietta, Y1 - 2019/10/30/ PY - 2019/11/7/pubmed PY - 2019/11/7/medline PY - 2019/11/7/entrez KW - asbestos KW - extrinsic allergic alveolitis KW - pleural plaques KW - polyethylene terephthalate KW - pulmonary fibrosis KW - terephthalic acid SP - 119 EP - 123 JF - International journal of occupational medicine and environmental health JO - Int J Occup Med Environ Health VL - 33 IS - 1 N2 - Occupational hypersensitivity pneumonitis (OHP) is an interstitial lung disease caused by sensitization to an inhaled antigen. Polyethylene terephthalate (PET) is mainly used for disposable beverage bottles. A clinical case of hypersensitivity pneumonitis (HP) in a 66-year-old patient in the follow-up as a worker formerly exposed to asbestos is presented. At the first visit in 2012 a diagnosis of asbestosis and pleural plaques was formulated. In 2017 the high resolution computed tomography was performed demonstrating a slight progression of the pulmonary fibrosis, while physical examinations revealed inspiratory crackles on auscultation, and lung function tests showed a decreased diffusing capacity for carbon monoxide. The radiological and histological pictures were compatible with HP. From 1992 to 2013 the patient worked in a chemical company that produced PET for disposable beverage bottles. A diagnosis of OHP was made, and the most likely causative agents were terephthalic acid and dimethyl terephthalate. To the best of the authors' knowledge, this is the first report of an OHP case in PET production. Int J Occup Med Environ Health. 2020;33(1):119-23. SN - 1896-494X UR - https://www.unboundmedicine.com/medline/citation/31691678/A_case_of_hypersensitivity_pneumonitis_in_a_worker_exposed_to_terephthalic_acid_in_the_production_of_polyethylene_terephthalate L2 - https://doi.org/10.13075/ijomeh.1896.01465 DB - PRIME DP - Unbound Medicine ER -