TY - JOUR T1 - Specific Signatures of Serum miRNAs as Potential Biomarkers to Discriminate Clinically Similar Neurodegenerative and Vascular-Related Diseases. AU - Barbagallo,Cristina, AU - Mostile,Giovanni, AU - Baglieri,Gloriangela, AU - Giunta,Flavia, AU - Luca,Antonina, AU - Raciti,Loredana, AU - Zappia,Mario, AU - Purrello,Michele, AU - Ragusa,Marco, AU - Nicoletti,Alessandra, Y1 - 2019/11/06/ PY - 2019/06/19/received PY - 2019/10/25/accepted PY - 2019/11/7/pubmed PY - 2020/12/29/medline PY - 2019/11/7/entrez KW - Alzheimer’s disease KW - Exosomes KW - Parkinson’s disease KW - Vascular dementia KW - Vascular parkinsonism KW - microRNAs SP - 531 EP - 546 JF - Cellular and molecular neurobiology JO - Cell Mol Neurobiol VL - 40 IS - 4 N2 - Neurodegenerative diseases (NDs) are age-dependent; among them, Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent. Similarly, cerebrovascular damage can induce the development of vascular-related disorders that share common features with AD and PD, respectively, named vascular dementia (VD) and vascular parkinsonism (VP). To date, ND diagnosis is mainly clinical; therefore, since these disorders show similar symptoms, their correct discrimination may be difficult. We detected 23 ND-associated microRNAs (miRNAs) by literature mining and investigated their serum expression in a cohort of 139 patients including AD, PD, VD, and VP patients and healthy controls. TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR-142-3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. By computing logistic regression models and ROC curves, we identified signatures of neuro-miRNAs specific for each disease, showing good diagnostic performance. Interestingly, we found that miR-23a, miR-29a, miR-34b, and miR-125b exhibited a different distribution between exosomes and vesicle-free serum, suggesting a heterogeneity of secretion for these miRNAs. Our results suggest that miRNA signatures could discriminate in a non-invasive manner neurodegenerative disorders, thus improving clinical diagnoses. SN - 1573-6830 UR - https://www.unboundmedicine.com/medline/citation/31691877/Specific_Signatures_of_Serum_miRNAs_as_Potential_Biomarkers_to_Discriminate_Clinically_Similar_Neurodegenerative_and_Vascular_Related_Diseases_ DB - PRIME DP - Unbound Medicine ER -