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Characteristics of Corneal Endotheliitis among Different Viruses by in Vivo Confocal Microscopy.

Abstract

Objectives:

To explore the cellular morphological characteristics and changes in corneal endotheliitis among different viruses by in vivo confocal microscopy (IVCM).

Methods:

Corneal confocal images of 44 eyes of 44 patients with HSV, VZV, CMV and EBV corneal endotheliitis were studied retrospectively. Corneal confocal images of 44 normal eyes were used as controls.

Results:

The pathogens included cytomegalovirus (n = 20), herpes simplex virus (n = 8), varicella zoster virus (n = 10), and Epstein Barr virus (n = 6). There were no differences in the evaluated structures among the different viruses except for the lengths of the subbasal nerves and Langerhans cell densities. Deviations in endothelial cell layers were not significant among different viruses except for owl's eye morphology.

Conclusion:

ICVM can assist in diagnosing endotheliitis. The results demonstrate that changes in the cornea were not different among the various viruses except for owl's eye morphology, the lengths of the subbasal nerves and Langerhans cell densities.

Authors+Show Affiliations

Department of Ophthalmology, Peking University Third Hospital, Beijing, China.Department of Ophthalmology, Peking University Third Hospital, Beijing, China.Department of Ophthalmology, Peking University Third Hospital, Beijing, China.Department of Ophthalmology, Peking University Third Hospital, Beijing, China.Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31697212

Citation

Peng, Rong-Mei, et al. "Characteristics of Corneal Endotheliitis Among Different Viruses By in Vivo Confocal Microscopy." Ocular Immunology and Inflammation, 2019, pp. 1-9.
Peng RM, Guo YX, Xiao GG, et al. Characteristics of Corneal Endotheliitis among Different Viruses by in Vivo Confocal Microscopy. Ocul Immunol Inflamm. 2019.
Peng, R. M., Guo, Y. X., Xiao, G. G., Li, C. D., & Hong, J. (2019). Characteristics of Corneal Endotheliitis among Different Viruses by in Vivo Confocal Microscopy. Ocular Immunology and Inflammation, pp. 1-9. doi:10.1080/09273948.2019.1678648.
Peng RM, et al. Characteristics of Corneal Endotheliitis Among Different Viruses By in Vivo Confocal Microscopy. Ocul Immunol Inflamm. 2019 Nov 7;1-9. PubMed PMID: 31697212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of Corneal Endotheliitis among Different Viruses by in Vivo Confocal Microscopy. AU - Peng,Rong-Mei, AU - Guo,Yu-Xin, AU - Xiao,Ge-Ge, AU - Li,Chen-Di, AU - Hong,Jing, Y1 - 2019/11/07/ PY - 2019/11/8/entrez KW - cytomegalovirus KW - herpes simplex virus KW - in vivo laser-scanning confocal microscopy KW - varicella zoster virus KW - viral corneal endotheliitis SP - 1 EP - 9 JF - Ocular immunology and inflammation JO - Ocul. Immunol. Inflamm. N2 - Objectives: To explore the cellular morphological characteristics and changes in corneal endotheliitis among different viruses by in vivo confocal microscopy (IVCM).Methods: Corneal confocal images of 44 eyes of 44 patients with HSV, VZV, CMV and EBV corneal endotheliitis were studied retrospectively. Corneal confocal images of 44 normal eyes were used as controls.Results: The pathogens included cytomegalovirus (n = 20), herpes simplex virus (n = 8), varicella zoster virus (n = 10), and Epstein Barr virus (n = 6). There were no differences in the evaluated structures among the different viruses except for the lengths of the subbasal nerves and Langerhans cell densities. Deviations in endothelial cell layers were not significant among different viruses except for owl's eye morphology.Conclusion: ICVM can assist in diagnosing endotheliitis. The results demonstrate that changes in the cornea were not different among the various viruses except for owl's eye morphology, the lengths of the subbasal nerves and Langerhans cell densities. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/31697212/Characteristics_of_Corneal_Endotheliitis_among_Different_Viruses_by_in_Vivo_Confocal_Microscopy L2 - http://www.tandfonline.com/doi/full/10.1080/09273948.2019.1678648 DB - PRIME DP - Unbound Medicine ER -