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Causes of Hypertensive Anterior Uveitis in Thailand.

Abstract

Purpose:

To determine the prevalence of viral infections in patients with hypertensive anterior uveitis in Thailand from polymerase chain reaction (PCR) of aqueous humor.

Methods:

Thirty-one patients with anterior uveitis with intraocular pressure (IOP) above 25 mmHg were included for PCR analysis for cytomegalovirus (CMV), herpes simplex (HSV), varicella-zoster (VZV), rubella, chikungunya and Zika virus.

Results:

The prevalence of PCR-positive results was 32%, including 19% for CMV, 10% for HSV, and 3% for VZV; PCR for other tested viruses demonstrated negative results. PCR-positive patients exhibited satisfactory IOP control with antiviral and anti-glaucomatous treatment compared to PCR-negative patients, and more than half of PCR-negative patients required glaucoma surgery within 12 months (P = .01).

Conclusion:

PCR evidence of infection with herpes group viruses was found in one-third of patients with hypertensive anterior uveitis; CMV being the most common pathogen. The PCR-positive group generally responded well to a combination of antiviral and anti-glaucoma treatment.

Authors+Show Affiliations

Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.Department of Ophthalmology, Erasmus Medical Centre, Rotterdam, the Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31697590

Citation

Khieu, Chansathya, et al. "Causes of Hypertensive Anterior Uveitis in Thailand." Ocular Immunology and Inflammation, 2019, pp. 1-7.
Khieu C, Kongyai N, Pathanapitoon K, et al. Causes of Hypertensive Anterior Uveitis in Thailand. Ocul Immunol Inflamm. 2019.
Khieu, C., Kongyai, N., Pathanapitoon, K., Van Der Eijk, A. A., & Rothova, A. (2019). Causes of Hypertensive Anterior Uveitis in Thailand. Ocular Immunology and Inflammation, pp. 1-7. doi:10.1080/09273948.2019.1678651.
Khieu C, et al. Causes of Hypertensive Anterior Uveitis in Thailand. Ocul Immunol Inflamm. 2019 Nov 7;1-7. PubMed PMID: 31697590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Causes of Hypertensive Anterior Uveitis in Thailand. AU - Khieu,Chansathya, AU - Kongyai,Natedao, AU - Pathanapitoon,Kessara, AU - Van Der Eijk,Annemiek A, AU - Rothova,Aniki, Y1 - 2019/11/07/ PY - 2019/11/8/entrez PY - 2019/11/8/pubmed PY - 2019/11/8/medline KW - Cytomegalovirus KW - herpes simplex virus KW - hypertensive anterior uveitis KW - polymerase chain reaction KW - varicella-zoster virus SP - 1 EP - 7 JF - Ocular immunology and inflammation JO - Ocul. Immunol. Inflamm. N2 - Purpose: To determine the prevalence of viral infections in patients with hypertensive anterior uveitis in Thailand from polymerase chain reaction (PCR) of aqueous humor.Methods: Thirty-one patients with anterior uveitis with intraocular pressure (IOP) above 25 mmHg were included for PCR analysis for cytomegalovirus (CMV), herpes simplex (HSV), varicella-zoster (VZV), rubella, chikungunya and Zika virus.Results: The prevalence of PCR-positive results was 32%, including 19% for CMV, 10% for HSV, and 3% for VZV; PCR for other tested viruses demonstrated negative results. PCR-positive patients exhibited satisfactory IOP control with antiviral and anti-glaucomatous treatment compared to PCR-negative patients, and more than half of PCR-negative patients required glaucoma surgery within 12 months (P = .01).Conclusion: PCR evidence of infection with herpes group viruses was found in one-third of patients with hypertensive anterior uveitis; CMV being the most common pathogen. The PCR-positive group generally responded well to a combination of antiviral and anti-glaucoma treatment. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/31697590/Causes_of_Hypertensive_Anterior_Uveitis_in_Thailand L2 - http://www.tandfonline.com/doi/full/10.1080/09273948.2019.1678651 DB - PRIME DP - Unbound Medicine ER -