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A New Possible Mechanism by Which Punicalagin Protects against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway.
J Agric Food Chem. 2019 Dec 18; 67(50):13948-13959.JA

Abstract

The aim of this study was to investigate the protective effect of punicalagin (PU), which is a main component of pomegranate polyphenols, against liver injury induced by Type 2 diabetes mellitus (T2DM) and to explore the molecular mechanism based on autophagy in vivo and in vitro. In T2DM mice, we found that PU significantly improved liver histology, reversed serum biochemical abnormalities, and increased the autophagosome number in the liver. In HepG2 cells cultured in a high-glucose environment, PU upregulated the glucose uptake level. Both in vivo and in vitro, PU upregulated the expression of autophagy-related proteins, such as LC3b and p62, and reduced the phosphorylated Akt/total Akt and phosphorylated FoxO3a/total FoxO3a protein ratios, and these effects were enhanced by LY294002 (a PI3K/Akt inhibitor). In summary, our current findings suggest that PU protects against liver injury induced by T2DM by restoring autophagy through the Akt/FoxO3a signaling pathway.

Authors+Show Affiliations

Xiangya School of Public Health , Central South University , Changsha 410128 , China.Xiangya School of Public Health , Central South University , Changsha 410128 , China.Xiangya School of Public Health , Central South University , Changsha 410128 , China.Xiangya School of Public Health , Central South University , Changsha 410128 , China.Xiangya School of Public Health , Central South University , Changsha 410128 , China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31698901

Citation

Zhang, Yahui, et al. "A New Possible Mechanism By Which Punicalagin Protects Against Liver Injury Induced By Type 2 Diabetes Mellitus: Upregulation of Autophagy Via the Akt/FoxO3a Signaling Pathway." Journal of Agricultural and Food Chemistry, vol. 67, no. 50, 2019, pp. 13948-13959.
Zhang Y, Cao Y, Chen J, et al. A New Possible Mechanism by Which Punicalagin Protects against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway. J Agric Food Chem. 2019;67(50):13948-13959.
Zhang, Y., Cao, Y., Chen, J., Qin, H., & Yang, L. (2019). A New Possible Mechanism by Which Punicalagin Protects against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway. Journal of Agricultural and Food Chemistry, 67(50), 13948-13959. https://doi.org/10.1021/acs.jafc.9b05910
Zhang Y, et al. A New Possible Mechanism By Which Punicalagin Protects Against Liver Injury Induced By Type 2 Diabetes Mellitus: Upregulation of Autophagy Via the Akt/FoxO3a Signaling Pathway. J Agric Food Chem. 2019 Dec 18;67(50):13948-13959. PubMed PMID: 31698901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A New Possible Mechanism by Which Punicalagin Protects against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway. AU - Zhang,Yahui, AU - Cao,Yuan, AU - Chen,Jihua, AU - Qin,Hong, AU - Yang,Lina, Y1 - 2019/12/09/ PY - 2019/11/9/pubmed PY - 2019/12/31/medline PY - 2019/11/9/entrez KW - Akt/FoxO3a signaling pathway KW - T2DM KW - autophagy KW - liver injury KW - punicalagin SP - 13948 EP - 13959 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 67 IS - 50 N2 - The aim of this study was to investigate the protective effect of punicalagin (PU), which is a main component of pomegranate polyphenols, against liver injury induced by Type 2 diabetes mellitus (T2DM) and to explore the molecular mechanism based on autophagy in vivo and in vitro. In T2DM mice, we found that PU significantly improved liver histology, reversed serum biochemical abnormalities, and increased the autophagosome number in the liver. In HepG2 cells cultured in a high-glucose environment, PU upregulated the glucose uptake level. Both in vivo and in vitro, PU upregulated the expression of autophagy-related proteins, such as LC3b and p62, and reduced the phosphorylated Akt/total Akt and phosphorylated FoxO3a/total FoxO3a protein ratios, and these effects were enhanced by LY294002 (a PI3K/Akt inhibitor). In summary, our current findings suggest that PU protects against liver injury induced by T2DM by restoring autophagy through the Akt/FoxO3a signaling pathway. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/31698901/A_New_Possible_Mechanism_by_Which_Punicalagin_Protects_against_Liver_Injury_Induced_by_Type_2_Diabetes_Mellitus:_Upregulation_of_Autophagy_via_the_Akt/FoxO3a_Signaling_Pathway_ L2 - https://dx.doi.org/10.1021/acs.jafc.9b05910 DB - PRIME DP - Unbound Medicine ER -