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Lower limb arterial intervention or autologous platelet-rich gel treatment of diabetic lower extremity arterial disease patients with foot ulcers.
Ann Transl Med 2019; 7(18):485AT

Abstract

Background

To investigate whether lower limb vascular intervention or autologous platelet-rich gel (APG) treatment would benefit diabetic lower extremity arterial disease (LEAD) patients with foot ulcers.

Methods

A total of 82 diabetic LEAD patients with foot ulcers were recruited and divided into three groups: group A (30 patients received basal treatment), group B (21 patients received basal and APG treatment), and group C (31 patients received basal and lower limb vascular intervention treatment). All patients underwent routine follow-up visits for 6 months. The baseline characteristics and parameters were examined. After treatment, changes in all parameters from baseline were recorded. The differences between groups and the relationship among each parameter were determined.

Results

There were no differences in the ankle brachial index (ABI) or major amputation between groups A and B (P>0.05). Compared with groups A and B, the ABI and major amputation rate of group C were improved (P<0.05). There were no significant differences in transcutaneous oxygen partial pressure (TcPO2), the heal rate or minor amputation between groups A and C (P>0.05). Compared with groups A and C, TcPO2, the heal rate and minor amputation of group B were improved (P<0.05). The logistic regression analysis indicated that major amputation was mainly associated with the ABI, and minor amputation was mainly associated with TcPO2. Lower limb vascular intervention improves the ABI and reduces major amputation, and APG improves TcPO2 and reduces minor amputation.

Conclusions

In diabetic LEAD patients with foot ulcers, major amputation was mainly associated with the ABI, while minor amputation was mainly associated with TcPO2. Interventional surgery (angioplasty) mainly improves the ABI, reduces the incidence of major amputation and improves the macrovasculature, and APG mainly improves local TcPO2, reduces the incidence of minor amputation and improves the microcirculation.

Authors+Show Affiliations

Endocrinology and Nephrology Department, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing 400030, China.Endocrinology Department, the First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.Endocrinology Department, the First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.Endocrinology Department, the First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.Endocrinology Department, the First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.Endocrinology Department, the First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.Endocrinology Department, the First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China.Endocrinology and Nephrology Department, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing 400030, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31700921

Citation

Pu, Danlan, et al. "Lower Limb Arterial Intervention or Autologous Platelet-rich Gel Treatment of Diabetic Lower Extremity Arterial Disease Patients With Foot Ulcers." Annals of Translational Medicine, vol. 7, no. 18, 2019, p. 485.
Pu D, Lei X, Leng W, et al. Lower limb arterial intervention or autologous platelet-rich gel treatment of diabetic lower extremity arterial disease patients with foot ulcers. Ann Transl Med. 2019;7(18):485.
Pu, D., Lei, X., Leng, W., Zheng, Y., Chen, L., Liang, Z., ... Wu, Q. (2019). Lower limb arterial intervention or autologous platelet-rich gel treatment of diabetic lower extremity arterial disease patients with foot ulcers. Annals of Translational Medicine, 7(18), p. 485. doi:10.21037/atm.2019.07.87.
Pu D, et al. Lower Limb Arterial Intervention or Autologous Platelet-rich Gel Treatment of Diabetic Lower Extremity Arterial Disease Patients With Foot Ulcers. Ann Transl Med. 2019;7(18):485. PubMed PMID: 31700921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lower limb arterial intervention or autologous platelet-rich gel treatment of diabetic lower extremity arterial disease patients with foot ulcers. AU - Pu,Danlan, AU - Lei,Xiaotian, AU - Leng,Weiling, AU - Zheng,Yanling, AU - Chen,Liu, AU - Liang,Ziwen, AU - Chen,Bing, AU - Wu,Qinan, PY - 2019/11/9/entrez PY - 2019/11/9/pubmed PY - 2019/11/9/medline KW - Diabetic foot ulcer (DFU) KW - ankle brachial index (ABI) KW - autologous platelet-rich gel (APG) KW - lower limb vascular intervention KW - transcutaneous oxygen partial pressure (TcPO2) SP - 485 EP - 485 JF - Annals of translational medicine JO - Ann Transl Med VL - 7 IS - 18 N2 - Background: To investigate whether lower limb vascular intervention or autologous platelet-rich gel (APG) treatment would benefit diabetic lower extremity arterial disease (LEAD) patients with foot ulcers. Methods: A total of 82 diabetic LEAD patients with foot ulcers were recruited and divided into three groups: group A (30 patients received basal treatment), group B (21 patients received basal and APG treatment), and group C (31 patients received basal and lower limb vascular intervention treatment). All patients underwent routine follow-up visits for 6 months. The baseline characteristics and parameters were examined. After treatment, changes in all parameters from baseline were recorded. The differences between groups and the relationship among each parameter were determined. Results: There were no differences in the ankle brachial index (ABI) or major amputation between groups A and B (P>0.05). Compared with groups A and B, the ABI and major amputation rate of group C were improved (P<0.05). There were no significant differences in transcutaneous oxygen partial pressure (TcPO2), the heal rate or minor amputation between groups A and C (P>0.05). Compared with groups A and C, TcPO2, the heal rate and minor amputation of group B were improved (P<0.05). The logistic regression analysis indicated that major amputation was mainly associated with the ABI, and minor amputation was mainly associated with TcPO2. Lower limb vascular intervention improves the ABI and reduces major amputation, and APG improves TcPO2 and reduces minor amputation. Conclusions: In diabetic LEAD patients with foot ulcers, major amputation was mainly associated with the ABI, while minor amputation was mainly associated with TcPO2. Interventional surgery (angioplasty) mainly improves the ABI, reduces the incidence of major amputation and improves the macrovasculature, and APG mainly improves local TcPO2, reduces the incidence of minor amputation and improves the microcirculation. SN - 2305-5839 UR - https://www.unboundmedicine.com/medline/citation/31700921/Lower_limb_arterial_intervention_or_autologous_platelet_rich_gel_treatment_of_diabetic_lower_extremity_arterial_disease_patients_with_foot_ulcers_ L2 - https://doi.org/10.21037/atm.2019.07.87 DB - PRIME DP - Unbound Medicine ER -