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ATM controls DNA repair and mitochondria transfer between neighboring cells.
Cell Commun Signal 2019; 17(1):144CC

Abstract

Intercellular communication is essential for multicellular tissue vitality and homeostasis. We show that healthy cells message protective signals through direct cell-cell connections to adjacent DNA-damaged cells in a microtubule-dependent manner. In DNA-damaged cells, mitochondria restoration is facilitated by fusion with undamaged mitochondria from healthy cells and their DNA damage repair is optimized in presence of healthy cells. Both, mitochondria transfer and intercellular signaling for an enhanced DNA damage response are critically regulated by the activity of the DNA repair protein ataxia telangiectasia mutated (ATM). These healthy-to-damaged prosurvival processes sustain normal tissue integrity and may be exploitable for overcoming resistance to therapy in diseases such as cancer.

Authors+Show Affiliations

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine, Technische Universität Dresden, D-01307, Dresden, Germany.OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine, Technische Universität Dresden, D-01307, Dresden, Germany. nils.cordes@oncoray.de. Department of Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307, Dresden, Germany. nils.cordes@oncoray.de. Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology - OncoRay, D-01328, Dresden, Germany. nils.cordes@oncoray.de. German Cancer Consortium (DKTK), partner site Dresden, D-69192, Heidelberg, Germany. nils.cordes@oncoray.de. German Cancer Research Center (DKFZ), D-69192, Heidelberg, Germany. nils.cordes@oncoray.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31703695

Citation

Jin, Sha, and Nils Cordes. "ATM Controls DNA Repair and Mitochondria Transfer Between Neighboring Cells." Cell Communication and Signaling : CCS, vol. 17, no. 1, 2019, p. 144.
Jin S, Cordes N. ATM controls DNA repair and mitochondria transfer between neighboring cells. Cell Commun Signal. 2019;17(1):144.
Jin, S., & Cordes, N. (2019). ATM controls DNA repair and mitochondria transfer between neighboring cells. Cell Communication and Signaling : CCS, 17(1), p. 144. doi:10.1186/s12964-019-0472-x.
Jin S, Cordes N. ATM Controls DNA Repair and Mitochondria Transfer Between Neighboring Cells. Cell Commun Signal. 2019 Nov 8;17(1):144. PubMed PMID: 31703695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ATM controls DNA repair and mitochondria transfer between neighboring cells. AU - Jin,Sha, AU - Cordes,Nils, Y1 - 2019/11/08/ PY - 2019/07/16/received PY - 2019/10/25/accepted PY - 2019/11/10/entrez PY - 2019/11/11/pubmed PY - 2019/11/11/medline KW - Ataxia telangiectasia mutated (ATM) KW - Cell–cell communication KW - DNA damage repair KW - Genotoxic stress KW - Mitochondria exchange SP - 144 EP - 144 JF - Cell communication and signaling : CCS JO - Cell Commun. Signal VL - 17 IS - 1 N2 - Intercellular communication is essential for multicellular tissue vitality and homeostasis. We show that healthy cells message protective signals through direct cell-cell connections to adjacent DNA-damaged cells in a microtubule-dependent manner. In DNA-damaged cells, mitochondria restoration is facilitated by fusion with undamaged mitochondria from healthy cells and their DNA damage repair is optimized in presence of healthy cells. Both, mitochondria transfer and intercellular signaling for an enhanced DNA damage response are critically regulated by the activity of the DNA repair protein ataxia telangiectasia mutated (ATM). These healthy-to-damaged prosurvival processes sustain normal tissue integrity and may be exploitable for overcoming resistance to therapy in diseases such as cancer. SN - 1478-811X UR - https://www.unboundmedicine.com/medline/citation/31703695/ATM_controls_DNA_repair_and_mitochondria_transfer_between_neighboring_cells L2 - https://biosignaling.biomedcentral.com/articles/10.1186/s12964-019-0472-x DB - PRIME DP - Unbound Medicine ER -