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TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample.
Twin Res Hum Genet 2019; :1-7TR

Abstract

Meta-analyses suggest that clinical psychopathology is preceded by dimensional behavioral and cognitive phenotypes such as psychotic experiences, executive functioning, working memory and affective dysregulation that are determined by the interplay between genetic and nongenetic factors contributing to the severity of psychopathology. The liability to mental ill health can be psychometrically measured using experimental paradigms that assess neurocognitive processes such as salience attribution, sensitivity to social defeat and reward sensitivity. Here, we describe the TwinssCan, a longitudinal general population twin cohort, which comprises 1202 individuals (796 adolescent/young adult twins, 43 siblings and 363 parents) at baseline. The TwinssCan is part of the European Network of National Networks studying Gene-Environment Interactions in Schizophrenia project and recruited from the East Flanders Prospective Twin Survey. The main objective of this project is to understand psychopathology by evaluating the contribution of genetic and nongenetic factors on subclinical expressions of dimensional phenotypes at a young age before the onset of disorder and their association with neurocognitive processes, such as salience attribution, sensitivity to social defeat and reward sensitivity.

Authors+Show Affiliations

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands. Department of Neurosciences, University Psychiatric Centre KU Leuven, KU Leuven, Belgium. Brothers of Charity, University Psychiatric Centre Sint-Kamillus Bierbeek, Bierbeek, Belgium.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands. Department of Neurosciences, University Psychiatric Centre KU Leuven, KU Leuven, Belgium.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.Department of Neurosciences, University Psychiatric Centre KU Leuven, KU Leuven, Belgium.Centre of Human Genetics, University Hospitals Leuven, KU Leuven, Leuven, Belgium. Department of Obstetrics and Gynecology, Ghent University Hospitals, Ghent University, Ghent, Belgium.Department of Neurology, Ghent University Hospital, Ghent University, Ghent, Belgium.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands. Faculty of Psychology and Educational Sciences, Open University of the Netherlands, Heerlen, the Netherlands.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands. Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands. Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands. Department of Psychiatry, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, the Netherlands. Department of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, London, UK.Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, the Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31708010

Citation

Pries, Lotta-Katrin, et al. "TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample." Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies, 2019, pp. 1-7.
Pries LK, Snijders C, Menne-Lothmann C, et al. TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample. Twin Res Hum Genet. 2019.
Pries, L. K., Snijders, C., Menne-Lothmann, C., Decoster, J., van Winkel, R., Collip, D., ... Rutten, B. P. F. (2019). TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample. Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies, pp. 1-7. doi:10.1017/thg.2019.96.
Pries LK, et al. TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample. Twin Res Hum Genet. 2019 Nov 11;1-7. PubMed PMID: 31708010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample. AU - Pries,Lotta-Katrin, AU - Snijders,Clara, AU - Menne-Lothmann,Claudia, AU - Decoster,Jeroen, AU - van Winkel,Ruud, AU - Collip,Dina, AU - Delespaul,Philippe, AU - De Hert,Marc, AU - Derom,Catherine, AU - Thiery,Evert, AU - Jacobs,Nele, AU - Wichers,Marieke, AU - Guloksuz,Sinan, AU - van Os,Jim, AU - Rutten,Bart P F, Y1 - 2019/11/11/ PY - 2019/11/12/entrez KW - Psychosis KW - depression KW - environment KW - general population KW - genetics KW - reward sensitivity KW - salience attribution KW - social defeat KW - stress sensitivity KW - twins SP - 1 EP - 7 JF - Twin research and human genetics : the official journal of the International Society for Twin Studies JO - Twin Res Hum Genet N2 - Meta-analyses suggest that clinical psychopathology is preceded by dimensional behavioral and cognitive phenotypes such as psychotic experiences, executive functioning, working memory and affective dysregulation that are determined by the interplay between genetic and nongenetic factors contributing to the severity of psychopathology. The liability to mental ill health can be psychometrically measured using experimental paradigms that assess neurocognitive processes such as salience attribution, sensitivity to social defeat and reward sensitivity. Here, we describe the TwinssCan, a longitudinal general population twin cohort, which comprises 1202 individuals (796 adolescent/young adult twins, 43 siblings and 363 parents) at baseline. The TwinssCan is part of the European Network of National Networks studying Gene-Environment Interactions in Schizophrenia project and recruited from the East Flanders Prospective Twin Survey. The main objective of this project is to understand psychopathology by evaluating the contribution of genetic and nongenetic factors on subclinical expressions of dimensional phenotypes at a young age before the onset of disorder and their association with neurocognitive processes, such as salience attribution, sensitivity to social defeat and reward sensitivity. SN - 1832-4274 UR - https://www.unboundmedicine.com/medline/citation/31708010/TwinssCan_-_Gene-Environment_Interaction_in_Psychotic_and_Depressive_Intermediate_Phenotypes:_Risk_and_Protective_Factors_in_a_General_Population_Twin_Sample L2 - https://www.cambridge.org/core/product/identifier/S1832427419000963/type/journal_article DB - PRIME DP - Unbound Medicine ER -