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Psychiatric and neurodevelopmental aspects of Becker muscular dystrophy.
Neuromuscul Disord 2019; 29(12):930-939ND

Abstract

Little is known about the relationship between Becker Muscular Dystrophy (BMD) and mental disorders. This study aimed to clarify whether BMD is a risk factor for psychiatric diseases. We asked genetically or immunohistochemically confirmed BMD patients to participate in the study interview. Participants who consented to psychiatric tests underwent further assessments of intellectual, psychological, and neurodevelopmental disorders. In total, 76 (73%) of 105 BMD patients (median age, 37 years) completed the interview. Of these, 6 had developmental disorders (mental retardation, pervasive developmental disorder), 33/76 (43%) experienced bullying in school, 11 exhibited problematic behaviors such as cutting class and violent incidents, and 16 had psychiatric disorders (schizophrenia spectrum, 5; depressive spectrum, 4; stress-related disorders, 3; obsessive-compulsive and related disorders, 2; somatic symptom and related disorders, 2; bipolar and related disorders, 1). Mean IQ was normal, whereas 13/40 (32.5%) of participants were in a depressive state. High trait anxiety was found in 20/40 (50%) of patients, while 15/40 (38.5%) were in an anxious state. Review of MRI data from 14 participants revealed brain atrophy caused solely by BMD and unrelated to any other complication. Our findings suggest that BMD patients are at risk of developing psychiatric disorders. Physical handicap or bullying may influence their mental state, as many of them have high trait anxiety. Parents, teachers, and supporters should be mindful of the daily environment of BMD patients and provide support to help them cope with stress.

Authors+Show Affiliations

Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan. Electronic address: yoshimur@ncnp.go.jp.Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan.Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan; Department of Laboratory Medicine, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan.Department of Laboratory Medicine, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan.Department of Laboratory Medicine, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan; Medical Genome Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan; Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.Faculty of Medicine, Department of Biostatistics, Tsukuba University, 1-1-1 Tennnodai Tsukuba, Ibaraki, Japan; Translational Medical Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan.Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan.Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan.Medical Genome Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan; Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan.Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8551, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31708335

Citation

Mori-Yoshimura, Madoka, et al. "Psychiatric and Neurodevelopmental Aspects of Becker Muscular Dystrophy." Neuromuscular Disorders : NMD, vol. 29, no. 12, 2019, pp. 930-939.
Mori-Yoshimura M, Mizuno Y, Yoshida S, et al. Psychiatric and neurodevelopmental aspects of Becker muscular dystrophy. Neuromuscul Disord. 2019;29(12):930-939.
Mori-Yoshimura, M., Mizuno, Y., Yoshida, S., Ishihara, N., Minami, N., Morimoto, E., ... Takahashi, Y. (2019). Psychiatric and neurodevelopmental aspects of Becker muscular dystrophy. Neuromuscular Disorders : NMD, 29(12), pp. 930-939. doi:10.1016/j.nmd.2019.09.006.
Mori-Yoshimura M, et al. Psychiatric and Neurodevelopmental Aspects of Becker Muscular Dystrophy. Neuromuscul Disord. 2019;29(12):930-939. PubMed PMID: 31708335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychiatric and neurodevelopmental aspects of Becker muscular dystrophy. AU - Mori-Yoshimura,Madoka, AU - Mizuno,Yukio, AU - Yoshida,Sumiko, AU - Ishihara,Naoko, AU - Minami,Narihiro, AU - Morimoto,Emiko, AU - Maruo,Kazushi, AU - Nonaka,Ikuya, AU - Komaki,Hirofumi, AU - Nishino,Ichizo, AU - Sekiguchi,Masayuki, AU - Sato,Noriko, AU - Takeda,Shin'ichi, AU - Takahashi,Yuji, Y1 - 2019/09/18/ PY - 2019/05/22/received PY - 2019/09/04/revised PY - 2019/09/05/accepted PY - 2019/11/12/pubmed PY - 2019/11/12/medline PY - 2019/11/12/entrez KW - Becker muscular dystrophy KW - Brain MRI KW - Bullying KW - Dystrophinopathy KW - Neurodevelopmental disorders KW - Psychiatric diseases SP - 930 EP - 939 JF - Neuromuscular disorders : NMD JO - Neuromuscul. Disord. VL - 29 IS - 12 N2 - Little is known about the relationship between Becker Muscular Dystrophy (BMD) and mental disorders. This study aimed to clarify whether BMD is a risk factor for psychiatric diseases. We asked genetically or immunohistochemically confirmed BMD patients to participate in the study interview. Participants who consented to psychiatric tests underwent further assessments of intellectual, psychological, and neurodevelopmental disorders. In total, 76 (73%) of 105 BMD patients (median age, 37 years) completed the interview. Of these, 6 had developmental disorders (mental retardation, pervasive developmental disorder), 33/76 (43%) experienced bullying in school, 11 exhibited problematic behaviors such as cutting class and violent incidents, and 16 had psychiatric disorders (schizophrenia spectrum, 5; depressive spectrum, 4; stress-related disorders, 3; obsessive-compulsive and related disorders, 2; somatic symptom and related disorders, 2; bipolar and related disorders, 1). Mean IQ was normal, whereas 13/40 (32.5%) of participants were in a depressive state. High trait anxiety was found in 20/40 (50%) of patients, while 15/40 (38.5%) were in an anxious state. Review of MRI data from 14 participants revealed brain atrophy caused solely by BMD and unrelated to any other complication. Our findings suggest that BMD patients are at risk of developing psychiatric disorders. Physical handicap or bullying may influence their mental state, as many of them have high trait anxiety. Parents, teachers, and supporters should be mindful of the daily environment of BMD patients and provide support to help them cope with stress. SN - 1873-2364 UR - https://www.unboundmedicine.com/medline/citation/31708335/Psychiatric_and_neurodevelopmental_aspects_of_Becker_muscular_dystrophy L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-8966(19)31113-7 DB - PRIME DP - Unbound Medicine ER -