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Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews.
Int J Fertil Steril. 2020 Jan; 13(4):257-270.IJ

Abstract

Polycystic ovary syndrome (PCOS) is a common, complex condition that affects up to 18% of reproductiveaged women, causing reproductive, metabolic and psychological dysfunctions. We performed an overview and appraisal of methodological quality of systematic reviews that assessed medical and surgical treatments for reproductive outcomes in women with PCOS. Databases (MEDLINE, EMBASE, CINAHL PLUS and PROSPERO) were searched on the 15th of September 2017. We included any systematic review that assessed the effect of medical or surgical management of PCOS on reproductive, pregnancy and neonatal outcomes. Eligibility assessment, data extraction and quality assessment by the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) tool were performed in duplicate. We identified 53 reviews comprising 44 reviews included in this overview; the majority were moderate to high quality. In unselected women with PCOS, letrozole was associated with a higher live birth rate than clomiphene citrate (CC), while CC was better than metformin or placebo. In women with CC-resistant PCOS, gonadotrophins were associated with a higher live birth rate than CC plus metformin, which was better than laparoscopic ovarian drilling (LOD). LOD was associated with lower multiple pregnancy rates than other medical treatments. In women with PCOS undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), the addition of metformin to gonadotrophins resulted in less ovarian hyperstimulation syndrome (OHSS), and higher pregnancy and live birth rates than gonadotrophins alone. Gonadotrophin releasing hormone (GnRH) antagonist was associated with less OHSS, gonadotrophin units and shorter stimulation length than GnRH agonist. Letrozole appears to be a good first line treatment and gonadotrophins, as a second line treatment, for anovulatory women with PCOS. LOD results in lower multiple pregnancy rates. However, due to the heterogeneous nature of the included populations of women with PCOS, further larger scale trials are needed with more precise assessment of treatments according to heterogeneous variants of PCOS.

Authors+Show Affiliations

Women's Health Hospital, Department of Obstetrics and Gynaecology, Assiut University, Assiut, Egypt.Elevtronic Address:moustafaabdelhafez@yahoo.com. Robinson Research Institute, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia.Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Victoria, Melbourne, Australia. Monash Diabetes and Endocrinology Units, Monash Health, Victoria, Melbourne, Australia.No affiliation info availableInstitute of Sport, Exercise and Active Living, Victoria University, Melbourne, Australia.Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Victoria, Melbourne, Australia.Centre of Reproductive Medicine, St Bartholomew's Hospital, London, United Kingdom.Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom.Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Victoria, Melbourne, Australia. Monash Diabetes and Endocrinology Units, Monash Health, Victoria, Melbourne, Australia.Robinson Research Institute, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia. Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Melbourne, Australia.Robinson Research Institute, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia. Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Victoria, Melbourne, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31710185

Citation

Gadalla, Moustafa A., et al. "Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: an Overview of Systematic Reviews." International Journal of Fertility & Sterility, vol. 13, no. 4, 2020, pp. 257-270.
Gadalla MA, Norman RJ, Tay CT, et al. Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews. Int J Fertil Steril. 2020;13(4):257-270.
Gadalla, M. A., Norman, R. J., Tay, C. T., Hiam, D. S., Melder, A., Pundir, J., Thangaratinam, S., Teede, H. J., Mol, B. W. J., & Moran, L. J. (2020). Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews. International Journal of Fertility & Sterility, 13(4), 257-270. https://doi.org/10.22074/ijfs.2020.5608
Gadalla MA, et al. Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: an Overview of Systematic Reviews. Int J Fertil Steril. 2020;13(4):257-270. PubMed PMID: 31710185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome: An Overview of Systematic Reviews. AU - Gadalla,Moustafa A, AU - Norman,Robert J, AU - Tay,Chau T, AU - Hiam,Danielle S, AU - Melder,Angela, AU - Pundir,Jyotsna, AU - Thangaratinam,Shakila, AU - Teede,Helena J, AU - Mol,Ben W J, AU - Moran,Lisa J, Y1 - 2019/11/11/ PY - 2018/11/01/received PY - 2019/03/10/accepted PY - 2019/11/12/entrez PY - 2019/11/12/pubmed PY - 2019/11/12/medline KW - Infertility KW - Polycystic Ovary Syndrome KW - Review KW - Therapeutics KW - Treatment Outcome SP - 257 EP - 270 JF - International journal of fertility & sterility JO - Int J Fertil Steril VL - 13 IS - 4 N2 - Polycystic ovary syndrome (PCOS) is a common, complex condition that affects up to 18% of reproductiveaged women, causing reproductive, metabolic and psychological dysfunctions. We performed an overview and appraisal of methodological quality of systematic reviews that assessed medical and surgical treatments for reproductive outcomes in women with PCOS. Databases (MEDLINE, EMBASE, CINAHL PLUS and PROSPERO) were searched on the 15th of September 2017. We included any systematic review that assessed the effect of medical or surgical management of PCOS on reproductive, pregnancy and neonatal outcomes. Eligibility assessment, data extraction and quality assessment by the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) tool were performed in duplicate. We identified 53 reviews comprising 44 reviews included in this overview; the majority were moderate to high quality. In unselected women with PCOS, letrozole was associated with a higher live birth rate than clomiphene citrate (CC), while CC was better than metformin or placebo. In women with CC-resistant PCOS, gonadotrophins were associated with a higher live birth rate than CC plus metformin, which was better than laparoscopic ovarian drilling (LOD). LOD was associated with lower multiple pregnancy rates than other medical treatments. In women with PCOS undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), the addition of metformin to gonadotrophins resulted in less ovarian hyperstimulation syndrome (OHSS), and higher pregnancy and live birth rates than gonadotrophins alone. Gonadotrophin releasing hormone (GnRH) antagonist was associated with less OHSS, gonadotrophin units and shorter stimulation length than GnRH agonist. Letrozole appears to be a good first line treatment and gonadotrophins, as a second line treatment, for anovulatory women with PCOS. LOD results in lower multiple pregnancy rates. However, due to the heterogeneous nature of the included populations of women with PCOS, further larger scale trials are needed with more precise assessment of treatments according to heterogeneous variants of PCOS. SN - 2008-076X UR - https://www.unboundmedicine.com/medline/citation/31710185/Medical_and_Surgical_Treatment_of_Reproductive_Outcomes_in_Polycystic_Ovary_Syndrome:_An_Overview_of_Systematic_Reviews L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31710185/ DB - PRIME DP - Unbound Medicine ER -
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