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Increased risk for venous thromboembolism among patients with concurrent depressive, bipolar, and schizophrenic disorders.
Gen Hosp Psychiatry 2019 Nov - Dec; 61:34-40GH

Abstract

OBJECTIVE

The study aim was to investigate the risk of venous thromboembolism (VTE) in patients with concurrent depressive, bipolar, and schizophrenic disorders.

METHODS

A population-based cohort study was conducted in which information regarding psychiatric illnesses and medical comorbidities in 29,467 patients with concurrent depressive, bipolar, and schizophrenic disorders and regarding 117,868 controls were extracted. We compared the incidence of VTE between the study and control cohorts. Cox proportional hazard regression models were used to analyze the risk of VTE after adjusting for potential confounders, including sex, age, and comorbidities.

RESULTS

Compared with the control cohort, the overall study cohort had a 2.995-fold higher adjusted hazard ratio (aHR) for development of deep vein thrombosis (DVT) and a 2.591-fold higher aHR for development of pulmonary embolism (PE). Moreover, patients with depressive, bipolar, and schizophrenic disorders all exhibited higher aHRs for development of both DVT and PE.

CONCLUSION

The relative risks of DVT and PE were higher in patients with concurrent depressive, bipolar, and schizophrenic disorders than those of the general population. Further research is needed to develop effective prevention strategies for different patient populations.

Authors+Show Affiliations

Department of Psychiatry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan; School of Public Health, National Defense Medical Center, Taipei, Taiwan.Department of Psychiatry, Hualien Armed Forces General Hospital, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan.Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan; Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan; School of Public Health, National Defense Medical Center, Taipei, Taiwan. Electronic address: chienwu@mail.ndmctsgh.edu.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31710856

Citation

Lin, Ching-En, et al. "Increased Risk for Venous Thromboembolism Among Patients With Concurrent Depressive, Bipolar, and Schizophrenic Disorders." General Hospital Psychiatry, vol. 61, 2019, pp. 34-40.
Lin CE, Chung CH, Chen LF, et al. Increased risk for venous thromboembolism among patients with concurrent depressive, bipolar, and schizophrenic disorders. Gen Hosp Psychiatry. 2019;61:34-40.
Lin, C. E., Chung, C. H., Chen, L. F., & Chien, W. C. (2019). Increased risk for venous thromboembolism among patients with concurrent depressive, bipolar, and schizophrenic disorders. General Hospital Psychiatry, 61, pp. 34-40. doi:10.1016/j.genhosppsych.2019.10.003.
Lin CE, et al. Increased Risk for Venous Thromboembolism Among Patients With Concurrent Depressive, Bipolar, and Schizophrenic Disorders. Gen Hosp Psychiatry. 2019;61:34-40. PubMed PMID: 31710856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased risk for venous thromboembolism among patients with concurrent depressive, bipolar, and schizophrenic disorders. AU - Lin,Ching-En, AU - Chung,Chi-Hsiang, AU - Chen,Li-Fen, AU - Chien,Wu-Chien, Y1 - 2019/11/08/ PY - 2019/08/29/received PY - 2019/09/27/revised PY - 2019/10/04/accepted PY - 2019/11/12/pubmed PY - 2019/11/12/medline PY - 2019/11/12/entrez KW - Bipolar disorder KW - Deep vein thrombosis KW - Depression KW - Pulmonary embolism KW - Schizophrenia SP - 34 EP - 40 JF - General hospital psychiatry JO - Gen Hosp Psychiatry VL - 61 N2 - OBJECTIVE: The study aim was to investigate the risk of venous thromboembolism (VTE) in patients with concurrent depressive, bipolar, and schizophrenic disorders. METHODS: A population-based cohort study was conducted in which information regarding psychiatric illnesses and medical comorbidities in 29,467 patients with concurrent depressive, bipolar, and schizophrenic disorders and regarding 117,868 controls were extracted. We compared the incidence of VTE between the study and control cohorts. Cox proportional hazard regression models were used to analyze the risk of VTE after adjusting for potential confounders, including sex, age, and comorbidities. RESULTS: Compared with the control cohort, the overall study cohort had a 2.995-fold higher adjusted hazard ratio (aHR) for development of deep vein thrombosis (DVT) and a 2.591-fold higher aHR for development of pulmonary embolism (PE). Moreover, patients with depressive, bipolar, and schizophrenic disorders all exhibited higher aHRs for development of both DVT and PE. CONCLUSION: The relative risks of DVT and PE were higher in patients with concurrent depressive, bipolar, and schizophrenic disorders than those of the general population. Further research is needed to develop effective prevention strategies for different patient populations. SN - 1873-7714 UR - https://www.unboundmedicine.com/medline/citation/31710856/Increased_risk_for_venous_thromboembolism_among_patients_with_concurrent_depressive,_bipolar,_and_schizophrenic_disorders L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-8343(19)30362-7 DB - PRIME DP - Unbound Medicine ER -