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Alcohol intake during pregnancy and timing of puberty in sons and daughters: A nationwide cohort study.
Reprod Toxicol. 2020 01; 91:35-42.RT

Abstract

We explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000-2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012-2018. Information on maternal average alcohol intake in first trimester and binge drinking episodes (intake of ≥5 drinks on the same occasion) in first trimester was self-reported by mothers during pregnancy. Average alcohol intake of 5+ weekly drinks in first trimester was not associated with pubertal timing in sons (with no alcohol intake as the reference). A tendency towards earlier pubertal timing was observed in daughters (-2.0 (95 % confidence interval: -4.2, 0.3) months) when combining the estimates for all pubertal milestones. Binge drinking was not associated with pubertal timing in neither sons nor daughters.

Authors+Show Affiliations

Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000, Aarhus, Denmark. Electronic address: nis.brix@gmail.com.Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000, Aarhus, Denmark. Electronic address: llbl@ph.au.dk.Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000, Aarhus, Denmark. Electronic address: aernst@ph.au.dk.Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43- 45, DK-8200, Aarhus, Denmark; Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), 650 Charles E. Young Drive South, Los Angeles, CA, 90095-1772, USA. Electronic address: jo@ph.au.dk.Perinatal Epidemiology Research Unit, Department of Pediatrics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 103, DK-8200, Aarhus, Denmark. Electronic address: tine.brink.henriksen@clin.au.dk.Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000, Aarhus, Denmark. Electronic address: chrh@ph.au.dk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31711902

Citation

Brix, Nis, et al. "Alcohol Intake During Pregnancy and Timing of Puberty in Sons and Daughters: a Nationwide Cohort Study." Reproductive Toxicology (Elmsford, N.Y.), vol. 91, 2020, pp. 35-42.
Brix N, Lauridsen LLB, Ernst A, et al. Alcohol intake during pregnancy and timing of puberty in sons and daughters: A nationwide cohort study. Reprod Toxicol. 2020;91:35-42.
Brix, N., Lauridsen, L. L. B., Ernst, A., Olsen, J., Henriksen, T. B., & Ramlau-Hansen, C. H. (2020). Alcohol intake during pregnancy and timing of puberty in sons and daughters: A nationwide cohort study. Reproductive Toxicology (Elmsford, N.Y.), 91, 35-42. https://doi.org/10.1016/j.reprotox.2019.11.003
Brix N, et al. Alcohol Intake During Pregnancy and Timing of Puberty in Sons and Daughters: a Nationwide Cohort Study. Reprod Toxicol. 2020;91:35-42. PubMed PMID: 31711902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol intake during pregnancy and timing of puberty in sons and daughters: A nationwide cohort study. AU - Brix,Nis, AU - Lauridsen,Lea L B, AU - Ernst,Andreas, AU - Olsen,Jørn, AU - Henriksen,Tine B, AU - Ramlau-Hansen,Cecilia H, Y1 - 2019/11/08/ PY - 2019/06/28/received PY - 2019/11/06/revised PY - 2019/11/07/accepted PY - 2019/11/13/pubmed PY - 2019/11/13/medline PY - 2019/11/13/entrez KW - Alcohol KW - Maternal exposure KW - Menarche KW - Prenatal exposure delayed effects KW - Puberty SP - 35 EP - 42 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod Toxicol VL - 91 N2 - We explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000-2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012-2018. Information on maternal average alcohol intake in first trimester and binge drinking episodes (intake of ≥5 drinks on the same occasion) in first trimester was self-reported by mothers during pregnancy. Average alcohol intake of 5+ weekly drinks in first trimester was not associated with pubertal timing in sons (with no alcohol intake as the reference). A tendency towards earlier pubertal timing was observed in daughters (-2.0 (95 % confidence interval: -4.2, 0.3) months) when combining the estimates for all pubertal milestones. Binge drinking was not associated with pubertal timing in neither sons nor daughters. SN - 1873-1708 UR - https://www.unboundmedicine.com/medline/citation/31711902/Alcohol_intake_during_pregnancy_and_timing_of_puberty_in_sons_and_daughters:_A_nationwide_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-6238(19)30316-8 DB - PRIME DP - Unbound Medicine ER -