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The effects of verapamil and heparin co-administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats.
Andrologia. 2020 Mar; 52(2):e13479.A

Abstract

In this research, the impacts of combined administration of verapamil and heparin on testicular torsion damage were examined. In this experimental study, 30 sexually mature male Wistar albino rats were divided into five equal groups haphazardly (n = 6): Group 1 was the sham group. In group 2, a 2-hr testicular torsion was induced, and thereafter, detorsion was done. Rats in group 3 and group 4 experienced an identical surgical procedure like group 2, but verapamil and heparin were administered in 0.3 mg/kg and 800 IU/kg doses respectively, and in group 5, a combination of verapamil and heparin were administered. Intraperitoneal drug injection in all treatment groups was done 30 min before testicular detorsion. Testicular torsion significantly changed sperm parameters, oxidative stress biomarkers and Cosentino's histological score compared to the sham group (p < .05). All treatment groups reduced testicular damage by decreasing oxidative stress and improving sperm parameters, but heparin and co-administration of verapamil and heparin were significantly better than verapamil injection alone. However, heparin injected group was more effective than other treatment groups (p < .05). Overall, an anticoagulant like heparin is more effective than a calcium channel blocker such as verapamil, and it is more likely to reduce testicular torsion injuries.

Authors+Show Affiliations

Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.Razi Vaccine and Serum Research Institute, Agriculture Research, Education and Extension Organization (AREEO), Karaj, Iran.Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31713254

Citation

Davoodi, Farshid, et al. "The Effects of Verapamil and Heparin Co-administration On Sperm Parameters and Oxidative Stress in Prevention of Testicular Torsion/detorsion Damage in Rats." Andrologia, vol. 52, no. 2, 2020, pp. e13479.
Davoodi F, Raisi A, Rajabzadeh A, et al. The effects of verapamil and heparin co-administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats. Andrologia. 2020;52(2):e13479.
Davoodi, F., Raisi, A., Rajabzadeh, A., Hablolvarid, M. H., & Zakian, A. (2020). The effects of verapamil and heparin co-administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats. Andrologia, 52(2), e13479. https://doi.org/10.1111/and.13479
Davoodi F, et al. The Effects of Verapamil and Heparin Co-administration On Sperm Parameters and Oxidative Stress in Prevention of Testicular Torsion/detorsion Damage in Rats. Andrologia. 2020;52(2):e13479. PubMed PMID: 31713254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of verapamil and heparin co-administration on sperm parameters and oxidative stress in prevention of testicular torsion/detorsion damage in rats. AU - Davoodi,Farshid, AU - Raisi,Abbas, AU - Rajabzadeh,Asghar, AU - Hablolvarid,Mohammad Hassan, AU - Zakian,Amir, Y1 - 2019/11/11/ PY - 2019/09/09/received PY - 2019/09/24/revised PY - 2019/10/14/accepted PY - 2019/11/13/pubmed PY - 2020/11/20/medline PY - 2019/11/13/entrez KW - heparin KW - oxidative stress KW - sperm parameters KW - torsion/detorsion KW - verapamil SP - e13479 EP - e13479 JF - Andrologia JO - Andrologia VL - 52 IS - 2 N2 - In this research, the impacts of combined administration of verapamil and heparin on testicular torsion damage were examined. In this experimental study, 30 sexually mature male Wistar albino rats were divided into five equal groups haphazardly (n = 6): Group 1 was the sham group. In group 2, a 2-hr testicular torsion was induced, and thereafter, detorsion was done. Rats in group 3 and group 4 experienced an identical surgical procedure like group 2, but verapamil and heparin were administered in 0.3 mg/kg and 800 IU/kg doses respectively, and in group 5, a combination of verapamil and heparin were administered. Intraperitoneal drug injection in all treatment groups was done 30 min before testicular detorsion. Testicular torsion significantly changed sperm parameters, oxidative stress biomarkers and Cosentino's histological score compared to the sham group (p < .05). All treatment groups reduced testicular damage by decreasing oxidative stress and improving sperm parameters, but heparin and co-administration of verapamil and heparin were significantly better than verapamil injection alone. However, heparin injected group was more effective than other treatment groups (p < .05). Overall, an anticoagulant like heparin is more effective than a calcium channel blocker such as verapamil, and it is more likely to reduce testicular torsion injuries. SN - 1439-0272 UR - https://www.unboundmedicine.com/medline/citation/31713254/The_effects_of_verapamil_and_heparin_co_administration_on_sperm_parameters_and_oxidative_stress_in_prevention_of_testicular_torsion/detorsion_damage_in_rats_ L2 - https://doi.org/10.1111/and.13479 DB - PRIME DP - Unbound Medicine ER -