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Closed loop automated oxygen control in neonates-A review.

Abstract

AIM

Neonates frequently require supplementary oxygen but may develop complications if the oxygen saturation is outside the target range. This review aimed to determine whether the algorithms used in closed loop automated oxygen control systems influenced their efficacy and whether use of the systems reduced relevant, long-term neonatal complications.

METHODS

A literature search was conducted using PubMed and Google Scholar. The search terms were 'closed loop' or 'automat*', 'oxygen' and 'neonat*'.

RESULTS

Eighteen studies were identified: sixteen comparison clinical studies, an observational study and an animal study. Overall, closed loop automated oxygen control was associated with an increased percentage of time spent within the target oxygen saturation range and there were fewer manual adjustments to the inspired oxygen concentration when compared with manual oxygen control. The systems were effective in infants on non-invasive respiratory support or mechanically ventilated, but no study included term-born infants. No long-term data were available to determine if complications of oxygen toxicity were reduced.

CONCLUSION

Closed loop automated oxygen control has been shown in short term trials including preterm and low birth weight infants to improve target saturation achievement. Whether long-term outcomes will be improved with their use requires investigation.

Authors+Show Affiliations

Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. Neonatal Intensive Care Centre, King's College Hospital, London, UK.Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. The Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK. National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust, King's College London, London, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31715041

Citation

Sturrock, Sarah, et al. "Closed Loop Automated Oxygen Control in neonates-A Review." Acta Paediatrica (Oslo, Norway : 1992), 2019.
Sturrock S, Williams E, Dassios T, et al. Closed loop automated oxygen control in neonates-A review. Acta Paediatr. 2019.
Sturrock, S., Williams, E., Dassios, T., & Greenough, A. (2019). Closed loop automated oxygen control in neonates-A review. Acta Paediatrica (Oslo, Norway : 1992), doi:10.1111/apa.15089.
Sturrock S, et al. Closed Loop Automated Oxygen Control in neonates-A Review. Acta Paediatr. 2019 Nov 12; PubMed PMID: 31715041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Closed loop automated oxygen control in neonates-A review. AU - Sturrock,Sarah, AU - Williams,Emma, AU - Dassios,Theodore, AU - Greenough,Anne, Y1 - 2019/11/12/ PY - 2019/09/27/received PY - 2019/11/07/revised PY - 2019/11/11/accepted PY - 2019/11/13/pubmed PY - 2019/11/13/medline PY - 2019/11/13/entrez KW - bronchopulmonary dysplasia KW - closed loop automated oxygen control KW - neonate KW - retinopathy of prematurity JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. N2 - AIM: Neonates frequently require supplementary oxygen but may develop complications if the oxygen saturation is outside the target range. This review aimed to determine whether the algorithms used in closed loop automated oxygen control systems influenced their efficacy and whether use of the systems reduced relevant, long-term neonatal complications. METHODS: A literature search was conducted using PubMed and Google Scholar. The search terms were 'closed loop' or 'automat*', 'oxygen' and 'neonat*'. RESULTS: Eighteen studies were identified: sixteen comparison clinical studies, an observational study and an animal study. Overall, closed loop automated oxygen control was associated with an increased percentage of time spent within the target oxygen saturation range and there were fewer manual adjustments to the inspired oxygen concentration when compared with manual oxygen control. The systems were effective in infants on non-invasive respiratory support or mechanically ventilated, but no study included term-born infants. No long-term data were available to determine if complications of oxygen toxicity were reduced. CONCLUSION: Closed loop automated oxygen control has been shown in short term trials including preterm and low birth weight infants to improve target saturation achievement. Whether long-term outcomes will be improved with their use requires investigation. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/31715041/Closed_loop_automated_oxygen_control_in_neonates_-_a_review L2 - https://doi.org/10.1111/apa.15089 DB - PRIME DP - Unbound Medicine ER -