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DEFINITION OF VITAMIN D DEFICIENCY IN SCHOOLCHILDREN: SYSTEMATIC REVIEW WITH META-ANALYSIS.
Arq Gastroenterol 2019 Oct-Dec; 56(4):425-430AG

Abstract

BACKGROUND

Vitamin D deficiency is being recognized as a pandemic due to the volume of people affected by the deficiency and the number of illnesses generated or stimulated by the deficiency. There is a lack of consensus in the literature on what is considered vitamin D deficiency [25(OH)D].

OBJECTIVE

This review brings together the most common levels of 25(OH)D found in healthy schoolchildren and what is considered deficient.

METHODS

This systematic review was based on the literature accessed from the electronic databases: MEDLINE, EMBASE, LILACS, SCOPUS and WEB OF SCIENCE. The following descriptors were used in English, Portuguese and Spanish: "Vitamin D"; "Vitamin D deficiency"; "Nutritional Supplements" as well as all their synonyms. The meta-analysis was performed considering the random model. Inclusion criteria: healthy children aged 6 to 12 years, studies that had vitamin D levels, defined vitamin D deficiency.

RESULTS

Of the 191 potentially eligible articles, only six articles were included, with 2618 students in total. The mean value of 25(OH)D was estimated at 18.11 ng/mL with 95% confidence interval. Among the articles found, three were considered deficiency levels below 20 ng/mL, one considered below 18 ng/mL, another below 15 ng/mL, and the latter below 11 ng/ mL. The prevalence of vitamin D deficiency among the articles was 48.6%, 7%, 98%, 64.63%, 19.5%, 28.4%, according to each classification used by the same.

CONCLUSION

The most common definition in the literature of 25(OH)D deficiency in schoolchildren was at levels below 20 ng/mL. No side effects have been reported in studies that used fortification and/or vitamin D supplementation. Daily supplementation is more effective than seasonal supplementation. However, more studies are needed to define what can be considered as optimal levels of 25(OH)D in children.

Authors+Show Affiliations

Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil.Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil.Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil.Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil.Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31721968

Citation

Linden, Marcela Almeida, et al. "DEFINITION of VITAMIN D DEFICIENCY in SCHOOLCHILDREN: SYSTEMATIC REVIEW WITH META-ANALYSIS." Arquivos De Gastroenterologia, vol. 56, no. 4, 2019, pp. 425-430.
Linden MA, Freitas RGBON, Hessel G, et al. DEFINITION OF VITAMIN D DEFICIENCY IN SCHOOLCHILDREN: SYSTEMATIC REVIEW WITH META-ANALYSIS. Arq Gastroenterol. 2019;56(4):425-430.
Linden, M. A., Freitas, R. G. B. O. N., Hessel, G., Marmo, D. B., & Bellomo-Brandão, M. Â. (2019). DEFINITION OF VITAMIN D DEFICIENCY IN SCHOOLCHILDREN: SYSTEMATIC REVIEW WITH META-ANALYSIS. Arquivos De Gastroenterologia, 56(4), pp. 425-430. doi:10.1590/S0004-2803.201900000-64.
Linden MA, et al. DEFINITION of VITAMIN D DEFICIENCY in SCHOOLCHILDREN: SYSTEMATIC REVIEW WITH META-ANALYSIS. Arq Gastroenterol. 2019;56(4):425-430. PubMed PMID: 31721968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DEFINITION OF VITAMIN D DEFICIENCY IN SCHOOLCHILDREN: SYSTEMATIC REVIEW WITH META-ANALYSIS. AU - Linden,Marcela Almeida, AU - Freitas,Renata Germano Borges de Oliveira Nascimento, AU - Hessel,Gabriel, AU - Marmo,Denise Barbieri, AU - Bellomo-Brandão,Maria Ângela, PY - 2019/04/12/received PY - 2019/09/12/accepted PY - 2019/11/14/pubmed PY - 2019/11/14/medline PY - 2019/11/14/entrez SP - 425 EP - 430 JF - Arquivos de gastroenterologia JO - Arq Gastroenterol VL - 56 IS - 4 N2 - BACKGROUND: Vitamin D deficiency is being recognized as a pandemic due to the volume of people affected by the deficiency and the number of illnesses generated or stimulated by the deficiency. There is a lack of consensus in the literature on what is considered vitamin D deficiency [25(OH)D]. OBJECTIVE: This review brings together the most common levels of 25(OH)D found in healthy schoolchildren and what is considered deficient. METHODS: This systematic review was based on the literature accessed from the electronic databases: MEDLINE, EMBASE, LILACS, SCOPUS and WEB OF SCIENCE. The following descriptors were used in English, Portuguese and Spanish: "Vitamin D"; "Vitamin D deficiency"; "Nutritional Supplements" as well as all their synonyms. The meta-analysis was performed considering the random model. Inclusion criteria: healthy children aged 6 to 12 years, studies that had vitamin D levels, defined vitamin D deficiency. RESULTS: Of the 191 potentially eligible articles, only six articles were included, with 2618 students in total. The mean value of 25(OH)D was estimated at 18.11 ng/mL with 95% confidence interval. Among the articles found, three were considered deficiency levels below 20 ng/mL, one considered below 18 ng/mL, another below 15 ng/mL, and the latter below 11 ng/ mL. The prevalence of vitamin D deficiency among the articles was 48.6%, 7%, 98%, 64.63%, 19.5%, 28.4%, according to each classification used by the same. CONCLUSION: The most common definition in the literature of 25(OH)D deficiency in schoolchildren was at levels below 20 ng/mL. No side effects have been reported in studies that used fortification and/or vitamin D supplementation. Daily supplementation is more effective than seasonal supplementation. However, more studies are needed to define what can be considered as optimal levels of 25(OH)D in children. SN - 1678-4219 UR - https://www.unboundmedicine.com/medline/citation/31721968/DEFINITION_OF_VITAMIN_D_DEFICIENCY_IN_SCHOOLCHILDREN:_SYSTEMATIC_REVIEW_WITH_META_ANALYSIS_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032019005004102&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -